Robert John Ternansky

US Patent:

6376492, Apr 23, 2002

Filed:

May 9, 2000

Appl. No.:

09/567857

Inventors:

Peter Thomas Lind - Huddinge, SE
Rolf Noréen - Huddinge, SE
John Michael Morin - Brownsburg IN
Robert John Ternansky - Carlsbad CA

Assignee:

Medivir AB - Huddinge

International Classification:

A61K 31252

US Classification:

514252, 514255, 514256, 544238, 544241, 544297, 544322, 544333, 544359, 544392, 544403

Abstract:

The present invention is directed to compounds, compositions and methods of inhibiting and treating HIV and related viruses, and methods for cocrystallizing reverse transcriptase in vitro, inhibition of the replication of HIV and related viruses thereof.

US Patent:

6515173, Feb 4, 2003

Filed:

Jan 13, 2000

Appl. No.:

09/482813

Inventors:

Robert J. Ternansky - Carlsbad CA
Patricia L. Gladstone - San Diego CA
Kevin J. Tomaselli - San Diego CA

Assignee:

Idun Pharmaceuticals, Inc. - San Diego CA

International Classification:

C07K 506

US Classification:

562553, 514 19, 562563, 562576

Abstract:

This invention s directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, R, R , p and q are as defined herein. The invention s all directed to pharmaceutical compositions containing one or more of thee compound, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that to undergo a transplantation procedure.

US Patent:

6525024, Feb 25, 2003

Filed:

Apr 17, 2001

Appl. No.:

09/837614

Inventors:

Robert J. Ternansky - Carlsbad CA
Patricia L. Gladstone - San Diego CA
Kevin J. Tomaselli - San Diego CA

Assignee:

Idun Pharmaceuticals, Inc. - San Diego CA

International Classification:

C07K 506

US Classification:

514 19, 530331, 514 18, 562561, 562563

Abstract:

This invention is directed to novel sulfonimide (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, X, R, R , R , n, q, and r are as defined herein. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

US Patent:

6544951, Apr 8, 2003

Filed:

Dec 19, 2000

Appl. No.:

09/745204

Inventors:

Donald S. Karanewsky - Escondido CA
Robert J. Ternansky - Carlsbad CA

Assignee:

Idun Pharmaceuticals, Inc. - San Diego CA

International Classification:

C07K 506

US Classification:

514 19, 548517, 548527, 544360, 5462784

Abstract:

This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

US Patent:

6790989, Sep 14, 2004

Filed:

Jul 18, 2001

Appl. No.:

09/908969

Inventors:

Robert J. Ternansky - San Diego CA
Patricia L. Gladstone - San Diego CA
Kevin J. Tomaselli - San Diego CA
Bin Chao - San Diego CA
Steven D. Linton - San Diego CA

Assignee:

Idun Pharmaceuticals, Inc. - San Diego CA

International Classification:

C07K 506

US Classification:

562553, 514 19, 562563, 562576

Abstract:

This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, R, R , R p and q are as defined herein. The invention is also directed to pharmaceutical compositions containing one or more of these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmnune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

US Patent:

6969703, Nov 29, 2005

Filed:

Dec 17, 2002

Appl. No.:

10/322361

Inventors:

Robert J. Ternansky - San Diego CA, US
Patricia L. Gladstone - San Diego CA, US
Kevin J. Tomaselli - San Diego CA, US

Assignee:

Idun Pharmaceuticals, Inc. - San Diego CA

International Classification:

C07K005/06

US Classification:

514 19, 530331, 514 18, 562561, 562563

Abstract:

This invention is directed to novel sulfonimide (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, X, R, R, R, n, q, and r are as defined herein. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

US Patent:

7053056, May 30, 2006

Filed:

Jan 16, 2001

Appl. No.:

09/765105

Inventors:

Donald S. Karanewsky - Escondido CA, US
Robert J. Ternansky - San Diego CA, US
Steven D. Linton - San Diego CA, US
Thang Dinh - Garden Grove CA, US

Assignee:

Idun Pharmaceuticals, Inc. - San Diego CA

International Classification:

C07K 5/06

US Classification:

514 19, 5483215, 548492, 548517, 548527, 544360, 5462784, 530331

Abstract:

This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

US Patent:

7183260, Feb 27, 2007

Filed:

Aug 25, 2004

Appl. No.:

10/926800

Inventors:

Donald S Karanewsky - Escondido CA, US
Robert J Ternansky - San Diego CA, US
Steven D Linton - San Diego CA, US
Thang Dinh - Garden Grove CA, US

Assignee:

Idun Pharmaceuticals, Inc. - San Diego CA

International Classification:

C07K 5/06

US Classification:

514 19, 548517, 548527, 544360, 5462784

Abstract:

This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.