15 York St, New Haven, CT 06510 203 785-4632 (Phone), 203 785-3315 (Fax)
YALE DERMATOLOGY ASSOCIATES 2 Church St S Suite 305, New Haven, CT 06519 203 789-1249 (Phone), 203 776-6188 (Fax)
YALE NEW HAVEN HOSPITAL PEDIATRIC HEMATOLOGY ONCOLOGY 333 Cedar St, New Haven, CT 06510 203 785-4640 (Phone), 203 737-2228 (Fax)
Certifications:
Dermatology, 1977
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
333 Cedar St Suite Lc1501, New Haven, CT 06510
15 York St, New Haven, CT 06510
YALE DERMATOLOGY ASSOCIATES 2 Church St S Suite 305, New Haven, CT 06519
YALE NEW HAVEN HOSPITAL PEDIATRIC HEMATOLOGY ONCOLOGY 333 Cedar St, New Haven, CT 06510
Yale - New Haven Hospital 20 York Street, New Haven, CT 06510
Education:
Medical School Yale University Graduated: 1970 Medical School U Chicago Hosp-Clins Graduated: 1970 Medical School Massachusetts General Hospital Graduated: 1970 Medical School Nih-Presby Hosp Graduated: 1970 Medical School National Institute Of Allergy and Infectious Disease Graduated: 1975
Dr. Richard N Edelson, Silver Spring MD - MD (Doctor of Medicine)
Medical School Harvard Medical School Graduated: 1966 Medical School Presby-St Lukes Hosp Graduated: 1966 Medical School New York Presbyterian Hospital-New York Weill Cornell Center Graduated: 1966
Dr. Richard C Edelson, New Haven CT - DC (Doctor of Chiropractic)
Sports Medicine Oregon 7300 SW Childs Rd STE B, Portland, OR 97224 503 692-8700 (phone), 503 692-8710 (fax)
Education:
Medical School Oregon Health & Science University School of Medicine Graduated: 1987
Procedures:
Arthrocentesis Knee Arthroscopy Shoulder Arthroscopy Shoulder Surgery
Conditions:
Ankylosing Spondylitis (AS) Fractures, Dislocations, Derangement, and Sprains Internal Derangement of Knee Internal Derangement of Knee Cartilage Internal Derangement of Knee Ligaments
Languages:
English
Description:
Dr. Edelson graduated from the Oregon Health & Science University School of Medicine in 1987. He works in Tigard, OR and specializes in Orthopaedic Surgery and Orthopedic Sports Medicine. Dr. Edelson is affiliated with Legacy Meridian Park Hospital, PeaceHealth Southwest Medical Center, Providence Saint Vincent Medical Center and Providence Willamette Falls Medical Center.
Yale Medical GroupYale Dermatology Associates 2 Church St S STE 305, New Haven, CT 06519 203 789-1249 (phone)
Education:
Medical School Yale University School of Medicine Graduated: 1970
Procedures:
Destruction of Benign/Premalignant Skin Lesions Skin Surgery
Conditions:
Dermatitis Skin Cancer Acne Alopecia Areata Atopic Dermatitis
Languages:
English Spanish
Description:
Dr. Edelson graduated from the Yale University School of Medicine in 1970. He works in New Haven, CT and specializes in Dermatology. Dr. Edelson is affiliated with Yale New Haven Hospital.
Dr. Edelson graduated from the Virginia Commonwealth University SOM in 1991. He works in Columbia, SC and 1 other location and specializes in Cardiovascular Disease. Dr. Edelson is affiliated with Palmetto Health Baptist, Palmetto Health Baptist Parkridge and Palmetto Health Richland Hospital.
Edelson & Associates 7511 New Ln Grange Rd, Louisville, KY 40222 502 423-1151 (phone), 502 423-1748 (fax)
Languages:
English
Description:
Dr. Edelson works in Louisville, KY and specializes in Neurology and Psychologist. Dr. Edelson is affiliated with Baptist Health Louisville, Jewish Hospital and Norton Hospital.
