Richard S Tobin

US Patent:

8450090, May 28, 2013

Filed:

Oct 6, 2009

Appl. No.:

12/574694

Inventors:

Martha Karen Newell - Holland TX, US
Richard Tobin - Aurora CO, US
Odbert Triplett - Little Rock AR, US

Assignee:

The Regents of the University of Colorado, a body corporate - Denver CO

International Classification:

C10L 1/19
C01B 3/32
C12P 7/62
C12N 1/12
C12N 1/14

US Classification:

435135, 44388, 252375, 504149, 4352541, 4352571

Abstract:

The invention relates to methods and products for producing fatty acids by manipulating metabolic function in plants and fungus. The fatty acids generated according to the invention may be useful in the production of biofuels.

US Patent:

20130056683, Mar 7, 2013

Filed:

Oct 6, 2010

Appl. No.:

13/500682

Inventors:

Martha Karen Newell - Holland TX, US
Richard Tobin - Aurora CO, US
Odbert Triplett - Little Rock AR, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE - Denver CO

International Classification:

C12P 7/64
C01B 3/00
C12N 1/13

US Classification:

252373, 435134, 4352572

Abstract:

The invention relates to methods and products for producing fatty acids by manipulating metabolic function in plants and fungus. The fatty acids generated according to the invention may be useful in the production of biofuels.

US Patent:

20130295047, Nov 7, 2013

Filed:

Jan 5, 2012

Appl. No.:

13/977944

Inventors:

Martha Karen Newell - Holland TX, US
Cassie L. Harvey - Salado TX, US
Richard Tobin - Aurora CO, US

Assignee:

Scott & White Healthcare - Temple TX
The Texas A&M University System - College Station TX

International Classification:

A61K 38/20
A61K 38/08
A61K 31/7088
A61K 38/16

US Classification:

424 852, 435375, 514 11, 514 216, 514 44 R

Abstract:

The disclosure relates to methods for treating disorders of the mucosal tract such as the gastrointestinal system by targeting CLIP molecules. The methods are based on that CLIP in the groove of MHC class I or II molecules of the cells lining the mucosal surfaces of the body, such as the gastrointestinal tract, provides protection from MHC Class II or MHC class I mediated cell death, and therefore are useful for treating, inhibiting the development of a multitude of illnesses and conditions of the mucosal tract, including autoimmune disease.

US Patent:

20220347180, Nov 3, 2022

Filed:

Sep 25, 2020

Appl. No.:

17/764043

Inventors:

- Denver CO, US
Richard Tobin - Aurora CO, US
Nabanita Mukherjee - Aurora CO, US
David Norris - Englewood CO, US
Martin D.` Carter - Golden CO, US

International Classification:

A61K 31/519
A61K 39/395
A61K 31/635
A61P 35/00

Abstract:

Disclosed herein are methods for using therapeutic compounds, for example BH3 mimetics such as MCL1 inhibitors, to treat patients that may have failed to respond to targeted or immunotherapy treatments. In several embodiments, methods for treating such patients include combining MCL1 inhibitors with immunotherapies to enhance immunotherapy treatment. For example, the combination of MCL1 inhibitors with immunotherapies is used to treat cancer, such as melanoma. In some embodiments, MCL1 inhibitory compounds and therapies may be useful in treating tissues or tumors having one or more MDSC cell expressing high levels of MCL1. In some embodiments, MCL1 and BCL2 inhibitory compounds and therapies comprising same may be used to treat one or more melanomas, for example cutaneous melanoma, melanoma subtypes selected from uveal, acral, and mucosal. In some embodiments, MCL1 inhibitory compounds and therapies comprising same may be used to treat one or more melanomas, for example uveal melanoma. In many embodiments the targeted cells or tissues may not have BRAF mutations.

US Patent:

20140234359, Aug 21, 2014

Filed:

Sep 21, 2012

Appl. No.:

14/346214

Inventors:

Martha Karen Newell - Holland TX, US
Richard Tobin - Aurora CO, US
Susannah K. Rogers - Holland TX, US

Assignee:

Viral Genetics, Inc. - San Marino CA
Scott & White Healthcare - Temple TX
The Texas A&M University System - College Station TX

International Classification:

A61K 39/12
A61K 39/39
C12Q 1/70
C07K 14/005
C12N 15/113

US Classification:

4241861, 4242041, 4241991, 514 44 A, 435 5

Abstract:

The invention relates to methods and related products for preventing and treating disease, based on the use of plant viral vaccines and plant viral defense strategies. The methods also involve the identification of appropriate therapeutic strategies for diseases such as cancers.

US Patent:

20140220000, Aug 7, 2014

Filed:

Apr 4, 2012

Appl. No.:

14/009944

Inventors:

Martha Karen Newell - Holland TX, US
Cassie L. Harvey - Salado TX, US
Richard Tobin - Aurora CO, US

Assignee:

Scott & White Healthcare - Temple TX
The Texas A&M University System - College Station TX

International Classification:

A61K 39/395
A61K 31/713
A61K 38/10

US Classification:

4241331, 4241721, 435375

Abstract:

The invention relates to methods for treating disorders by targeting CLIP molecules and MHC. The methods are useful for treating, inhibiting the development of, or otherwise dealing with diseases such as HIV, blood vessel proliferative disorder, cancer and fibrosis.

Author:

Richard J. Tobin

ISBN #:

0669024686

Author:

Richard J. Tobin

ISBN #:

0822310538

Author:

Richard J. Tobin

ISBN #:

0822310716

Author:

Richard Tobin

ISBN #:

0897301781

Author:

Richard B. Tobin

ISBN #:

0930376072

Author:

Richard L. Tobin

ISBN #:

0897301498

Author:

Richard S. Tobin

ISBN #:

0080369367

Author:

Richard S. Tobin

ISBN #:

0874348684