Rakesh K Sindhi

US Patent:

20060275752, Dec 7, 2006

Filed:

Jun 5, 2006

Appl. No.:

11/447213

Inventors:

Rakesh Sindhi - Pittsburgh PA, US

Assignee:

University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

C12Q 1/70
G01N 33/567
G01N 33/554
G01N 33/53

US Classification:

435005000, 435007200, 435007320

Abstract:

The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a third party sample and combines the assessments of the multiple parameters to correlate the test reaction with a clinical event.

US Patent:

20130029372, Jan 31, 2013

Filed:

Apr 8, 2011

Appl. No.:

13/639428

Inventors:

Rakesh Sindhi - Pittsburgh PA, US
Chethan Ashokkumar - Pittsburgh PA, US

International Classification:

C12Q 1/04
G01N 21/64

US Classification:

435 34

Abstract:

Disclosed herein are methods for diagnosing or predicting B-cell rejection in a subject. In one example, for assessing transplant rejection, the method includes determining an antigen presenting index by comparing uptake of a donor antigen to uptake of a reference antigen in a biological sample obtained from the subject. In another example, for assessing GVHD, the method includes determining an antigen presenting index by comparing uptake of a recipient antigen to uptake of a reference antigen in a biological sample obtained from the subject.

US Patent:

20130217038, Aug 22, 2013

Filed:

Mar 19, 2013

Appl. No.:

13/847252

Inventors:

University of Pittsburgh - Of the Commonwealth System of Higher Education - , US
Rakesh Sindhi - Pittsburgh PA, US

Assignee:

University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

G01N 33/569

US Classification:

435 724

Abstract:

The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a third party sample and combines the assessments of the multiple parameters to correlate the test reaction with a clinical event.

US Patent:

20140057315, Feb 27, 2014

Filed:

Oct 11, 2013

Appl. No.:

14/052391

Inventors:

Rakesh Sindhi - Pittsburgh PA, US
Chethan AshokKumar - Pittsburgh PA, US

Assignee:

University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

G01N 33/50

US Classification:

435 34

Abstract:

Disclosed herein are methods for diagnosing or predicting acute cellular and/or humoral rejection in a subject. In one example, a method of assessing organ rejection includes contacting a first sample comprising antigen presenting cells (APCs) obtained from a subject in need of or having received an organ transplant with a donor antigen from a donor under conditions sufficient to induce uptake of the donor antigen; contacting a second sample comprising APCs obtained from the subject in need of or having received an organ transplant with a third-party antigen under conditions sufficient to induce uptake of the third-party antigen; and determining an antigen presenting index by determining a ratio of uptake of the donor antigen in the first sample to uptake of the third-party antigen in the second sample, wherein the ratio of greater than one indicates organ rejection and the APCs are monocytes or monocyte-derived cells.

US Patent:

20170343536, Nov 30, 2017

Filed:

Aug 16, 2017

Appl. No.:

15/678994

Inventors:

- Pittsburgh PA, US
Rakesh Sindhi - Pittsburgh PA, US

Assignee:

University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

G01N 33/50
C12Q 1/68
G01N 33/53
G01N 33/569

Abstract:

The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a third party sample and combines the assessments of the multiple parameters to correlate the test reaction with a clinical event.

US Patent:

20170254800, Sep 7, 2017

Filed:

Feb 14, 2017

Appl. No.:

15/432858

Inventors:

- Pittsburgh PA, US
Rakesh Sindhi - Pittsburgh PA, US

Assignee:

University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

G01N 33/50
G01N 33/569
C12Q 1/68
G01N 33/53

Abstract:

The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a third party sample and combines the assessments of the multiple parameters to correlate the test reaction with a clinical event.

US Patent:

20150377867, Dec 31, 2015

Filed:

Sep 10, 2015

Appl. No.:

14/850628

Inventors:

- Pittsburgh PA, US
Rakesh Sindhi - Pittsburgh PA, US

Assignee:

University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

G01N 33/50

Abstract:

The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a third party sample and combines the assessments of the multiple parameters to correlate the test reaction with a clinical event.