Robert C Mckay

US Patent:

6448079, Sep 10, 2002

Filed:

Aug 15, 2000

Appl. No.:

09/640101

Inventors:

Brett P. Monia - La Costa CA
William A. Gaarde - Carlsbad CA
Pamela Nero - San Diego CA
Robert McKay - San Diego CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07H 2104

US Classification:

435375, 435 6, 435325, 435455, 536 231, 536 243, 536 2431, 536 2433, 536 245

Abstract:

Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for the treatment and diagnosis of diseases or conditions associated with aberrant expression of one or more p38 MAPKs are also provided.

US Patent:

6455307, Sep 24, 2002

Filed:

Feb 8, 2001

Appl. No.:

09/780173

Inventors:

Robert McKay - San Diego CA
Susan M. Freier - San Diego CA
Jacqueline Wyatt - Encinitas CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C12Q 168

US Classification:

435375, 435 6, 435 911, 435325, 435366, 536 231, 536 2431, 536 2433, 536 245

Abstract:

Antisense compounds, compositions and methods are provided for modulating the expression of Casein kinase 2-alpha prime. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Casein kinase 2-alpha prime. Methods of using these compounds for modulation of Casein kinase 2-alpha prime expression and for treatment of diseases associated with expression of Casein kinase 2-alpha prime are provided.

US Patent:

6602857, Aug 5, 2003

Filed:

Jul 31, 2000

Appl. No.:

09/629644

Inventors:

Lex M. Cowsert - Carlsbad CA 92008
Jacqueline Wyatt - Encinitas CA 92024
Brett P. Monia - La Costa CA 96056
Madeline M. Butler - Rancho Santa Fe CA 92091
Robert McKay - San Diego CA 92107

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

A61K 3828

US Classification:

514 44, 435 6, 435 911, 435375, 435455, 536 231, 536 245, 536 253

Abstract:

Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.

US Patent:

6809193, Oct 26, 2004

Filed:

Jan 31, 2001

Appl. No.:

09/774809

Inventors:

Robert McKay - San Diego CA
Nicholas M. Dean - Olivenhain CA
Brett P. Monia - LaCosta CA
Pamela Nero - San Diego CA
William A. Gaarde - Carlsbad CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C12N 1585

US Classification:

536 245, 435 911, 435325, 435375, 435 6, 435366, 536 231, 536 243, 536 2433, 514 44

Abstract:

Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase (JNK protein) are provided. Oligonucleotide are herein provided which are specifically hybridizable with nucleic acids encoding JNK1, JNK2 and JNK3, as well as other JNK proteins and specific isoforms thereof. Methods of treating animals suffering from diseases or disorders amenable to therapeutic intervention by modulating the expression of one or more JNK proteins with such oligonucleotide are also provided. Methods for the treatment and diagnosis of diseases or disorders associated with aberrant expression of one or more JNK proteins are also provided. Methods for inducing apoptosis and for treating diseases or conditions associated with a reduction in apoptosis are also provided.

US Patent:

7399853, Jul 15, 2008

Filed:

Apr 27, 2004

Appl. No.:

10/832777

Inventors:

Susan M. Freier - San Diego CA, US
Kenneth W. Dobie - Del Mar CA, US
Sanjay Bhanot - Carlsbad CA, US
Robert McKay - Poway CA, US

Assignee:

ISIS Pharmaceuticals - Carlsbad CA

International Classification:

C07H 21/04
C12Q 1/68
C12N 15/85

US Classification:

536 245, 435 6, 435325

Abstract:

Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.

US Patent:

7807649, Oct 5, 2010

Filed:

Apr 23, 2007

Appl. No.:

11/739017

Inventors:

Kenneth W. Dobie - Del Mar CA, US
Sanjay Bhanot - Carlsbad CA, US
Richard A. Lindberg - Thousand Oaks CA, US
John R. Shutter - Moorpark CA, US
Robert McKay - Poway CA, US
Sanjay K. Pandey - Encinitas CA, US

Assignee:

Isis Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

A61K 48/00

US Classification:

514 44, 536 245, 536 2431, 536 241

Abstract:

Antisense compounds, compositions and methods are provided for modulating the expression of forkhead box O1A. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding forkhead box O1A. Methods of using these compounds for modulation of forkhead box O1A expression and for treatment of diseases associated with expression of forkhead box O1A are provided, in particular, for methods of treating diabetes.

US Patent:

7884086, Feb 8, 2011

Filed:

Sep 7, 2005

Appl. No.:

11/221001

Inventors:

C. Frank Bennett - Carlsbad CA, US
Robert McKay - Poway CA, US
Brett P. Monia - Encinitas CA, US
Brenda F. Baker - Carlsbad CA, US
Namir Sioufi - Beirut, LB

Assignee:

Isis Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

A61K 31/70
C07H 21/04

US Classification:

514 44, 536 231, 536 245

Abstract:

The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits.

US Patent:

7897583, Mar 1, 2011

Filed:

May 24, 2006

Appl. No.:

11/915309

Inventors:

Robert McKay - Poway CA, US
Ravi Jain - Carlsbad CA, US
Kenneth W. Dobie - Del Mar CA, US
Sanjay K. Pandey - Encinitas CA, US
Sanjay Bhanot - Carlsbad CA, US

Assignee:

Isis Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

A61K 48/00
C07H 21/02
C07H 21/04

US Classification:

514 44, 536 231, 536 245, 536 2431, 536 2433

Abstract:

Disclosed herein are compounds, compositions and methods for modulating the expression of PTPRU in a cell, tissue or animal. Also provided are methods of active target segment validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, obesity, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hyperfattyacidemia, liver steatosis, steatohepatitis, non-alcoholic steatohepatitis, metabolic syndrome, cardiovascular disease and coronary heart disease by administration of antisense compounds targeted to PTPRU.

Author:

Robert W. McKay

ISBN #:

0590044354

Author:

Robert J. McKay

ISBN #:

0470838256

Author:

Robert J. McKay

ISBN #:

0471548022

Author:

Robert J. McKay

ISBN #:

0471641456

Author:

Robert J. McKay

ISBN #:

0878500022

Author:

Robert B. McKay

ISBN #:

0379207761

Author:

Robert B. McKay

ISBN #:

0394569938

Author:

Robert B. McKay

ISBN #:

0824791800

Address:

5 N Sagebrush St, Wichita, KS 67230

Phone:

316 218-1791

VIN:

5N3AA08C29N901762

Make:

INFINITI

Model:

QX56

Year:

2009