Ramesh S Patel

US Patent:

20040248910, Dec 9, 2004

Filed:

Jun 17, 2004

Appl. No.:

10/871751

Inventors:

M. Leanna - Grayslake IL, US
Steven Hannick - Highland Park IL, US
Michael Rasmussen - Kenosha WI, US
Lakshmi Bhagavatula - Vernon Hills IL, US
Pulla Singam - Des Plaines IL, US
Bradley Gates - Mount Prospect IL, US
Lawrence Kolaczkowski - Gurnee IL, US
Ramesh Patel - Chicago IL, US
Greg Wayne - Vernon Hills IL, US
Greg Lannoye - Wildwood IL, US
Weijiang Zhang - Grayslake IL, US
Zhenping Tian - Grayslake IL, US
Kirill Lukin - Mundelein IL, US
Bikshandarkoil Narayanan - Mundelein IL, US
David Riley - Kenosha WI, US
Howard Morton - Gurnee IL, US
Cynthia Curty - Gurnee IL, US
Daniel Plata - Wadsworth IL, US
John Bellettini - Waukegan IL, US
Bhadra Shelat - Lake Forest IL, US
Tiffany Spitz - Highland Park IL, US

Assignee:

Medivir AB - Huddinge

International Classification:

A61K031/522
C07D487/12

US Classification:

514/263380, 544/276000

Abstract:

Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of Rand Ris an amino acid acyl group and the other of Rand Ris a —C(O)C-Csaturated or monounsaturated, optionally substituted alkyl and Ris OH or H; or a pharmaceutically acceptable salt thereof.

US Patent:

20050250795, Nov 10, 2005

Filed:

May 18, 2005

Appl. No.:

11/131646

Inventors:

M. Leanna - Grayslake IL, US
Steven Hannick - Highland Park IL, US
Michael Rasmussen - Kenosha WI, US
Lakshmi Bhagavatula - Vernon Hills IL, US
Pulla Singam - Des Plaines IL, US
Bradley Gates - Mount Prospect IL, US
Lawrence Kolaczkowski - Gurnee IL, US
Ramesh Patel - Chicago IL, US
Greg Wayne - Vernon Hills IL, US
Greg Lannoye - Wildwood IL, US
Weijiang Zhang - Grayslake IL, US
Zhenping Tian - Grayslake IL, US
Kirill Lukin - Mundelein IL, US
Bikshandarkoil Narayanan - Mundelein IL, US
David Riley - Kenosha WI, US
Howard Morton - Gurnee IL, US
Cynthia Curty - Gurnee IL, US
Daniel Plata - Wadsworth IL, US
John Bellettini - Waukegan IL, US
Bhadra Shelat - Lake Forest IL, US
Tiffany Spitz - Highland Park IL, US

Assignee:

Medivir AB - Huddinge

International Classification:

C07D473/12
A61K031/522

US Classification:

514263380, 544276000

Abstract:

Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of Rand Ris an amino acid acyl group and the other of Rand Ris a —C(O)C-Csaturated or monounsaturated, optionally substituted alkyl and Ris OH or H; or a pharmaceutically acceptable salt thereof.

US Patent:

55809898, Dec 3, 1996

Filed:

Jun 7, 1995

Appl. No.:

8/472448

Inventors:

James D. Ratajczyk - Waukegan IL
Juliette K. Busse - Winthrop Harbor IL
Sanjay R. Chemburkar - Gurnee IL
Daniel A. Dickman - Grayslake IL
Yi-Yin Ku - Buffalo Grove IL
Hemantkumar H. Patel - Waukegan IL
Ramesh R. Patel - Chicago IL
David P. Sawick - Wildwood IL
John N. Starr - Grayslake IL
Bhadra Shelat - Lake Forest IL
Harry O. Spiwek - Kenosha WI

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D33322
C07D30736

US Classification:

549 77

Abstract:

A process for preparing a compound of the structure I ##STR1## where A is oxygen and sulfur and R. sup. 1 is selected from the group consisting of hydrogen, halogen, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms, and trifluoromethyl, and R. sup. 2 is alkyl of one to four carbon atoms, comprising coupling a compound of formula II: ##STR2## where X is bromine or iodine, with an N-hydroxyurea compound of formula III: ##STR3## in the presence of a palladium catalyst followed by reaction of the product thus formed with an alkali metal isocyante. The compounds of formula I are inhibitors of the enzyme 5-lipoxygenase and are thus useful as therapeutic agents for the treatment of allergic and inflammatory disease conditions.

US Patent:

61843768, Feb 6, 2001

Filed:

Aug 6, 1998

Appl. No.:

9/130214

Inventors:

M. Robert Leanna - Grayslake IL
Steven M. Hannick - Highland Park IL
Michael Rasmussen - Kenosha WI
Lakshmi Bhagavatula - Vernon Hills IL
Pulla Reddy Singam - Des Plaines IL
Bradley D. Gates - Mount Prospect IL
Lawrence Kolaczkowski - Gurnee IL
Ramesh R. Patel - Chicago IL
Greg Wayne - Vernon Hills IL
Greg Lannoye - Wildwood IL
Weijiang Zhang - Grayslake IL
Zhenping Tian - Grayslake IL
Kirill A. Lukin - Mundelein IL
Bikshandarkoil A. Narayanan - Mundelein IL
David A. Riley - Kenosha WI
Howard Morton - Gurnee IL
Cynthia B. Curty - Gurnee IL
Daniel Plata - Wadsworth IL
John Bellettini - Waukegan IL
Bhadra Shelat - Lake Forest IL
Tiffany Spitz - Highland Park IL

Assignee:

Mediver AB - Huddinge

International Classification:

C07D47318
C07D47340
C07D31730
C07F 718
C12P 1718

US Classification:

544229

Abstract:

Methods and novel intermediates of the formula: ##STR1## wherein R. sub. 6 and R. sub. 7 are lower alkyl or benzyl or R. sub. 6 and R. sub. 7 taken together are --CH. sub. 2 CH. sub. 2 --, --CH. sub. 2 CH. sub. 2 CH. sub. 2 -- or --CH. sub. 2 CH. sub. 2 CH. sub. 2 CH. sub. 2 CH. sub. 2 --, R. sub. 8 is C. sub. 1 -C. sub. 21 alkyl or a C. sub. 2 -C. sub. 21 monounsaturated alkenyl, which may optionally be substituted with substitution substituents independently selected from the group consisting of hydroxy, C. sub. 1 -C. sub. 6 alkyl, C. sub. 1 -C. sub. 6 alkoxy, C. sub. 1 -C. sub. 6 alkoxy C. sub. 1 -C. sub. 6 alkyl, C. sub. 1 -C. sub. 6 alkanoyl, amino, halo, cyano, azido, oxo, mercapto and nitro, and R. sub. 9 is an alcohol protecting group. The intermediates are useful for the preparation of acyclic nucleoside derivatives of the formula: ##STR2## where one of R. sub. 1 and R. sub.

US Patent:

54120950, May 2, 1995

Filed:

May 20, 1994

Appl. No.:

8/246526

Inventors:

James A. Morley - Gurnee IL
John F. Bauer - Lake Bluff IL
Ramesh F. Patel - Chicago IL
Rodger E. Henry - Waukegan IL
Stephen G. Spanton - Grayslake IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31505
C07D23984

US Classification:

544291

Abstract:

The present invention provides a non-solvated crystalline polymorph of terazosin monohydrochloride designated Form III and methods for its preparation. Also disclosed is terazosin monohydrochloride methanolate and processes for its production as well as processes for its conversion to other crystalline forms of terazosin monohydrochloride.