Robert H Abeles

US Patent:

47147776, Dec 22, 1987

Filed:

Jan 6, 1986

Appl. No.:

6/817762

Inventors:

Paul Dowd - Pittsburgh PA
Christopher Kaufman - Dravosburg PA
Robert H. Abeles - Newton Centre MA

Assignee:

University of Pittsburgh - Pittsburgh PA

International Classification:

C07C 6104

US Classification:

562506

Abstract:

The subject invention relates to novel cyclopropanone hydrate derivatives of the structural formula ##STR1## wherein R. sub. 1 and R. sub. 2 are selected from the group consisting of --H, --(CH. sub. 2). sub. n -- where n is an integer between 1 and 20, preferably 2 and 10, --COCH. sub. 2 NH. sub. 2, and ##STR2## and R. sub. 3 and R. sub. 4 selected from the group consisting of --H, --OH, 13 NH. sub. 2, --CN, --COOR. sub. 5, --COOH, --SH, --(CH. sub. 2). sub. n OH, --(CH. sub. 2). sub. n NH. sub. 2, --(CH. sub. 2). sub. n COOH, --(CH. sub. 2). sub. n COOR. sub. 5, --CCH. sub. 3 OH (CH. sub. 2). sub. n COOH, halogen and C. sub. 7 -C. sub. 10 arakyls, where n is an integer between 1 and 20, preferably 1 and 10, and R. sub. 5 is an alkyl radical having between 1 and 20, preferably 1 and 10, carbon atoms; and to a process for the synthesis thereof.

US Patent:

47270624, Feb 23, 1988

Filed:

Mar 17, 1986

Appl. No.:

6/840254

Inventors:

David Taub - Metuchen NJ
Robert H. Abeles - Newton Centre MA
Arthur A. Patchett - Westfield NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07K 506
C07K 508
A61K 3702
C07C10110

US Classification:

514 18

Abstract:

Described are 3-halovinylglycines and their amino acid dipeptide and oligopeptide conjugates, a new class of efficient antibacterial agents, pharmaceutical compositions containing them as active ingredients, and methods of synthesis. The compounds are thought to interfere in bacterial cell wall synthesis.

US Patent:

48066800, Feb 21, 1989

Filed:

Nov 12, 1987

Appl. No.:

7/119527

Inventors:

David Taub - Metuchen NJ
Robert H. Abeles - Newton Centre MA
Arthur A. Patchet - Westfield NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07C10106

US Classification:

562574

Abstract:

Described bare 3-halovinylglycines and their amino acid dipeptide and oligopeptide conjugates, a new class of efficient antibacterial agents, pharmaceutical compositions containing them as active ingredients, and methods of synthesis. The compounds are thought to interfere in bacterial cell wall synthesis.

US Patent:

50666436, Nov 19, 1991

Filed:

Jan 18, 1990

Appl. No.:

7/466803

Inventors:

Robert H. Abeles - Waltham MA
Michael H. Gelb - Seattle WA

Assignee:

Sandoz Ltd. - Basle

International Classification:

A61K 3702
C07K 510
C07K 706
C07K 708

US Classification:

514 18

Abstract:

A peptide optionally in isosteric form wherein a methylene group in the backbone chain is disubstituted, one or both substituents being fluorine and/or chlorine, in free form or in pharmaceutically acceptable salt form, such as a compound of formula I ##STR1## wherein the substituents have various significances, or an isosteric form thereof, is useful as an enzyme inhibitor. In particular, as a renin inhibitor, it is useful in the prophylaxis or treatment of hypertension and congestive heart failure. It is prepared by a process comprising the step of coupling two corresponding peptide residues optionally in isosteric form, or precursors thereof, and if required appropriately converting any resultant compound in precursor form.

Author:

Robert H. Abeles

ISBN #:

0867202122