Richard Woodrow Simmons

US Patent:

20020061862, May 23, 2002

Filed:

Nov 13, 2001

Appl. No.:

09/992056

Inventors:

Timothy Billiar - Nevillewood PA, US
Edith Tzeng - Pittsburgh PA, US
David Geller - Pittsburgh PA, US
Richard Simmons - Pittsburgh PA, US
Larry Shears - Bethel Park PA, US
Andreas Nussler - Ulm, DE

Assignee:

University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

A61K048/00
A61K009/127
C12N015/861

US Classification:

514/044000, 435/320100, 424/450000, 435/456000

Abstract:

The invention provides a pharmaceutical composition comprising as an active ingredient a pharmaceutical agent comprising a DNA sequence that codes for a protein which possesses the biological activity of inducible nitrogen monoxide synthase (iNOS) and eukaryotic regulation elements, wherein the eukaryotic regulation elements result in the expression of said DNA sequence in eukaryotic cells, and a pharmaceutically acceptable carrier. The pharmaceutical agent can be complexed to liposomes.

US Patent:

42604150, Apr 7, 1981

Filed:

Dec 12, 1979

Appl. No.:

6/102607

Inventors:

Richard P. Simmons - Sewickley PA

Assignee:

Allegheny Ludlum Steel Corporation - Pittsburgh PA

International Classification:

C21C 534

US Classification:

75 60

Abstract:

An improved method of refining molten metal is disclosed comprising the steps of injecting a mixture of oxygen and an inert gas below the surface of molten metal at a high oxygen to inert gas ratio while utilizing from about 2. 5 to 12% of the injected inert gas to shroud the remainder of the injected gaseous mixture. The oxygen to inert gas ratio is progressively decreased as the carbon content in the molten metal decreases and the temperature of the molten metal increases. The improvement of the present invention comprises supplying dry air to the remainder of the injected gaseous mixture in a quantity sufficient for the nitrogen in the dry air to fulfill the inert gas requirements for the remainder of the injected gaseous mixture, and for the oxygen in the dry air to fulfill at least a portion of the oxygen requirements for the injected gaseous mixture.

US Patent:

57729948, Jun 30, 1998

Filed:

Jun 5, 1995

Appl. No.:

8/463908

Inventors:

Suzanne T. Ildstad - Pittsburgh PA
Richard L. Simmons - Pittsburgh PA
Camillo Ricordi - Miami Beach FL
Sherry M. Wren - Pittsburgh PA
Christina Kaufman - Munhall PA

Assignee:

The University of Pittsburgh - Pittsburgh PA

International Classification:

A01N 6300
C12N 1500

US Classification:

424 937

Abstract:

The present invention relates to mammalian hematopoietic facilitatory cells (FC). In particular, it relates to the isolation, characterization and uses of the FC. The FC of the present invention can be distinguished from all other known bone marrow cells by their morphology, cell surface phenotype and in vivo function. It has now been established that purified hematopoietic stem cells alone or bone marrow cells depleted of FC do not readily engraft in a recipient. When co-administered with other bone marrow cells, especially the hematopoietic stem cells into a recipient, the FC enhance their engraftment, without apparent adverse biologic activities. In fact, the ability of the FC to enhance the engraftment of bone marrow cells in esablishing lymphohematopoietic chimerism without producing graft versus host disease also induces donor-specific tolerance to permit the permanent acceptance of donor's cells, tissues and organs. Therefore, FC may have a wide range of applications, including, but not limited to, hematopoietic reconstitution by bone marrow transplantation for the treatment of cancers, anemias, autoimmunity, immunodeficiency, viral infections and metabolic disorders as well as facilitation of solid organ, tissue and cellular transplantation.

US Patent:

54686300, Nov 21, 1995

Filed:

Sep 28, 1994

Appl. No.:

8/314917

Inventors:

Timothy R. Billiar - Pittsburgh PA
Andreas K. Nussler - Pittsburgh PA
David A. Geller - Pittsburgh PA
Richard L. Simmons - Pittsburgh PA

Assignee:

University of Pittsburg of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

C12N 902
C12N 1553
C12N 1570
C12N 1579

US Classification:

435189

Abstract:

A human tissue inducible nitric oxide synthase cDNA clone is disclosed. A process for preparing this cDNA clone coding for human tissue inducible nitric oxide synthase and for expressing the human tissue inducible nitric oxide synthase protein are provided.

US Patent:

56585659, Aug 19, 1997

Filed:

Jun 24, 1994

Appl. No.:

8/265046

Inventors:

Timothy R. Billiar - Pittsburgh PA
Edith Tzeng - Pittsburgh PA
Andreas K. Nussler - Neu-Ulm, DE
David A. Geller - Pittsburgh PA
Richard L. Simmons - Pittsburgh PA

Assignee:

University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

A61K 4800

US Classification:

424 9321

Abstract:

The present invention discloses a full-length human hepatocyte iNOS cDNA clone and various gene therapy applications utilizing an iNOS DNA sequence. In preferred embodiments of the disclosed invention, iNOS-directed gene therapy involves specific targeting of a DNA sequence encoding a protein or protein fragment with iNOS biological activity for treating vascular diseases and disorders, antitumor applications and in response to certain microbial infections.

US Patent:

58829083, Mar 16, 1999

Filed:

Jun 5, 1995

Appl. No.:

8/465522

Inventors:

Timothy R.. Billiar - Pittsburgh PA
Andreas K. Nussler - Pittsburgh PA
David A. Geller - Pittsburgh PA
Richard L. Simmons - Pittsburgh PA

Assignee:

University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

C12N 902
C12N 1553
C12N 1570

US Classification:

435189

Abstract:

A human tissue inducible nitric oxide synthase cDNA clone is disclosed. A process for preparing this cDNA clone coding for human tissue inducible nitric oxide synthase and for expressing the human tissue inducible nitric oxide synthase protein are provided.

Author:

Richard E Simmons

ISBN #:

0882954547

Author:

Richard E Simmons

ISBN #:

1930546777

Author:

Richard Simmons

ISBN #:

0002554178

Author:

Richard Simmons

ISBN #:

0140238379

Author:

Richard Simmons

ISBN #:

0062708236

Author:

Richard Simmons

ISBN #:

0062716077

Author:

Richard Simmons

ISBN #:

0062720694

Author:

Richard Simmons

ISBN #:

0062720708

Address:

5921 Marshall Ave, Newport News, VA 23605

VIN:

1N4BA41EX7C853222

Make:

NISSAN

Model:

MAXIMA

Year:

2007