Kinetic Biomarker For Quantification Of Lymphoproliferation, Clonal Expansion, Recruitment And Trafficking In Lymphoid Tissues And Of The In Vivo Actions Of Antigens And Modulating Thereon
Mark K. Hellerstein - Kensington CA, US Robert Busch - Berkeley CA, US
Assignee:
KINEMED, INC. - Emeryville CA
International Classification:
A61K 49/00 A61P 35/00
US Classification:
424 92
Abstract:
The methods of the present invention allow for the measurement of proliferation, clonal expansion trafficking and/or recruitment of lymphocytes into lymphoid tissue in an in vivo setting. Proliferation, clonal expansion, recruitment and/or trafficking of lymphocytes are measured by using stable isotopes to label newly synthesized DNA, isolating the newly-labeled DNA, and quantifying enrichment of the isolated DNA with mass spectrometry or other appropriate techniques. Such methods are useful in screening candidate drugs for stimulatory or inhibitory effects on proliferation, clonal expansion, recruitment and/or trafficking of lymphocytes. The methods also allow for the discovery of therapeutic agents in disorders of immune regulation such as HIV infection and for optimizing vaccine efficacy.
The Endocrine GroupAlbany Medical Center Community Division/The Endocrine Group 1365 Washington Ave STE 300, Albany, NY 12206 518 489-4704 (phone), 518 489-0512 (fax)
Education:
Medical School University of Pennsylvania School of Medicine Graduated: 1978
Dr. Busch graduated from the University of Pennsylvania School of Medicine in 1978. He works in Albany, NY and specializes in Endocrinology, Diabetes & Metabolism and Diabetes. Dr. Busch is affiliated with Albany Medical Center and Albany Memorial Hospital.
Urology Medical 4601 W Us Hwy 90, Lake City, FL 32055 386 752-4189 (phone), 386 752-4213 (fax)
Education:
Medical School UMDNJ School of Osteopathic Medicine Graduated: 1987
Procedures:
Circumcision Cystoscopy Cystourethroscopy Kidney Stone Lithotripsy Prostate Biopsy Transurethral Resection of Prostate Hernia Repair Urinary Flow Tests Vaginal Repair Vasectomy
Conditions:
Abdominal Hernia Appendicitis Benign Prostatic Hypertrophy Bladder Cancer Breast Disorders
Languages:
English
Description:
Dr. Busch graduated from the UMDNJ School of Osteopathic Medicine in 1987. He works in Lake City, FL and specializes in General Surgery and Urology. Dr. Busch is affiliated with Lake City Medical Center, Shands Live Oak Regional Medical Center and Shands Starke Regional Medical Center.
Alamo Maxillofacial Surgical Associates PA 4499 Medical Dr STE 190, San Antonio, TX 78229 210 614-3915 (phone), 210 614-3918 (fax)
Education:
Medical School University of Texas Southwestern Medical Center at Dallas Graduated: 2007
Conditions:
Gingival and Periodontal Diseases Tempromandibular Joint Disorders (TMJ)
Languages:
English Spanish
Description:
Dr. Busch graduated from the University of Texas Southwestern Medical Center at Dallas in 2007. He works in San Antonio, TX and specializes in Oral & Maxillofacial Surgery. Dr. Busch is affiliated with Methodist Hospital.