Paul N. Devine - Lincroft NJ Richard D. Tillyer - Westfield NJ Richard M. Heid - Brooklyn NY David M. Tschaen - Holmdel NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D40306
US Classification:
5462837
Abstract:
This invention relates to a key intermediate in the synthesis of an endothelin antagonist the synthesis of this key intermediate via an asymmetric conjugate addition reaction.
Paul N. Devine - Old Bridge NJ Richard M. Heid - East Brunswick NJ David M. Tschaen - Holmdel NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D29516
US Classification:
548571
Abstract:
This invention relates to a method for the stereoselective synthesis of a 2-aryloxycarboxylic acid using a chiral auxiliary to enhance the stereoselectivity of the alkylation of the. alpha. -halo acid with an aryloxy group.
Celgene
Associate Director
Celgene Jan 2016 - Apr 2019
Principal Scientist
Celgene Mar 2011 - Dec 9, 2016
Senior Scientist
Pfizer Jun 2006 - Apr 2010
Senior Research Scientist Ii
Merck Sep 2004 - Dec 2005
Senior Research Chemist
Education:
Columbia University In the City of New York 1999 - 2004
Doctorates, Doctor of Philosophy, Organic Chemistry
University of Illinois at Urbana - Champaign
Bachelors, Bachelor of Science, Chemistry
Skills:
Organic Synthesis Chemistry Clinical Development Organic Chemistry Clinical Trials Drug Discovery Drug Development Hplc Analytical Chemistry Medicinal Chemistry Chromatography