Rajendra R Mehta

US Patent:

6900191, May 31, 2005

Filed:

Jan 20, 1998

Appl. No.:

09/008957

Inventors:

Robert M. Moriarty - Oak Park IL, US
Raju A. Penmasta - Bolingbrook IL, US
Liang Guo - Bolingbrook IL, US
Munagala S. Rao - Westmont IL, US
Rajendra G. Mehta - Orland Park IL, US

Assignee:

OncQuest, Inc. - Chicago IL

International Classification:

A61K031/59
C07C401/00

US Classification:

514167, 552653

Abstract:

A compound of formula I: wherein R1 is hydrogen, R2 is —CH, R3 is —CH, and R4 is hydrogen, useful in cancer prevention and therapy.

US Patent:

8158574, Apr 17, 2012

Filed:

Dec 17, 2008

Appl. No.:

12/337167

Inventors:

Tapas Das Gupta - River Forest IL, US
Rajendra G. Mehta - Orland Park IL, US
Rajeshwari Mehta - Orland Park IL, US
Craig Beattie - Chicago IL, US

Assignee:

CDG Therapeutics, Inc. - Elk Grove Village IL

International Classification:

C07K 14/00

US Classification:

514 1, 530300

Abstract:

The present invention relates to compositions and methods comprising chemopreventive agents that may be cupredoxin(s) or variants, derivatives and structural equivalents of cupredoxins, and at least one other chemopreventive agent. Specifically, these compositions may comprise azurin from , and/or the 50-77 residue region of azurin (p28). The at least one other chemopreventive agent may comprise an antiestrogen such as Tamoxifen. The compositions of the invention may be used to prevent the development of premalignant lesions in mammalian cells, tissues and animals, and thus prevent cancer.