Ping Luo

US Patent:

6767550, Jul 27, 2004

Filed:

Jun 30, 2000

Appl. No.:

09/608488

Inventors:

Ping Luo - Berkeley CA
Alekha K. Dash - Omaha NE

Assignee:

Berkeley Advanced Biomaterials, Inc. - Berkeley CA

International Classification:

A61K 920

US Classification:

424426, 424422, 424423, 424424, 424425, 424464, 424472, 424489

Abstract:

A hydroxyapatite based bioresorbable material is incorporated with anti-cancer agents to form an implant used for treatment against cancer. Sustained release of the anti-cancer agents may be achieved after implantation at the targeted sites. The dosage of the anti-cancer agent, the microstructure, morphology, and composition of the bioresorbable material allow control of the release profile. The invented implant may be used for drug delivery, chemotherapy, or gene therapy.

US Patent:

7237256, Jun 26, 2007

Filed:

Jul 14, 2003

Appl. No.:

10/619657

Inventors:

Qingwen Cheng - Fremont CA, US
Bhavna Bhatnagar - Sunnyvale CA, US
Hong Xu - Palo Alto CA, US
Wei Sun - Los Altos CA, US
Ping Luo - Union City CA, US
Shivaram Bhat - Sunnyvale CA, US
Aravindan Ranganathan - San Jose CA, US

Assignee:

Sun Microsystems, Inc. - Santa Clara CA

International Classification:

H04L 9/32

US Classification:

726 3, 726 4, 726 8

Abstract:

Embodiments of the present invention provide an open and interoperable single sign-on session in a heterogeneous communication network. The open and interoperable single sign-on system is configured by exchanging an entity identifier, an account mapping, an attribute mapping, a site attribute list, an action mapping and/or the like. The entity identifier, account mapping, attribute mapping, site attribute list, action mapping and the like for each partner entity is stored in a partner list accessable to the particular entity. Thereafter, the open and interoperable single sign-on session may be provided upon receipt of a SAML request or assertion containing an entity identifier. The entity identifier contained in the SAML request or assertion is looked-up in the partner list of the particular entity which received the SAML request or assertion. A record containing a matching entity identifier provides the applicable account mapping, attribute mapping, site attribute list, and/or action mapping. The one or more mappings are then utilized to process the SAML request or assertion.

US Patent:

20030055512, Mar 20, 2003

Filed:

May 21, 2001

Appl. No.:

09/862206

Inventors:

Francois Genin - Berkeley CA, US
Ping Luo - Berkeley CA, US

International Classification:

A61F002/28

US Classification:

623/023560, 623/023510, 606/076000

Abstract:

An injectable and moldable putty comprising biodegradable calcium-based compounds including calcium sulfate, hydroxyapatite, and tricalcium phosphate is invented. The putty hardens into a solid body when mixed with water, saline, serum, or other neutral aqueous solutions. The hardening time of the putty can be tailored in order to meet the specific requirements of various dental or orthopedic applications. The pH of the putty is neutral during and after mixing. The invented putty may be used as bone graft, bone implant, or implantable drug delivery device.

US Patent:

20070026030, Feb 1, 2007

Filed:

Jul 27, 2005

Appl. No.:

11/189711

Inventors:

Ken Gill - San Francisco CA, US
Ken Trauner - San Francisco CA, US
Francois Genin - Berkeley CA, US
Ping Luo - Berkeley CA, US

International Classification:

A61F 2/28
A61K 35/32
A61K 33/06

US Classification:

424423000, 623016110, 424682000, 424426000, 424549000

Abstract:

Methods of mixing delivering biocompatible cement, paste, putty, or gel for bone and cartilage repair are described in this invention. Powder-like solid materials are loaded into a first syringe. Liquids are loaded into one or multiple syringes. The liquids are injected into the first syringe containing the solid materials. To force the liquids through the solid, prevent bubble formation and provide intimate intermixing, the liquids are injected in the very proximity of the plunger end of the syringe containing the solid materials. The first syringe is preferably held vertical with the tip facing up so as to avoid bubble formation that in turn could cause back-pressure build-up and plug the first syringe during injection. The described methods of mixing the liquids with the solids allows to form a rheological paste, cement, putty, or gel in the first syringe. As injection into the human or animal body proceeds, the paste then flows without complications often caused by entrapped bubbles or improper/heterogeneous mixing. The preparation and injection processes can be conducted at temperatures that do not damage live tissue or denature proteins. The paste, cement, putty, or gel can be injected into bone through the cannula by hand or with a pressurizing system. The method reduces the amount of time needed to prepare the paste and load it into the syringe and provides a device that is easily prepared for injection.

US Patent:

20070190102, Aug 16, 2007

Filed:

Aug 9, 2004

Appl. No.:

10/913689

Inventors:

Ping Luo - Emeryville CA, US

International Classification:

A61F 2/02

US Classification:

424423000, 427002240

Abstract:

A bioresorbable material is incorporated with bioactive agents to form an implant used for treatment against hard tissue or soft tissue defects and diseases. Antibiotics or anti-cancer agents are incorporated to treat hard or soft tissue infections or cancers. Sustained release of the bioactive agents or drug molecules may be achieved after implantation at the targeted sites. The dosage of the active agents or molecules, the microstructure, morphology, and composition of the bioresorbable material allow control of the release profile. The invented implant may be used for drug delivery, chemotherapy, or gene therapy. Various microstructure and the morphologies of the implants are injectable like putty or shaped with multilayers.

US Patent:

20090318982, Dec 24, 2009

Filed:

Sep 1, 2009

Appl. No.:

12/552236

Inventors:

Francois GENIN - Berkeley CA, US
Ping LUO - Berkeley CA, US

Assignee:

Berkeley Advanced Biomaterials, Inc. - Berkeley CA

International Classification:

A61B 17/58

US Classification:

606 86 R

Abstract:

An injectable and moldable putty comprising biodegradable calcium-based compounds including calcium sulfate, hydroxyapatite, and tricalcium phosphate is invented. The putty hardens into a solid body when mixed with water, saline, serum, or other neutral aqueous solutions. The hardening time of the putty can be tailored in order to meet the specific requirements of various dental or orthopedic applications. The pH of the putty is neutral during and after mixing. The invented putty may be used as bone graft, bone implant, or implantable drug delivery device.

US Patent:

59946091, Nov 30, 1999

Filed:

Dec 16, 1997

Appl. No.:

8/991396

Inventors:

Ping Luo - Berkeley CA

International Classification:

G21F 900

US Classification:

588 2

Abstract:

Methods are provided for treating liquid hazardous waste containing anionic radioactive or heavy metal materials by binding the hazardous waste to hydroxyapatite powder, drying and then cold or hot pressing the hydroxyapatite powder into a solid mass for storage or disposal. The methods are useful for treatment and storage of radioactive waste, anions, and heavy metals. Methods are also provided for treating high concentration liquid hazardous waste and liquid hazardous waste which does not contain materials known to decompose at high temperatures.

US Patent:

58583181, Jan 12, 1999

Filed:

Nov 27, 1996

Appl. No.:

8/757849

Inventors:

Ping Luo - Berkeley CA

International Classification:

C01B 2532

US Classification:

423308

Abstract:

Methods are provided for producing non-porous controlled morphology hydroxyapatite granules of less than 8. mu. m by a spray-drying process. Solid or hollow spheres or doughnuts can be formed by controlling the volume fraction and viscosity of the slurry as well as the spray-drying conditions. Methods of providing for homogenous cellular structure hydroxyapatite granules are also provided. Pores or channels or varying size and number can be formed by varying the temperature at which a hydroxyapatite slurry formed in basic, saturated ammonium hydroxide is spray-dried. Methods of providing non-porous controlled morphology hydroxyapatite granules in ammonium hydroxide are also provided. The hydroxyapatite granules and bulk materials formed by these methods are also provided.