Ramanujan S Hegde

US Patent:

6821742, Nov 23, 2004

Filed:

Dec 15, 2000

Appl. No.:

09/739179

Inventors:

Vishwanath R. Lingappa - San Francisco CA
D. Thomas Rutkowski - San Francisco CA
Ramanujan S. Hegde - Rockville MD

Assignee:

Regents of the University of California - Oakland CA

International Classification:

G01N 33567

US Classification:

435 721, 435 6, 435325, 435326, 536 235

Abstract:

Methods and compositions are provided for identifying novel conformers of proteins not known to exist as different conformers. By using chimeric genes replacing a native signal sequence with a different signal sequence resulting in the production of a conformer, one can compare the native protein with the product of the chimeric gene. Where the conformations are different, the different protein may be used for production of antibodies, elucidation of mechanisms associated with the native and different conformer protein, assays for the presence of the different conformer in physiological samples, identification of compounds specifically binding to the conformer, particularly drugs, etc. Where the formation of the conformer is associated with a diseased state, the conformer may be used in screens to identify compounds as drug candidates.

US Patent:

7041462, May 9, 2006

Filed:

Aug 3, 2004

Appl. No.:

10/911446

Inventors:

Vishwanath R. Lingappa - San Francisco CA, US
D. Thomas Rutkowski - San Francisco CA, US
Ramanujan S. Hegde - Rockville MD, US

Assignee:

Regents of the University of California - Oakland CA

International Classification:

A61K 33/567

US Classification:

435 72, 435328, 435 721, 435326, 536 235, 5303873, 4241331

Abstract:

Methods and compositions are provided for identifying novel conformers of proteins not known to exist as different conformers. By using chimeric genes replacing a native signal sequence with a different signal sequence resulting in the production of a conformer, one can compare the native protein with the product of the chimeric gene. Where the conformations are different, the different protein may be used for production of antibodies, elucidation of mechanisms associated with the native and different conformer protein, assays for the presence of the different conformer in physiological samples, identification of compounds specifically binding to the conformer, particularly drugs, etc. Where the formation of the conformer is associated with a diseased state, the conformer may be used in screens to identify compounds as drug candidates.

US Patent:

20050003438, Jan 6, 2005

Filed:

Aug 3, 2004

Appl. No.:

10/911421

Inventors:

Vishwanath Lingappa - San Francisco CA, US
D. Rutkowski - San Francisco CA, US
Ramanujan Hegde - Rockville MD, US

International Classification:

C12Q001/68
G01N033/53
C07H021/04
C12N005/06

US Classification:

435006000, 435007100, 435069100, 435320100, 435328000, 530388100, 536023530

Abstract:

Methods and compositions are provided for identifying novel conformers of proteins not known to exist as different conformers. By using chimeric genes replacing a native signal sequence with a different signal sequence resulting in the production of a conformer, one can compare the native protein with the product of the chimeric gene. Where the conformations are different, the different protein may be used for production of antibodies, elucidation of mechanisms associated with the native and different conformer protein, assays for the presence of the different conformer in physiological samples, identification of compounds specifically binding to the conformer, particularly drugs, etc. Where the formation of the conformer is associated with a diseased state, the conformer may be used in screens to identify compounds as drug candidates.

US Patent:

20050003454, Jan 6, 2005

Filed:

Aug 3, 2004

Appl. No.:

10/910986

Inventors:

Vishwanath Lingappa - San Francisco CA, US
D. Rutkowski - San Francisco CA, US
Ramanujan Hegde - Rockville MD, US

International Classification:

G01N033/53

US Classification:

435007100

Abstract:

Methods and compositions are provided for identifying novel conformers of proteins not known to exist as different conformers. By using chimeric genes replacing a native signal sequence with a different signal sequence resulting in the production of a conformer, one can compare the native protein with the product of the chimeric gene. Where the conformations are different, the different protein may be used for production of antibodies, elucidation of mechanisms associated with the native and different conformer protein, assays for the presence of the different conformer in physiological samples, identification of compounds specifically binding to the conformer, particularly drugs, etc. Where the formation of the conformer is associated with a diseased state, the conformer may be used in screens to identify compounds as drug candidates.

US Patent:

20060019318, Jan 26, 2006

Filed:

Jul 13, 2005

Appl. No.:

11/181631

Inventors:

Vishwanath Lingappa - San Francisco CA, US
D. Rutkowski - Ann Arbor MI, US
Ramanujan Hegde - Bethesda MD, US

International Classification:

G01N 33/53
A01K 67/00
C07H 21/04
C12P 21/06
C12N 5/06
G01N 33/567

US Classification:

435007200, 435069100, 435320100, 435326000, 530388100, 536023530, 800008000

Abstract:

Methods and compositions are provided for identifying novel conformers of proteins not known to exist as different conformers. By using chimeric genes replacing a native signal sequence with a different signal sequence resulting in the production of a conformer, one can compare the native protein with the product of the chimeric gene. Where the conformations are different, the different protein may be used for production of antibodies, elucidation of mechanisms associated with the native and different conformer protein, assays for the presence of the different conformer in physiological samples, identification of compounds specifically binding to the conformer, particularly drugs, etc. Where the formation of the conformer is associated with a diseased state, the conformer may be used in screens to identify compounds as drug candidates.

US Patent:

60156597, Jan 18, 2000

Filed:

Sep 16, 1997

Appl. No.:

8/931772

Inventors:

William J. Welch - San Francisco CA
Ramanujan Hegde - San Francisco CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A01N 5502
A01N 102

US Classification:

435 12

Abstract:

Thermotolerant phenotypes are developed in cells, tissues, organs and organisms by the administration of benzoquinonoid ansamycins such as herbimycin A and any of various analogs. The general stress tolerance resulting from this inducement offers benefits in a variety of ways, including rendering surgical patients more able to withstand the rigors of surgery, prolonging the shelf life of organs excised from organ donors, and prolonging the viability of tissue-cultured cells and organs.