Qing Dong

US Patent:

6593347, Jul 15, 2003

Filed:

Aug 27, 2001

Appl. No.:

09/938560

Inventors:

Upul K. Bandarage - Newton MA
Qing Dong - Cambridge MA
Xinqin Fang - Chestnut Hill MA
David S. Garvey - Dover MA
Gregory J. Mercer - Stoughton MA
Stewart K. Richardson - Tolland CT
Joseph D. Schroeder - Dedham MA
Tiansheng Wang - Concord MA

Assignee:

NitroMed, Inc. - Bedford MA

International Classification:

A61K 31445

US Classification:

514327, 5142262, 514291, 514365, 514374, 514375, 514378, 514393, 514404, 514406, 514411, 514416, 514419, 514423, 514427, 514428, 514431, 514448, 514450, 514532, 514539, 514545, 514621, 514640, 514658, 514676, 514709, 514719

Abstract:

The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.

US Patent:

20030207919, Nov 6, 2003

Filed:

May 8, 2003

Appl. No.:

10/431457

Inventors:

Upul Bandarage - Newton MA, US
Qing Dong - Cambridge MA, US
Xinqin Fang - Chestnut Hill MA, US
David Garvey - Dover MA, US
Gregory Mercer - Stoughton MA, US
Stewart Richardson - Tolland CT, US
Joseph Schroeder - Dedham MA, US
Tiansheng Wang - Concord MA, US

International Classification:

A61K031/445
A61K031/21
A61K031/405

US Classification:

514/317000, 514/319000, 514/419000, 514/509000

Abstract:

The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.

US Patent:

6297260, Oct 2, 2001

Filed:

Oct 29, 1999

Appl. No.:

9/429019

Inventors:

Upul K. Bandarage - Newton MA
Qing Dong - Cambridge MA
Xinqin Fang - Chestnut Hill MA
David S. Garvey - Dover MA
Gregory J. Mercer - Stoughton MA
Stewart K. Richardson - Tolland CT
Joseph D. Schroeder - Dedham MA
Tiansheng Wang - Concord MA

Assignee:

NitroMed, Inc. - Bedford MA

International Classification:

A61K 31445
C07D21154

US Classification:

514327

Abstract:

The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.