Robert Kenneth Orr

US Patent:

20090005762, Jan 1, 2009

Filed:

Jun 26, 2007

Appl. No.:

11/768876

Inventors:

Vasu Nishtala - Snellville GA, US
Michael O'Grady - Monroe GA, US
Robert Orr - Covington GA, US
Robert Young - Loganville GA, US

International Classification:

A61M 27/00

US Classification:

604541

Abstract:

A bioabsorbable drain tube for the evacuation of fluids and gases from a body cavity or wound to promote healing, such as after chest surgery. The bioabsorbable drain tube includes a first elongated section molded from a bioabsorbable polymer, the first elongated section having a first end, a second end and a plurality of drain openings; and a second elongated section, the second elongated section having a first end and a second end, the first end of the second elongated section in fluid communication with the second end of the first elongated section. A method of draining fluid from a surgical site or wound of a patient is also provided.

US Patent:

20110124867, May 26, 2011

Filed:

Dec 16, 2008

Appl. No.:

12/809101

Inventors:

Frank Xing Chen - Plainsboro NJ, US
Timothy D. Cutarelli - Clinton NJ, US
Xiayong Fu - Edison NJ, US
Xian Liang - Monmouth Junction NJ, US
Timothy L. McAllister - , US
Robert K. Orr - Cranford NJ, US
Jianguo Yin - Plainsboro NJ, US
Kelvin H. Yong - Lyndhurst NJ, US
Man Zhu - Clark NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D 413/14
C07D 401/14
C07D 403/04
C07D 241/04
C07D 211/44

US Classification:

544357, 544389, 546220

Abstract:

The present invention relates to novel processes for the preparation of the compound of the Formula A45:or a physiologically acceptable salt, solvate or prodrug thereof, which has utility, for example, as a pharmaceutically active compound with CXCR3 antagonist activity, and to novel intermediates useful in the synthesis thereof.

US Patent:

20140031549, Jan 30, 2014

Filed:

Oct 1, 2013

Appl. No.:

14/043210

Inventors:

Gerald Werne - Ketsch, DE
Xiaoyong Fu - Edison NJ, US
Robert K. Orr - Cranford NJ, US
Frank Xing Chen - Plainsboro NJ, US
Jian Cui - Edison NJ, US
Victoria M. Sprague - Bridgewater NJ, US
Fucheng Zhang - Edison NJ, US
Ji Xie - Edison NJ, US
Liansheng Zeng - Union NJ, US
Louis Peter Castellanos - Union City NJ, US
Yuyin Chen - Garwood NJ, US
Marc Poirier - Stewartsville NJ, US
Ingrid Mergelsberg - Mahwah NJ, US

Assignee:

OPKO Health, Inc. - Miami FL

International Classification:

C07D 471/10
C07D 207/267
C07C 217/48
C07D 498/04

US Classification:

546 16, 548217, 548530, 564346, 548550

Abstract:

This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.

US Patent:

20180022747, Jan 25, 2018

Filed:

Feb 12, 2016

Appl. No.:

15/550862

Inventors:

Dongfang MENG - Rahway NJ, US
Hong LI - Rahway NJ, US
Meng YANG - Rahway NJ, US
Manuel de Lera RUIZ - West Point PA, US
Sunita V. DEWNANI - Secaucus NJ, US
Tianying JIAN - Rahway NJ, US
Ting ZHANG - Rahway NJ, US
Louis-Charles CAMPEAU - Rahway NJ, US
Bart HARPER - Rahway NJ, US
Harold B. WOOD - Rahway NJ, US
Jiayi XU - Rahway NJ, US
Richard BERGER - West Point PA, US
Jane Yang WU - Rahway NJ, US
Robert K. ORR - Rahway NJ, US
Shawn P. WALSH - Kenilworth NJ, US
- Rahway NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 471/04
C07D 403/12
C07D 498/04
C07D 417/14
C07D 513/04
C07D 471/14
C07D 413/14

Abstract:

The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.

US Patent:

20160145256, May 26, 2016

Filed:

Feb 1, 2016

Appl. No.:

15/012422

Inventors:

- Miami FL, US
Gerald Werne - Ketsch, DE
Xiaoyong Fu - Edison NJ, US
Robert K. Orr - Cranford NJ, US
Frank Xing Chen - Plainsboro NJ, US
Jian Cui - Edison NJ, US
Victoria M. Sprague - Bridgewater NJ, US
Fucheng Zhang - Edison NJ, US
Ji Xie - Edison NJ, US
Liansheng Zeng - Union NJ, US
Louis Peter Castellanos - Union City NJ, US
Yuyin Chen - Garwood NJ, US
Marc Poirier - Stewartsville NJ, US
Ingrid Mergelsberg - Mahwah NJ, US

International Classification:

C07D 471/10
C07D 207/267
C07C 217/46
C07D 498/04
C07D 207/28

Abstract:

This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.

Author:

Robert J. Orr

ISBN #:

0335211704

Author:

Robert J. Orr

ISBN #:

0335211712

Author:

Robert Thomas Orr

ISBN #:

0025939602

Author:

Robert Thomas Orr

ISBN #:

0030579597

Author:

Robert Thomas Orr

ISBN #:

0721670172

Author:

Robert Thomas Orr

ISBN #:

0721670180

Author:

Robert Thomas Orr

ISBN #:

0883655578

Author:

Robert C. Orr

ISBN #:

0521581850