6299 Sanfield Ln, Kalamazoo, MI 49009 • 269 544-2556
Portage, MI
Zeeland, MI
Holland, MI
Byron Center, MI
Oshtemo, MI
Work
Company:
Zoetis
Feb 2013
Address:
Kalamazoo, MI
Position:
Research fellow
Education
Degree:
Doctor of Philosophy (Ph.D.)
School / High School:
Wayne State University
1986 to 1990
Specialities:
Organic Chemistry
Skills
Organic Synthesis • Process Optimization • Hplc • Chemistry • Lc Ms • Pharmaceutical Industry • Mass Spectrometry • Gmp • Chromatography • Nmr • Organic Chemistry • Purification
Industries
Pharmaceuticals
Us Patents
Process For The Synthesis Of 5-(4-Fluorophenyl)-1-[2-((2R,4R)-4-Hydroxy-6-Oxo-Tetrahydro-Pyran-2-Yl)-Ethyl]-2-Isopropyl-4-Phenyl-1H-Pyrrole-3-Carboxylic Acid Phenylamide
Donald Eugene Butler - Holland MI Randall Lee Dejong - Zeeland MI Jade Douglas Nelson - Holland MI Michael Gerard Pamment - Holland MI Timothy Lee Stuk - Holland MI
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
C07D41306
US Classification:
544141, 548517, 548561
Abstract:
An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
Process For The Synthesis Of 5-(4-Fluorophenyl)-1-[2-((2R,4R)-4-Hydroxy-6-Oxo-Tetrahydro-Pyran-2-Yl)-Ethyl]-2-Isopropyl-4-Phenyl-1-Pyrrole-3-Carboxylic Acid Phenylamide
Donald Eugene Butler - Holland MI, US Randall Lee DeJong - Zeeland MI, US Jade Douglas Nelson - Holland MI, US Michael Gerard Pamment - Holland MI, US Timothy Lee Stuk - Holland MI, US
Assignee:
Warner-Lambert Company, LLC - Morris Plains NJ
International Classification:
C07D 413/06 C07D 401/06 C07D 406/06
US Classification:
544141, 546208, 548517
Abstract:
An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
Process For The Synthesis Of 5-(4-Fluorophenyl)-1-[2-((2R,4R)-4-Hydroxy-6-Oxo-Tetrahydro-Pyran-2-Yl)-Ethyl]-2-Isopropyl-4-Phenyl-1-Pyrrole-3-Carboxylic Acid Phenylamide
Donald Eugene Butler - Holland MI, US Randall Lee Dejong - Zeeland MI, US Jade Douglas Nelson - Holland MI, US Michael Gerard Pamment - Holland MI, US Timothy Lee Stuk - Holland MI, US
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
C07D 405/02
US Classification:
548517
Abstract:
An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
Novel Process For The Synthesis Of 5-(4-Fluorophenyl)-1-[2-((2R,4R)-4-Hydroxy-6-Oxo-Tetrahydro-Pyran-2-Yl)-Ethyl]-2-Isopropyl-4-Phenyl-1H-Pyrrole-3-Carboxylic Acid Phenylamide
Donald Butler - Holland MI, US Randall DeJong - Zeeland MI, US Jade Nelson - Holland MI, US Michael Pamment - Holland MI, US Timothy Stuk - Holland MI, US
International Classification:
C 07D 4 7/02
US Classification:
548/517000
Abstract:
An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
Novel Process For The Synthesis Of 5-(4-Fluorophenyl)-1-[2-((2R,4R)-4-Hydroxy-6-Oxo- Tetrahydro-Pyran-2-Yl)-Ethyl]-2-Isopropyl-4-Phenyl-1H-Pyrrole-3-Carboxylic Acid Phenylamide
Donald Butler - Holland MI, US Randall Dejong - Zeeland MI, US Jade Nelson - Holland MI, US Michael Pamment - Holland MI, US Timothy Stuk - Holland MI, US
International Classification:
C07D413/14 C 07D 4 5/02
US Classification:
544/141000, 548/517000
Abstract:
An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
Novel Process For The Synthesis Of 5-(4-Fluorophenyl)-1-[2-((2R,4R-4-Hydroxy-6-Oxo-Tetrahydro-Pyran-2-Yl)-Ethyl]-2-Isopropyl-4-Phenyl-1H-Pyrole-3-Carboxylic Acid And Phenylamide
Donald Butler - Holland MI, US Randall DeJong - Zeeland MI, US Jade Nelson - Holland MI, US Michael Pamment - Holland MI, US Timothy Stuk - Holland MI, US
International Classification:
C07D 405/02
US Classification:
548517000
Abstract:
An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
Novel Process For The Synthesis Of 5-(4-Fluorophenyl)-1-[2-((2R,4R)-4-Hydroxy-6-Oxo-Tetrahydro-Pyran-2-Yl)-Ethyl]-2-Isopropyl-4-Phenyl-1H-Pyrrole-3-Carboxylic Acid Phenylamide
Donald Butler - Holland MI, US Randall Dejong - Zeeland MI, US Jade Nelson - Holland MI, US Michael Pamment - Holland MI, US Timothy Stuk - Holland MI, US
International Classification:
C07D 405/02
US Classification:
548517000
Abstract:
An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
Zoetis - Kalamazoo, MI since Feb 2013
Research Fellow
Pfizer-VMRD-Kalamazoo, MI - Kalamazoo, MI Jan 2006 - Feb 2013
Research Fellow
Pfizer - PGRD-Holland, MI; Kalamazoo, MI Sep 1990 - Jan 2006
Scientist to Research Fellow
Education:
Wayne State University 1986 - 1990
Doctor of Philosophy (Ph.D.), Organic Chemistry
Calvin College 1982 - 1986
Bachelor of Science (B.S.), Chemistry
Skills:
Organic Synthesis Process Optimization Hplc Chemistry Lc Ms Pharmaceutical Industry Mass Spectrometry Gmp Chromatography Nmr Organic Chemistry Purification
Youtube
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