Robert M Bitner

US Patent:

52643719, Nov 23, 1993

Filed:

Mar 23, 1992

Appl. No.:

7/855269

Inventors:

George P. Miljanich - Redwood City CA
Robert S. Bitner - Mountain View CA
Stephen S. Bowersox - Menlo Park CA
James A. Fox - Palo Alto CA
Karen L. Valentino - San Carlos CA
Donald H. Yamashiro - San Francisco CA
Makoto Tsubokawa - South San Francisco CA

Assignee:

Neurex Corporation - Menlo Park CA

International Classification:

G01N 33567
G01N 3368

US Classification:

436503

Abstract:

A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.

US Patent:

49786695, Dec 18, 1990

Filed:

Jun 8, 1989

Appl. No.:

7/363504

Inventors:

Jack D. Barchas - Stanford CA
Glen R. Elliott - Sunnyvale CA
Peter I. Adriaenssens - Palo Alto CA
Robert S. Bitner - Mountain View CA
Stephen S. Bowersox - Menlo Park CA
Laszlo Nadasdi - San Francisco CA

Assignee:

Neurex Corporation - Menlo Park CA

International Classification:

A61K 3144

US Classification:

514292

Abstract:

Compounds of formula I are useful for suppressing appetite, for altering macronutrient preferences, for suppressing obsessive-compulsive behavior, and for inhibiting cravings and substance abuse: ##STR1## wherein R. sub. 1 and R. sub. 3 are each independently H, hydroxy-alkyl, alpha-cyanoalkyl, SO. sub. 3 H, SO. sub. 2 NH. sub. 2, or C(O)R, where R is OH, NH. sub. 2, lower alkoxy, benzyloxy, or aliphatic amino acyl; R. sub. 2 and R. sub. 9 are each independently H, lower alkyl, benzyl, succinyl, or C(O)R. sub. 4, where R. sub. 4 is H, lower alkyl, hydrocarboxy-lower alkylene, or lower alkoxycarboxy-lower alkylene; and R. sub. 5, R. sub. 6, R. sub. 7, and R. sub. 8 are each independently H, halo, lower alkyl, hydroxy, lower alkoxy, or two adjacent radicals form methylenedioxy or ethylenedioxy; with the proviso that R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 5, R. sub. 6, R. sub. 7, R. sub. 8, and R. sub. 9 are not simultaneously H.

US Patent:

55590950, Sep 24, 1996

Filed:

Nov 12, 1991

Appl. No.:

7/789913

Inventors:

George P. Miljanich - Redwood CA
Stephen S. Bowersox - Menlo Park CA
James A. Fox - Palo Alto CA
Karen L. Valentino - San Carlos CA
Robert S. Bitner - West Lafayette IN
Donald H. Yamashiro - Cleveland Heights OH

Assignee:

Neurex Corporation - Menlo Park CA

International Classification:

A61K 3816

US Classification:

514 12

Abstract:

A method and compositions for reducing neuronal damage related to an ischemic condition in a mammalian subject are described. The method includes administration of a voltage-gated calcium channel-blocking compound to the subject, 4-24 hours after the onset of the ischemic condition. Such a calcium channel blocking compound is effective to block norepinephrine release in mammalian CNS neuronal cells and is characterized by specific, high affinity binding to omega-conotoxin MVIIA binding sites. Also disclosed are novel peptide structures useful in the treatment method of the invention.

US Patent:

51890208, Feb 23, 1993

Filed:

Aug 2, 1990

Appl. No.:

7/561766

Inventors:

George P. Miljanich - Redwood City CA
Robert S. Bitner - Mountain View CA
Stephen S. Bowersox - Menlo Park CA
James A. Fox - Palo Alto CA
Karen L. Valentino - San Carlos CA
Donald H. Yamashiro - San Francisco CA
Makoto Tsubokawa - South San Francisco CA

Assignee:

Neurex Corporation - Menlo Park CA

International Classification:

A61K 3702
C07K 706
C07K 708
C07K 710

US Classification:

514 12

Abstract:

A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.

US Patent:

54242185, Jun 13, 1995

Filed:

Nov 4, 1993

Appl. No.:

8/147714

Inventors:

George P. Miljanich - Redwood City CA
Robert S. Bitner - Mountain View CA
Stephen S. Bowersox - Menlo Park CA
James A. Fox - Palo Alto CA
Karen L. Valentino - San Carlos CA
Donald H. Yamashiro - San Francisco CA

Assignee:

Neurex Corporation - Menlo Park CA

International Classification:

A61K 4900
G01N 33567
G01N 3368

US Classification:

436503

Abstract:

A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.

US Patent:

50514032, Sep 24, 1991

Filed:

Nov 22, 1989

Appl. No.:

7/440094

Inventors:

George P. Miljanich - Redwood City CA
Robert S. Bitner - Mountain View CA
Stephen S. Bowersox - Menlo Park CA
James A. Fox - Palo Alto CA
Karen L. Valentino - San Carlos CA
Donald H. Yamashiro - San Francisco CA

Assignee:

Neurex Corporation - Menlo Park CA

International Classification:

A61K 3702
C07K 708
C07K 710

US Classification:

514 12

Abstract:

A method of reducing neuronal damage related to an ischemic condition in a human patient, such as stroke-induced damage, by administration of a binding/inhibitory omega-conotoxin peptide.