The invention relates to certain stable vaccine compositions comprising a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof; at least one antigen; a dispersing agent; an adjuvant; a water soluble organic solvent; and saline or water or mixtures thereof. The invention further relates to stable compositions as described above of a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof, but without an antigen. The invention also relates to a method for preventing or controlling helminthiasis, infection by acarids and arthropod endo-and ectoparasites and bacterial and viral disease in warm-blooded animals by the parenteral administration of compositions of the invention. The invention further relates to a process for the preparation of the invention compositions.
High-Dose, Long-Lasting Ectoparasiticide For Extended Control
Robert Bruce Albright - Chalfont PA, US Shobhan Shashikant Sabnis - Pennington NJ, US Larry A. Kraft - Hightstown NJ, US Susan Holzmer - Ewing NJ, US Robert Alan Pollet - Yardley PA, US Ramune Marija Cobb - Newtown PA, US
Assignee:
Wyeth - Madison NJ
International Classification:
A01N 25/00
US Classification:
424405
Abstract:
The present invention provides a topical, high-dose, long-acting ectoparasiticide composition effective for protecting against ectoparasite infestation in a warm-blooded animal for a period of greater than about 6 weeks.Also provided is a method for the extension of the duration of activity of an ectoparasitcide.