11 E 44 St, New York, NY 10017 350 Madison Ave, New York, NY 10017 646 758-6750
Richard Leslie Edelson
Edelson, Dr. Richard Dermatologist
2 Church St S, New Haven, CT 06519 203 789-1249
Richard L. Edelson Dermatology
Dermatology Associates, PC Medical Doctor's Office
2 Church St S, New Haven, CT 06519 203 787-4171
Richard L. Edelson Chair Of Cancer Committee
Yale-New Haven Hospital Hospital & Health Care · General Hospital Child Day Care Services · General Hospital Specialty Hospital · Specialty Hospital · Dermatologist · Ophthalmology · Colon Care · Surgeons
20 York St, New Haven, CT 06510 20 York St Rm Cb30, New Haven, CT 06510 15 York St, New Haven, CT 06510 203 688-4242, 203 688-2433, 203 453-7123, 203 785-3575
Richard Edelson Owner
Windows Windows Incorporated Whol Lumber/Plywood/Millwork
5 Rockland Pl, Greenwich, CT 06831
Richard L. Edelson Principal
Transimmune Business Services at Non-Commercial Site
Richard L. Edelson - Westport CT Francis P. Gasparro - Hamden CT Robert E. Tigelaar - Guilford CT
Assignee:
Yale University - New Haven CT
International Classification:
A01N 6300
US Classification:
424 931, 435325, 530300
Abstract:
Methods and pharmaceutical compositions for modifying the immune response of a mammal to a specific antigen are provided. The methods include treating an antigen presenting cell to enhance expression of a major histocompatibility complex molecule and reacting the treated antigen presenting cell with the antigen extracorporeally to form an antigen-associated antigen presenting cell.
Methods For Inducing The Differentiation Of Monocytes Into Functional Dendritic Cells
Richard Leslie Edelson - Westport CT 06880 Carole Berger - Riverdale, Bronx NY 10471
International Classification:
C12N 500
US Classification:
435377, 435 2, 435325, 435347, 435355, 435372
Abstract:
A method for inducing differentiation of monocytes contained in an extracorporeal quantity of a subjects blood into functional dendritic antigen presenting cells is provided. The monocytes are first treated by exposure to physical perturbation, irradiation in the presence of a photoactivatable agent capable of forming photoadducts with cellular DNA components, and/or treatment with a DNA binding agent. The treated monocytes are then incubated for a period of time sufficient to maximize the number of functional dendritic cells in the treated cell population. Functional dendritic cells generated from induced monocytes are incubated together with disease effector agents to enhance the presentation of at least one disease-causing antigen expressed by the disease effector agents.
Methods For Inducing The Differentiation Of Monocytes Into Functional Dendritic Cells
Richard Leslie Edelson - Westport CT 06880 Carole Berger - Riverdale, Bronx NY 10471
International Classification:
A01N 6300
US Classification:
424 937, 424 931, 435377, 435 2, 435325
Abstract:
A method for inducing differentiation of monocytes contained in an extracorporeal quantity of a subjects blood into functional dendritic antigen presenting cells is provided. The monocytes are first treated by exposure to physical perturbation, irradiation in the presence of a photoactivatable agent capable of forming photoadducts with cellular DNA components, and/or treatment with a DNA binding agent. The treated monocytes are then incubated for a period of time sufficient to maximize the number of functional dendritic cells in the treated cell population. Functional dendritic cells generated from induced monocytes are incubated together with disease effector agents to enhance the presentation of at least one disease-causing antigen expressed by the disease effector agents.
