Robert A Jaffe

Author:

Robert L. Jaffe

ISBN #:

3540591575

Author:

Robert B. Jaffe

ISBN #:

0444005552

Author:

Robert B. Jaffe

ISBN #:

0721632068

Author:

Robert B. Jaffe

ISBN #:

0721668976

Author:

Robert B. Jaffe

ISBN #:

0721696252

Author:

Robert B. Jaffe

ISBN #:

0721696309

US Patent:

6821748, Nov 23, 2004

Filed:

May 28, 1998

Appl. No.:

09/086138

Inventors:

Robert L. Jaffe - Long Island City NY 11101

International Classification:

C12Q 118

US Classification:

435 32, 435 29

Abstract:

Cytoxotixc agent, and particularly DNA-damaging agents, can be detected in a whole effluent water or liquid sample by a method called whole effluent toxicity. A living culture of a particle-feeding flagellate is added to a sample, a growth rate is determined for the flagellate, and the growth rate is compared within the sample and its standard growth rate. A decrease in growth rate is indicative of cytotoxic agents in the sample.

US Patent:

7354579, Apr 8, 2008

Filed:

Jul 23, 2004

Appl. No.:

10/897802

Inventors:

Jocelyn Holash - Amaleda CA, US
Robert Jaffe - Tiburon CA, US
Limin Hu - San Francisco CA, US
George D. Yancopoulos - Yorktown Heights NY, US

Assignee:

Regeneron Pharmaceuticals, Inc. - Tarrytown NY

International Classification:

A61K 38/18
C07K 14/71
C12N 15/62

US Classification:

4241341, 4241921, 514 2, 514 12, 530350, 536 234

Abstract:

Methods of treating cancer and/or reducing or inhibiting tumor growth in a subject in need thereof, comprising administering pharmaceutical composition comprising a vascular endothelial cell growth factor (VEGF) antagonist, such as a VEGF trap, an anti-proliferative agent, such as taxol, and a pharmaceutically acceptable carrier.

US Patent:

20040224379, Nov 11, 2004

Filed:

Oct 22, 2002

Appl. No.:

10/258409

Inventors:

Robert Jaffe - Long Island City NY, US

International Classification:

C12Q001/02
C12Q001/22

US Classification:

435/029000, 435/031000, 435/283100

Abstract:

Toxic substances in a sample can be detected by combining the sample with a living culture of (), and monitoring () the morphological state and/or swimming behavior of the living culture of in the presence of the sample. Loss of coordination of swimming behavior of the is indicative of the presence of a toxic substance in the sample. The sample tested may be a solid or liquid sample, or it may be a gaseous sample (for example an air sample () which may contain an airborne toxin).

US Patent:

47714689, Sep 13, 1988

Filed:

Apr 17, 1986

Appl. No.:

6/853100

Inventors:

John S. Batchelder - Tarrytown NY
Raymond E. Bonner - Yorktown Heights NY
Byron E. Dom - North Salem NY
Robert S. Jaffe - Shenorock NY

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06K 900

US Classification:

382 8

Abstract:

A method and apparatus for automatic inspection of periodic patterns typically found on patterned silicon wafers, printed circuit board, and the like is disclosed herein. The method comprises an inspection algorithm of two parts: a low-level algorithm and a higher level algorithm which includes, therein the operation of the low-level algorithm. The low-level algorithm utilizes the known periodicity of the pattern to find defects by comparing identical cells in the periodic array. The high-level algorithm comprises applying the low-level algorithm, some number of times (N) in succession on the image. An accumulator image is formed by adding the results of the low-level algorithm to create a separate image array where the pixels relate to the number of times that the pixel in the original image was detected as defective by the low-level algorithm. The apparatus for implementing the above method comprises a parallel/pipeline architecture for high speed processing and RAM LUT's to implement a plurality of subtract and compare functions.

US Patent:

53875087, Feb 7, 1995

Filed:

May 14, 1992

Appl. No.:

7/883257

Inventors:

Robert L. Jaffe - Long Island City NY

International Classification:

C12Q 100
C12Q 102
C12N 110
C12N 100

US Classification:

435 32

Abstract:

Cytotoxic agents, and particularly DNA-damaging agents, can be detected in a sample by a method comprising the steps of (a) adding the sample to a living culture of Tetramitus rostratus in flagellate form, (b) determining the growth rate of the T. rostratus culture in the presence of the sample, and (c) comparing the growth rate of the T. rostratus culture in the presence of the sample to a standard growth rate. A decrease in growth rate is indicative of the presence of cytotoxic agents in the sample. The use of the flagellate T. rostratus allows this assay to be used on solid as well as liquid or gaseous samples because T. rostratus ingests particulate materials via a gullet.

US Patent:

49691988, Nov 6, 1990

Filed:

May 16, 1988

Appl. No.:

7/194610

Inventors:

John S. Batchelder - Tarrytown NY
Raymond E. Bonner - Yorktown Heights NY
Byron E. Dom - North Salem NY
Robert S. Jaffe - Shenorock NY

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06K 900

US Classification:

382 8

Abstract:

A method and apparatus for automatic inspection of periodic patterns typically found on patterned silicon wafers, printed circuit board, and the like is disclosed herein. The method comprises an inspection algorithm of two parts: a low-level algorithm and a higher level algorithm. The low-level algorithm utilizes the known periodically of the pattern to find defects by comparing identical cells in the periodic array. The high-level algorithm applies the low-level algorithm, some number of times (N) in succession on the image; accumulates defective pixels to form a separate image; and then applies a threshold-sort operation on a neighborhood to determine center pixel defectiveness. The apparatus for implementing the above method comprises a parallel/pipeline architecture for high speed processing and RAM LUT's to implement a plurality of subtract and compare functions.