Ralf M Luche

US Patent:

6551810, Apr 22, 2003

Filed:

Apr 20, 2000

Appl. No.:

09/557921

Inventors:

Ralf M Luche - Seattle WA
Bo Wei - Kirkland WA

Assignee:

Ceptyr, Inc. - Bothell WA

International Classification:

C12N 916

US Classification:

435196, 4353201, 435325, 4352523, 435 6, 536 232

Abstract:

Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-10, and polypeptide variants thereof that stimulate dephosphorylation of DSP-10 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-10 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

US Patent:

6645753, Nov 11, 2003

Filed:

Apr 24, 2000

Appl. No.:

09/564357

Inventors:

Ralf M. Luche - Seattle WA
Bo Wei - Kirkland WA

Assignee:

Ceptyr, Inc. - Bothell WA

International Classification:

C12N 1555

US Classification:

4352523, 435196, 4353201, 435 6, 536 232

Abstract:

Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-5, and polypeptide variants thereof that stimulate dephosphorylation of DSP-5 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-5 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

US Patent:

6649391, Nov 18, 2003

Filed:

Jul 19, 2000

Appl. No.:

09/619380

Inventors:

Ralf M. Luche - Seattle WA
Bo Wei - Kirkland WA

Assignee:

Ceptyr, Inc. - Bothell WA

International Classification:

C12N 916

US Classification:

435196, 4352523, 4353201, 435 6, 536 232, 530300, 530350

Abstract:

Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-11, and polypeptide variants thereof that stimulate dephosphorylation of DSP-11 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-11 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

US Patent:

6825021, Nov 30, 2004

Filed:

Sep 18, 2001

Appl. No.:

09/955732

Inventors:

Ralf M. Luche - Seattle WA
Bo Wei - Kirkland WA

Assignee:

Ceptyr, Inc. - Bothell WA

International Classification:

C12N 916

US Classification:

435196, 435440, 4352523, 4353201, 435536, 435 232

Abstract:

Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-15, and polypeptide variants thereof that stimulate dephosphorylation of DSP-15 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-15 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

US Patent:

6841369, Jan 11, 2005

Filed:

Apr 6, 2000

Appl. No.:

09/544517

Inventors:

Ralf M. Luche - Seattle WA, US
Bo Wei - Kirkland WA, US

Assignee:

Ceptyr, Inc. - Bothell WA

International Classification:

C12N 916
C12N 1555
C12Q 168

US Classification:

435196, 435 6, 4353201, 4352523, 536 232

Abstract:

Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-4, and polypeptide variants thereof that stimulate dephosphorylation of DSP-4 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-4 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

US Patent:

6852520, Feb 8, 2005

Filed:

Mar 16, 2000

Appl. No.:

09/527376

Inventors:

Ralf M. Luche - Seattle WA, US
Bo Wei - Kirkland WA, US

Assignee:

Ceptyr, Inc. - Bothell WA

International Classification:

C12N009/16
C12N001/21
C12N005/22
C12N015/52
C07H021/04

US Classification:

435196, 4352523, 4353201, 435325, 435366, 536 232

Abstract:

Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-2, and polypeptide variants thereof that stimulate dephosphorylation of DSP-2 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-2 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

US Patent:

6902919, Jun 7, 2005

Filed:

Feb 1, 2001

Appl. No.:

09/775925

Inventors:

Ralf M. Luche - Seattle WA, US
Bo Wei - Kirkland WA, US

Assignee:

CEPTYR, Inc. - Bothell WA

International Classification:

C12N009/12
C12N001/20
C12N015/00
C07H021/04
C07K001/00

US Classification:

435194, 4352523, 4353201, 536 232, 530350

Abstract:

Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatases DSP-12 and DSP-13, and polypeptide variants thereof that stimulate dephosphorylation of DSP-12 and DSP-13 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-12 and/or DSP-13 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

US Patent:

7029898, Apr 18, 2006

Filed:

Sep 4, 2003

Appl. No.:

10/655073

Inventors:

Ralf M. Luche - Seattle WA, US
Bo Wei - Kirkland WA, US

Assignee:

CEPTYR, Inc. - Bothell WA

International Classification:

C12N 9/16
C12N 1/20
C12N 15/00
C07H 21/04
A61K 38/00

US Classification:

435196, 4352523, 4353201, 536 232, 530300, 530350

Abstract:

Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-11, and polypeptide variants thereof that stimulate dephosphorylation of DSP-11 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-11 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.