Methods For Inducing The Differentiation Of Monocytes Into Functional Dendritic Cells And Immunotherapeutic Compositions Including Such Dendritic Cells
Richard Leslie Edelson - Westport CT, US Carole Berger - Bronx NY, US Douglas Hanlon - Branford CT, US Michael Girardi - Madison CT, US
Assignee:
Yale University - New Haven CT
International Classification:
C12N 5/00
US Classification:
435377, 435366, 435325, 604 401, 604 501
Abstract:
A method for inducing differentiation of monocytes contained in an extracorporeal quantity of a subject's blood into functional dendritic antigen presenting cells is provided. The monocytes are induced to differentiate into dendritic cells by activation forces resulting from flow of the monocytes through a treatment apparatus having plastic channels. The interior surface of the plastic channel may be modified to increase the available surface area for interaction with blood monocytes. Platelets and serum protein may be removed from the blood prior to treatment to reduce or eliminate contamination of the plastic channel by these blood components. Functional dendritic cells generated from induced monocytes are incubated together with apoptotic or inactivated disease effector agents to enhance the presentation of at least one disease-causing antigen expressed by the disease effector agents. Compositions including dendritic cells derived from induced monocytes and compositions including such dendritic cells incubated with disease effector agents are also provided for use in immunotherapeutic treatment.
Method For Inducing Selectively Suppressed Immune Response To Transplanted Tissue Or Cells
Transimmunization methods incorporating skin immunologic challenges are described for either selectively suppressing the immune response of recipients of transplanted tissue or cells or monitoring induced anti-cancer immunity. In one embodiment, skin from the transplant donor is allografted to the transplant recipient to induce an immunological response to the transplanted skin. A quantity of blood is taken from the recipient and treated to render the T cells in the blood apoptotic and to induce differentiation of blood monocytes into dendritic cells. The treated blood is incubated and administered to the recipient to induce formation of suppressor T cell clones which reduce the number of T cells attacking the transplanted tissue or organ. This tolerogenic approach can be complemented by also feeding the immature dendritic cells apoptotic or necrotic cells from the organ donor. In a second embodiment, dendritic cells loaded with tumor antigens are injected intradermally to monitor the anti-cancer immunity induced by Transimmunization.
Method For Suppressing Immune System Response To Transplanted Tissue Or Cells
Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is treated to induce monocytes contained in the blood to differentiate and form dendritic cells. The maturation of the dendritic cells is truncated at a stage where the dendritic cells can inactivate T cell clones which would otherwise generate an undesired immune system response. The immature dendritic cells can be directly administered to the transplant recipient, or the dendritic cells can be co-incubated with the bone marrow or stem cell preparation, prior to transplantation, in order to suppress or eliminate anti-recipient donor T cells contaminating the bone marrow or stem cell preparation. The methods can be used to suppress graft versus host disease in recipients of transplanted bone marrow or stem cells, or to suppress rejection of transplanted organs or tissue.
Method For Inducing Selectively Suppressed Immune Response To Transplanted Tissue Or Cells
Transimmunization methods incorporating skin immunologic challenges are described for either selectively suppressing the immune response of recipients of transplanted tissue or cells or monitoring induced anti-cancer immunity. In one embodiment, skin from the transplant donor is allografted to the transplant recipient to induce an immunological response to the transplanted skin. A quantity of blood is taken from the recipient and treated to render the T cells in the blood apoptotic and to induce differentiation of blood monocytes into dendritic cells. The treated blood is incubated and administered to the recipient to induce formation of suppressor T cell clones which reduce the number of T cells attacking the transplanted tissue or organ. This tolerogenic approach can be complemented by also feeding the immature dendritic cells apoptotic or necrotic cells from the organ donor. In a second embodiment, dendritic cells loaded with tumor antigens are injected intradermally to monitor the anti-cancer immunity induced by Transimmunization.
Method For Suppressing Immune System Response To Transplanted Tissue Or Cells
Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is treated to induce monocytes contained in the blood to differentiate and form dendritic cells. The maturation of the dendritic cells is truncated at a stage where the dendritic cells can inactivate T cell clones which would otherwise generate an undesired immune system response. The immature dendritic cells can be directly administered to the transplant recipient, or the dendritic cells can be co-incubated with the bone marrow or stem cell preparation, prior to transplantation, in order to suppress or eliminate anti-recipient donor T cells contaminating the bone marrow or stem cell preparation. The methods can be used to suppress graft versus host disease in recipients of transplanted bone marrow or stem cells, or to suppress rejection of transplanted organs or tissue.