Ronald D Seidel

US Patent:

20190153065, May 23, 2019

Filed:

May 17, 2017

Appl. No.:

16/098983

Inventors:

- Bronx NY, US
Steven C. Almo - Pelham NY, US
Ronald D. Seidel III - Larchmont NY, US

Assignee:

ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. - Bronx NY

International Classification:

C07K 14/705
C07K 14/74
A61K 9/00

Abstract:

The present disclosure provides variant PD-L1 immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T-cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell; the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure.