Rajappa Vaidyanathan

age ~53

from Glen Allen, VA

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Connected to:

Processes For The Preparation Of 3-(4-(2,4-Difluorobenzyloxy)-3-Bromo-6-Methyl-2-Oxopyridin-1(2H)-Yl)-N,4-Dimethylbenzamide
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US Patent:

7906536, Mar 15, 2011
Filed:

Dec 12, 2007
Appl. No.:

11/954883
Inventors:

Daniel Dukesherer - Saint Louis MO, US
Michael Mao - Chesterfield MO, US
Richard Vonder Embse - Saint Louis MO, US
Gopi Yalamanchili - Saint Louis MO, US
Rajappa Vaidyanathan - Groton CT, US
Brian Chekal - Niantic CT, US
George Klemm - Webster Groves MO, US
Ronald VanderRoest - Kalamazoo MI, US
Randy Geurink - Caledonia MI, US
Assignee:

Pfizer Inc - New York NY
International Classification:

A61K 31/44
US Classification:

514348
Abstract:

This invention is directed generally to processes for the preparation of compounds of Formula I:.

Phosphoric Acid Isomerization Of A 5 (10), 9 (11) - Diene Steroid To The Corresponding 4, 9-Diene Steriod
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US Patent:

20030109728, Jun 12, 2003
Filed:

Dec 10, 2002
Appl. No.:

10/315273
Inventors:

Rajappa Vaidyanathan - Portage MI, US
International Classification:

C07J001/00
US Classification:

552/505000, 552/636000
Abstract:

The invention is a process for the preparation of a -steroid of formula (II) which comprises contacting a -steroid of formula (I) with a phosphorous containing acid.

Method For Catalyzing Amidation Reactions
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US Patent:

20050059824, Mar 17, 2005
Filed:

Sep 9, 2004
Appl. No.:

10/938777
Inventors:

Rajappa Vaidyanathan - Portage MI, US
Vikram Kalthod - Mattawan MI, US
International Classification:

C07D279/12
C07D265/30
C07D263/34
C07D213/46
US Classification:

544059000, 544172000, 544386000, 546315000, 548194000, 548236000, 548530000, 562450000, 562459000
Abstract:

The invention provides a method of preparing a compound of formula 2 wherein Rand Rare as defined herein, by a catalytic amidation process in the presence of added carbon dioxide. The inventive methods show surprising rate enhancement relative to the corresponding uncatalyzed reaction.

Method Of Synthesizing Indolinone Compounds
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US Patent:

20060009510, Jan 12, 2006
Filed:

Jul 5, 2005
Appl. No.:

11/174892
Inventors:

Jeffrey Havens - Mattawan MI, US
Rajappa Vaidyanathan - Portage MI, US
International Classification:

C07D 209/36
A61K 31/404
US Classification:

514418000, 548484000
Abstract:

Disclosed are methods of preparing pyrrole compounds of formula 14 and indolinone compounds of formula 1 via a synthetic route wherein the amide sidechain on the pyrrole moiety is attached prior to pyrrole formation. The compounds 14 produced by the methods herein are useful in the synthesis of compounds of formula 1, which are useful in the treatment of abnormal cell growth, such as cancer.

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