Robert Michael Rzasa

US Patent:

7119111, Oct 10, 2006

Filed:

May 27, 2003

Appl. No.:

10/446440

Inventors:

Qi Huang - Moorpark CA, US
Matthew Kaller - Ventura CA, US
Thomas Nguyen - Thousand Oaks CA, US
Mark H. Norman - Thousand Oaks CA, US
Robert Rzasa - Ventura CA, US
Hui-Ling Wang - Thousand Oaks CA, US
Wenge Zhong - Thousand Oaks CA, US

Assignee:

Amgen, Inc. - Thousand Oaks CA

International Classification:

C07D 277/60
C07D 487/00
A01N 43/78

US Classification:

514365, 548146, 548182, 548190, 544224, 544242, 544245, 544253

Abstract:

Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

7144888, Dec 5, 2006

Filed:

Aug 8, 2003

Appl. No.:

10/638009

Inventors:

Elizabeth M. Doherty - Newbury Park CA, US
Jiawang Zhu - Simi Valley CA, US
Markian Stec - Fillmore CA, US
Mark H. Norman - Thousand Oaks CA, US
Hui-Ling Wang - Thousand Oaks CA, US
Christopher H. Fotsch - Thousand Oaks CA, US
Ning Chen - Thousand Oaks CA, US
Partha P. Chakrabarti - Simi Valley CA, US
Celia Dominguez - Thousand Oaks CA, US
James Richard Falsey - Westlake Village CA, US
Christopher Hulme - Simi Valley CA, US
Jodie Katon - Ventura CA, US
Thomas Nixey - Newbury Park CA, US
Vassil I. Ognyanov - Thousand Oaks CA, US
Liping H. Pettus - Thousand Oaks CA, US
Robert Michael Rzasa - Ventura CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 239/34
C07D 239/38
C07D 401/12
C07D 403/12
C07D 405/12
C07D 409/12
C07D 417/12
A61K 31/505
A61K 31/506
A61K 31/4427
A61P 19/02
A61P 25/06

US Classification:

514269, 544319, 544315, 544323

Abstract:

Compounds having the general structure.

US Patent:

7148221, Dec 12, 2006

Filed:

Aug 1, 2005

Appl. No.:

11/195134

Inventors:

Elizabeth M. Doherty - Newbury Park CA, US
Jiawang Zhu - Simi Valley CA, US
Markian Stec - Fillmore CA, US
Mark H. Norman - Thousand Oaks CA, US
Hui-Ling Wang - Thousand Oaks CA, US
Christopher H. Fotsch - Thousand Oaks CA, US
Ning Chen - Thousand Oaks CA, US
Partha P. Chakrabarti - Simi Valley CA, US
Celia Dominguez - Thousand Oaks CA, US
James Richard Falsey - Westlake Village CA, US
Christopher Hulme - Simi Valley CA, US
Jodie Katon - Ventura CA, US
Thomas Nixey - Newbury Park CA, US
Vassil I. Ognyanov - Thousand Oaks CA, US
Liping H. Pettus - Thousand Oaks CA, US
Robert Michael Rzasa - Ventura CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 237/14
C07D 237/18
C07D 223/16
C07D 223/18
A61K 31/501
A61P 25/06

US Classification:

514247, 51425201, 514183, 51421703, 51422202, 5142268, 5142278, 5142288, 5142315, 514214, 514242, 514245, 544238, 544239, 544179, 544180, 540484, 540596

Abstract:

Compounds having the general structure.

US Patent:

7314933, Jan 1, 2008

Filed:

Oct 21, 2005

Appl. No.:

11/256427

Inventors:

Mark H. Norman - Thousand Oaks CA, US
Vassil I. Ognyanov - Thousand Oaks CA, US
Robert M. Rzasa - Ventura CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 213/44
C07D 213/643
C07D 237/10
C07D 237/14
C07D 239/32
C07D 401/12
C07D 403/12
A61K 31/4427
A61K 31/501
A61K 31/506
A61K 25/06
A61K 29/00

US Classification:

544239, 544319, 5462681, 51425201, 514269, 514345

Abstract:

Substituted nitrogen-containing heterocycles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

US Patent:

7332511, Feb 19, 2008

Filed:

Aug 1, 2005

Appl. No.:

11/195159

Inventors:

Elizabeth M. Doherty - Newbury Park CA, US
Jiawang Zhu - Simi Valley CA, US
Markian Stec - Fillmore CA, US
Mark H. Norman - Thousand Oaks CA, US
Hui-Ling Wang - Thousand Oaks CA, US
Christopher H. Fotsch - Thousand Oaks CA, US
Ning Chen - Thousand Oaks CA, US
Partha P. Chakrabarti - Simi Valley CA, US
Celia Dominguez - Thousand Oaks CA, US
James Richard Falsey - Westlake Village CA, US
Christopher Hulme - Simi Valley CA, US
Jodie Katon - Ventura CA, US
Thomas Nixey - Newbury Park CA, US
Vassil I. Ognyanov - Thousand Oaks CA, US
Liping H. Pettus - Thousand Oaks CA, US
Robert Michael Rzasa - Ventura CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 213/30
C07D 213/32
C07D 401/12
C07D 401/14
C07D 403/12
C07D 403/14
A61K 31/4427
A61P 19/02
A61P 35/00

US Classification:

514345, 5462681, 544 8, 544 53, 544 56, 544 59, 544 63, 544 67, 544 88, 544106, 544238, 544242, 544338, 540450, 540484

Abstract:

Compounds having the general structure.

US Patent:

7700593, Apr 20, 2010

Filed:

Oct 5, 2007

Appl. No.:

11/973076

Inventors:

Dawei Zhang - Thousand Oaks CA, US
Andrew Tasker - Simi Valley CA, US
Kelvin K. C. Sham - Thousand Oaks CA, US
Partha Pratim Chakrabarti - Nagpur, IN
James Richard Falsey - Moorpark CA, US
Bradley J. Herberich - Newbury Park CA, US
Liping H. Pettus - Thousand Oaks CA, US
Robert M. Rzasa - Ventura CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/5377
C07D 221/02
A61K 31/496
A61P 29/00
C07D 295/00
A61K 31/437

US Classification:

5142332, 514303, 514300, 51425304, 546119, 546121, 544127, 544362

Abstract:

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I.

US Patent:

7705018, Apr 27, 2010

Filed:

Mar 24, 2008

Appl. No.:

12/079322

Inventors:

Yi Chen - San Mateo CA, US
Timothy D. Cushing - Pacifica CA, US
Xiaolin Hao - Foster City CA, US
Xiao He - Foster City CA, US
Andreas Reichelt - Moorpark CA, US
Robert M. Rzasa - Ventura CA, US
Jennifer Seganish - Garwood NJ, US
Youngsook Shin - Emeryville CA, US
Dawei Zhang - Thousand Oaks CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/47

US Classification:

514314, 544333, 546167

Abstract:

Substituted bicyclic heteroaryls having the general formula.

US Patent:

7745449, Jun 29, 2010

Filed:

Apr 23, 2007

Appl. No.:

11/789189

Inventors:

James R. Falsey - Moorpark CA, US
Robert M. Rzasa - Ventura CA, US
Seifu Tadesse - Simi Valley CA, US
Andrew Tasker - Simi Valley CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 495/04
C07D 413/12
A61K 31/519
A61K 31/5355
A61P 29/00
A61P 23/00
C07D 413/04
C07D 513/04
A61K 31/5025

US Classification:

5142601, 5142342, 514248, 544278, 544117, 5442342, 544235

Abstract:

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I.