Robert L Jacobs

US Patent:

6444697, Sep 3, 2002

Filed:

Jul 27, 2001

Appl. No.:

09/916470

Inventors:

Amy E. Wright - Fort Pierce FL
Robert S. Jacobs - Santa Barbara CA

Assignee:

Harbor Branch Oceanographic Instutition, Inc. - Fort Pierce FL
Regents of the University of California - Oakland CA

International Classification:

A61K 3140

US Classification:

514408, 514414, 514415, 514416, 514417, 514419

Abstract:

Novel uses of biologically active bis-heterocyclic e. g. bis-indole alkaloid compounds which have improved activity are disclosed. Pharmaceutical compositions containing the compounds are also disclosed. Specifically, the novel Utility pertains to the anti-immunogenic and neurogenic inflammatory properties exhibited by the bis-indole compounds and their analogs.

US Patent:

6495586, Dec 17, 2002

Filed:

Feb 23, 2001

Appl. No.:

09/790640

Inventors:

Robert S. Jacobs - Santa Barbara CA
Lisa A. Marshall - Collegeville PA
William H. Gerwick - Corvallis OR
Christopher Stevenson - King of Prussia PA

Assignee:

The Regents of the University of California - Oakland CA
Oregon State University - Corvallis OR
GlaxoSmithKline - King of Prussia PA

International Classification:

A61K 3140

US Classification:

514411

Abstract:

Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.

US Patent:

6495588, Dec 17, 2002

Filed:

Sep 24, 2001

Appl. No.:

09/960314

Inventors:

Robert S. Jacobs - Santa Barbara CA
Lisa A. Marshall - Collegeville PA
William H. Gerwick - Corvallis OR
Christopher Stevenson - Dana Point CA

Assignee:

The Regents of the University of California - Oakland CA
State of Oregon c/o Oregon State University - Corvallis OR
GlaxoSmithKline - King of Prussia PA

International Classification:

A61K 4338

US Classification:

514411, 435 6

Abstract:

Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.

US Patent:

6589975, Jul 8, 2003

Filed:

Aug 5, 2002

Appl. No.:

10/211370

Inventors:

Robert S. Jacobs - Santa Barbara CA
Claudia E. Moya - Santa Barbara CA
Amy E. Wright - Fort Pierce FL

Assignee:

The Regents of the University of California - Oakland CA
Harbor Branch Oceanographic Inst. - Fort Pierce FL

International Classification:

A61K 3140

US Classification:

514408, 514414, 514415, 514416, 514417, 514419

Abstract:

Novel uses of biologically active bis-heterocyclic e. g. bis-indole alkaloid compounds which have improved activity are disclosed. Pharmaceutical compositions containing the compounds are also disclosed. Specifically, the novel utility pertains to the anti-immunogenic and neurogenic inflammatory properties exhibited by the bis-indole compounds and their analogs.

US Patent:

6660767, Dec 9, 2003

Filed:

Feb 1, 2002

Appl. No.:

10/060317

Inventors:

Robert S. Jacobs - Santa Barbara CA
Leslie Wilson - Santa Barbara CA
Hamta Madari - Santa Barbara CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 3135

US Classification:

514457, 514 28

Abstract:

Compounds and compositions for stabilizing microtubules are disclosed. Also disclosed are methods of inhibiting, preventing, regulating, modulating, attenuating, stabilizing, or affecting microtubule formation or function. Methods of treating, preventing or inhibiting diseases and disorders associated with microtubule formation, function, or both by administering a microtubule stabilizing agent such as coumarin is also disclosed.

US Patent:

6787571, Sep 7, 2004

Filed:

Nov 27, 2001

Appl. No.:

09/993666

Inventors:

Robert S. Jacobs - Santa Barbara CA
Russell G. Kerr - Boca Raton FL

Assignee:

The Regents of the University of California - Oakland CA
Florida Atlantic University Board of trustees - Boca Raton FL

International Classification:

A61K 31122

US Classification:

514681, 552296

Abstract:

Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formula wherein R is a hydrogen, alkyl, aryl, hydroxyalkyl, cycloalkyl, cycloalkenyl, carboxylic acid, alkylamino or amide group having from 2 to 20 carbon atoms, R , R , and R are each independently hydrogen or an acyl residue having from 1 to 6 carbon atoms, R is hydrogen, CH , or CH OH, and R is an organo group such as a hydrocarbon having from 1 to 10 carbon atoms are disclosed. Other seco-pseudopterosins and compounds related to pseudopterosins are disclosed.

US Patent:

7060686, Jun 13, 2006

Filed:

Aug 2, 2004

Appl. No.:

10/903261

Inventors:

Robert S. Jacobs - Santa Barbara CA, US
Russell G. Kerr - Boca Raton FL, US

Assignee:

The Regents of the University of California - Oakland CA
Florida Atlantic University Board of Trustees - Boca Raton FL

International Classification:

A61K 31/70
A61K 31/122
C07C 13/48
C07C 15/20
C07H 15/24

US Classification:

514 25, 514 33, 514680, 514681, 514691, 536 181, 552296, 585 21, 585 26

Abstract:

Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formula.

US Patent:

7074938, Jul 11, 2006

Filed:

Nov 18, 2003

Appl. No.:

10/715281

Inventors:

Robert S. Jacobs - Santa Barbara CA, US
R. Daniel Little - Goleta CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07D 209/04

US Classification:

548455, 548452

Abstract:

Disclosed herein are methods for synthesizing biologically active bis-heterocyclic compounds, e. g. bis-indoles. In particular, methods for making Soritin compounds such as Soritin B, bis-(1H-indol-3-yl)-acetic acid methyl ester, Soritin C, bis-2,2-(1-methyl-indol-3-yl) acetic acid methyl ester, Soritin D, bis-2,2-(1-methyl-indol-3-yl) acetic acid and Soritin compositions comprising the Soritin compounds are disclosed. Also disclosed are pharmaceutical formulations comprising the Soritin compounds and Soritin compositions.

Author:

Robert Nelson Jacobs

ISBN #:

0786886846

Author:

Robert H. Jacobs

ISBN #:

0877032505

Author:

Robert H. Jacobs

ISBN #:

0877033633

Author:

Robert H. Jacobs

ISBN #:

0877033641

Author:

Robert D. Jacobs

ISBN #:

0807108464

Author:

Robert D. Jacobs

ISBN #:

0837172241

Author:

Robert Louis Jacobs

ISBN #:

0047800224

Author:

Robert Louis Jacobs

ISBN #:

0381982556