Richard Buzon

US Patent:

20040053959, Mar 18, 2004

Filed:

Aug 27, 2003

Appl. No.:

10/649247

Inventors:

Richard Buzon - Stonington CT, US
Michael Castaldi - Pawcatuck CT, US
Zhengong Li - East Lyme CT, US
David Ripin - Old Saybrook CT, US
Yong Tao - Salem CT, US

Assignee:

Pfizer Inc.

International Classification:

C07D471/02

US Classification:

514/303000, 546/119000

Abstract:

The present invention relates and intermediates to a novel process for preparing triazolo-pyridines of the formula I wherein Ris selected from the group consisting of hydrogen, (C-C)alkyl or other suitable substituents; Ris selected from the group consisting of hydrogen, (C-C)alkyl or other suitable substituents; s is an integer from 0-5; Ris hydrogen or a suitable substituent and to intermediates for their preparation. The compounds prepared by the methods of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.

US Patent:

20080293646, Nov 27, 2008

Filed:

Mar 12, 2008

Appl. No.:

12/047154

Inventors:

Thomas V. Magee - Mystic CT, US
Usa Reilly - West Haven CT, US
Mark Carl Noe - Mystic CT, US
Mark E. Flanagan - Gales Ferry CT, US
Zhengong Bryan Li - East Lyme CT, US
Richard Allen Buzon - Stonington CT, US
Daniel William Widlicka - Gales Ferry CT, US

International Classification:

A61K 31/7048
C07H 17/08
C07D 471/02
A61P 31/04

US Classification:

514 29, 536 74, 546122

Abstract:

The invention relates to compounds of Formula (I):wherein R, Rand X are as defined herein. The invention also relates to pharmaceutical compositions and methods of treating bacterial infections using compounds of Formula (I).