Richard E Giles

Author:

Richard Giles

ISBN #:

0596101473

Author:

Richard Giles

ISBN #:

0596102305

Author:

Richard Giles

ISBN #:

0701625899

Author:

Richard Giles

ISBN #:

0814627099

Author:

Richard Giles

ISBN #:

0748761594

Author:

Richard Giles

ISBN #:

0864404522

US Patent:

45459878, Oct 8, 1985

Filed:

Dec 20, 1983

Appl. No.:

6/563939

Inventors:

Richard E. Giles - Alameda CA
David R. Stevens - Fremont CA
Gary P. Wiesehahn - Alameda CA

Assignee:

Advanced Genetics Research Institute - Oakland CA

International Classification:

A61K 3912

US Classification:

424 89

Abstract:

Novel vaccines of double-stranded RNA viruses are prepared by psoralen inactivation under mild conditions in an inert atmosphere, optionally in the presence of a mild singlet oxygen scavenger. The resulting inactivated virus can be used as a vaccine for inoculation of hosts to provide for the stimulation of the immune system to the virus.

US Patent:

46939814, Sep 15, 1987

Filed:

Oct 7, 1985

Appl. No.:

6/785354

Inventors:

Gary P. Wiesehahn - Alameda CA
Richard P. Creagan - Alta Loma CA
David R. Stevens - Fremont CA
Richard Giles - Alameda CA

Assignee:

Advanced Genetics Research Institute - Oakland CA

International Classification:

A61K 3912

US Classification:

435238

Abstract:

Vaccines employing inactivated viruses having improved retention of antigenic characteristics are prepared by psoralen-inactivation of the live virus in a non-oxidizing atmosphere. By excluding oxygen and other oxidizing species from the inactivation medium, degradation of the antigen characteristics resulting from irradiation with ultraviolet light is largely prevented. The resulting inactivated viruses are employed in vaccine preparations for the inoculation of susceptible hosts to inhibit viral infection.

US Patent:

47910623, Dec 13, 1988

Filed:

Jul 6, 1987

Appl. No.:

7/070201

Inventors:

Gary P. Wiesehahn - Alameda CA
Richard E. Giles - Union City CA
David R. Stevens - Fremont CA

Assignee:

Diamond Scientific Co. - Des Moines IA

International Classification:

A61K 3912
A61K 39245

US Classification:

435238

Abstract:

Novel vaccines for feline viral rhinotracheitis are prepared by psoralen inactivation of live Feline Herpesvirus I by exposure to ultraviolet radiation in the presence of an inactivating furocoumarin. The resulting inactivated viruses are suitable as the immunogenic substances in vaccines, which vaccines are useful for inoculation of hosts susceptible to feline virus rhinotracheitis.

US Patent:

51066190, Apr 21, 1992

Filed:

Jan 10, 1990

Appl. No.:

7/463081

Inventors:

Gary P. Wiesehahn - Alameda CA
Richard P. Creagan - Alta Loma CA
David R. Stevens - Fremont CA
Richard Giles - Alameda CA

Assignee:

Diamond Scientific Co. - Des Moines IA

International Classification:

A61K 3912
C12N 704

US Classification:

424 89

Abstract:

Vaccines employing inactivated viruses having improved retention of antigenic characteristics are prepared by psoralen-inactivation of the live virus in a non-oxidizing atmosphere. By excluding oxygen and other oxidizing species from the inactivation medium, degradation of the antigen characteristics resulting from irradiation with ultraviolet light is largely prevented. The resulting inactivated viruses are employed in vaccine preparations for the inoculation of susceptible hosts to inhibit viral infection.

US Patent:

45565562, Dec 3, 1985

Filed:

Mar 23, 1984

Appl. No.:

6/592661

Inventors:

Gary P. Wiesehahn - Alameda CA
Richard E. Giles - Alameda CA
David R. Stevens - Fremont CA

Assignee:

Advanced Genetics Research Institute - Oakland CA

International Classification:

H61K 3912

US Classification:

424 89

Abstract:

Novel vaccines for vesicular stomatitis virus are prepared by psoralen inactivation of the live virus under mild conditions in an inert atmosphere. The resulting inactivated virus can be used as a vaccine for inoculation of susceptible hosts to inhibit VSV infection.