Paul N. Devine - Lincroft NJ Richard D. Tillyer - Westfield NJ Richard M. Heid - Brooklyn NY David M. Tschaen - Holmdel NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D40306
US Classification:
5462837
Abstract:
This invention relates to a key intermediate in the synthesis of an endothelin antagonist the synthesis of this key intermediate via an asymmetric conjugate addition reaction.
Paul N. Devine - Old Bridge NJ Richard M. Heid - East Brunswick NJ David M. Tschaen - Holmdel NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D29516
US Classification:
548571
Abstract:
This invention relates to a method for the stereoselective synthesis of a 2-aryloxycarboxylic acid using a chiral auxiliary to enhance the stereoselectivity of the alkylation of the. alpha. -halo acid with an aryloxy group.