Richard D Antanavich

US Patent:

6372244, Apr 16, 2002

Filed:

Aug 25, 2000

Appl. No.:

09/648050

Inventors:

Richard D Antanavich - Paso Robles CA
Randel Dorian - Orlinda CA

Assignee:

Islet Sheet Medical, Inc. - San Francisco CA

International Classification:

A61F 1300

US Classification:

424423, 424422, 424424, 424425, 623 1111

Abstract:

Bioartificial implants and methods for their manufacture and use are described, particularly bioartificial pancreases. In particular, the implants may be thin sheets which enclose cells, may be completely biocompatible over extended periods of time and may not induce fibrosis. The high-density-cell-containing thin sheets are preferably completely retrievable, and have dimensions allowing maintenance of optimal tissue viability through rapid diffusion of nutrients and oxygen and also allowing rapid changes in the secretion rate of insulin and/or other bioactive agents in response to changing physiology. Implantations of living cells, tissue, drugs, medicines and/or enzymes, contained in the bioartificial implants may be made to treat and/or prevent disease.

US Patent:

61323969, Oct 17, 2000

Filed:

Aug 3, 1998

Appl. No.:

9/128374

Inventors:

Richard D. Antanavich - Paso Robles CA
Randel Dorian - Orinda CA

Assignee:

PlasmaSeal LLC - San Francisco CA

International Classification:

A61M 3700

US Classification:

604 82

Abstract:

A device and method for applying a fibrinogen-based tissue sealant to seamlessly connect human or animal tissues or organ parts, to seal wounds, stop bleeding and the like by mixing fibrin or fibrinogen with blood clot-promoting coagulation factors are disclosed. The device includes two cylindrical compartments for separately containing the separate fluid components of the sealant preparation, which are simultaneously displaced from the respective compartments by plungers commonly depressable with the same effective strokes. The plungers may be depressed directly or by a common mechanism (e. g. , rack and pinion) for accurately controlling the rate of dispensing fluid. The cylindrical compartments are of the same or different cross-sectional area and are arranged either concentrically or side-by-side. The device further includes structure for merging the two fluid components within an outer sleeve housing an inner needle. The sleeve and needle contain conduits for the flow of the two fluid sealant components as they are expressed from the respective compartments.

US Patent:

57886628, Aug 4, 1998

Filed:

Oct 22, 1996

Appl. No.:

8/736862

Inventors:

Richard D. Antanavich - Paso Robles CA
Randel Dorian - Orinda CA

Assignee:

Plasmaseal LLC - San Francisco CA

International Classification:

A61K 3516
B10D 6124

US Classification:

604 6

Abstract:

An inexpensive device with a disposable cartridge for preparing tissue sealant is disclosed. The device is particularly applicable to stat preparation of autologous tissue sealant. A method of sealing tissue in which the tissue sealant is applied immediately after mixing platelet-rich plasma concentrate (from the device) with a solution of calcium and thrombin is also disclosed. Preparation in the operating room of 5 cc sealant from 50 cc patient blood requires less than 15 minutes and only one simple operator step. There is no risk of tracking error because processing can be done in the operating room. Chemicals added may be limited to anticoagulant (e. g. , citrate) and calcium chloride. The disposable cartridge may fit in the palm of the hand and is hermetically sealed to eliminate possible exposure to patient blood and ensure sterility. Adhesive and tensile strengths are comparable or superior to pooled blood fibrin sealants made with precipitation methods.

US Patent:

58556133, Jan 5, 1999

Filed:

Oct 13, 1995

Appl. No.:

8/542506

Inventors:

Richard D. Antanavich - Paso Robles CA
Randel Dorian - Orinda CA

Assignee:

Islet Sheet Medical, Inc. - San Francisco CA

International Classification:

A61F 202

US Classification:

623 11

Abstract:

Bioartificial implants and methods for their manufacture and use are described, particularly bioartificial pancreases. In particular, the implants may be thin sheets which enclose cells, may be completely biocompatible over extended periods of time and may not induce fibrosis. The high-density-cell-containing thin sheets are preferably completely retrievable, and have dimensions allowing maintenance of optimal tissue viability through rapid diffusion of nutrients and oxygen and also allowing rapid changes in the secretion rate of insulin and/or other bioactive agents in response to changing physiology. Implantations of living cells, tissue, drugs, medicines and/or enzymes, contained in the bioartificial implants may be made to treat and/or prevent disease.

US Patent:

61652253, Dec 26, 2000

Filed:

Aug 3, 1998

Appl. No.:

9/128188

Inventors:

Richard D. Antanavich - Paso Robles CA
Randel Dorian - Orinda CA

Assignee:

Islet Sheet Medical LLC - San Francisco CA

International Classification:

A61F 202

US Classification:

623 2372

Abstract:

Bioartificial implants and methods for their manufacture and use are described, particularly bioartificial pancreases. In particular, the implants may be thin sheets which enclose cells, may be completely biocompatible over extended periods of time and may not induce fibrosis. The high-density-cell-containing thin sheets are preferably completely retrievable, and have dimensions allowing maintenance of optimal tissue viability through rapid diffusion of nutrients and oxygen and also allowing rapid changes in the secretion rate of insulin and/or other bioactive agents in response to changing physiology. Implantations of living cells, tissue, drugs, medicines and/or enzymes, contained in the bioartificial implants may be made to treat and/or prevent disease.

US Patent:

58140220, Sep 29, 1998

Filed:

Feb 6, 1996

Appl. No.:

8/595936

Inventors:

Richard D. Antanavich - Paso Robles CA
Randel Dorian - Orinda CA

Assignee:

Plasmaseal LLC - San Francisco CA

International Classification:

A61M 500

US Classification:

604191

Abstract:

A device and method for applying a fibrinogen-based tissue sealant to seamlessly connect human or animal tissues or organ parts, to seal wounds, stop bleeding and the like by mixing fibrin or fibrinogen with blood clot-promoting coagulation factors are disclosed. The device includes two cylindrical compartments for separately containing the separate fluid components of the sealant preparation, which are simultaneously displaced from the respective compartments by means of plungers commonly depressable with the same effective strokes. The plungers may be depressed directly or by means of a common mechanism (e. g. , rack and pinion) for accurately controlling the rate of dispensing fluid. The cylindrical compartments are of the same or different cross-sectional area and are arranged either concentrically or side-by-side. The device further includes a means for merging the two fluid components within an outer sleeve housing an inner needle.

US Patent:

56435940, Jul 1, 1997

Filed:

May 3, 1994

Appl. No.:

8/237290

Inventors:

Randel E. Dorian - Orinda CA
Kent C. Cochrum - Davis CA
Richard David Antanavich - Paso Robles CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61F 202
A01N 102
C12N 1102
B29C 3910

US Classification:

424424

Abstract:

A coating apparatus includes a rotary cup for forming beads and projecting them radially outwardly, and one or more collection basins surrounding the bead forming cup. The cup is adjustably rotatable about its central axis, and the collection basins are independently rotatable and positioned to collect the beads projected from the cup. The coating apparatus further includes an elevation adjustment system for axially adjusting the alignment of the cup with respect to the selected collection basins. The rotational speeds of the cup and the collection basins are selected so as to minimize the impact of the beads against a gelling solution in the collection basins. In use, a supply mixture is introduced into a mixing chamber of the cup. As the cup spins, the coated particles are propelled upwardly by the centrifugal force from the mixing chamber along the inner surface of the cup, and are projected radially outwardly, as beads, into the gelling solution in one of the selected basins. Since the cup and the basin are simultaneously rotated, the impact of the beads against the capture solution is significantly reduced.

US Patent:

62143387, Apr 10, 2001

Filed:

Apr 25, 2000

Appl. No.:

9/558080

Inventors:

Richard D. Antanavich - Paso Robles CA
Randel Dorian - Orinda CA

Assignee:

Plasmaseal LLC - San Francisco CA

International Classification:

A01N 6300
B01D 3315

US Classification:

424 9372

Abstract:

A plasma concentrate comprising one of platelets and platelet releasate and from 5 to 400 mg/ml of fibrinogen. The concentrate further includes a physiologically acceptable carrier comprising water and physiologically acceptable inorganic and organic ions at a physiologically acceptable concentration. The fibrinogen in the concentrate is not significantly denatured. A method for processing blood is further provided.