Srinivasa Rao Akireddy - Winston-Salem NC, US Balwinder Singh Bhatti - Winston-Salem NC, US Timothy J. Cuthbertson - Winston-Salem NC, US Gary Maurice Dull - Lewisville NC, US Craig Harrison Miller - Winston-Salem NC, US Julio A. Munoz - Walnut Cove NC, US Pieter Albert Otten - King NC, US
Assignee:
Targacept, Inc. - Winston-Salem NC
International Classification:
C07D 403/06
US Classification:
544242, 514256
Abstract:
The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-yl)pyrimidine, novel salt forms, and novel polymorphic forms of these salts.
Synthesis And Novel Salt Forms Of (R)-3-((E)-Pyrrolidin-3-Yl)Vinyl)-5-Tetrahydropyran-4-Yloxy)Pyridine
Srinivasa Rao Akireddy - Winston-Salem NC, US Scott R. Breining - Winston-Salem NC, US Timothy J. Cuthbertson - Winston-Salem NC, US Gary Maurice Dull - Lewisville NC, US Gregory J. Gatto - Winston-Salem NC, US John Genus - Winston-Salem NC, US Philip S. Hammond - Pinnacle NC, US Julio A. Munoz - Walnut Cove NC, US Pieter Albert Otten - King NC, US Daniel Yohannes - Winston-Salem NC, US Nikolai Fedorov - Winston-Salem NC, US
Assignee:
Targacept, Inc. - Winston-Salem NC
International Classification:
A61K 31/4433 C07D 405/14
US Classification:
514343, 5462764
Abstract:
The present invention relates to (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine, its salt forms, and to processes for the commercial-scale production of these compounds in sufficient purity and quality for use in pharmaceutical compositions.
Synthesis And Novel Salt Forms Of (R)-5-((E)-2-Pyrrolidin-3Ylvinyl)Pyrimidine
Balwinder Singh Bhatti - Winston-Salem NC, US Timothy J. Cuthbertson - Winston-Salem NC, US Gary Maurice Dull - Lewisville NC, US Craig Harrison Miller - Winston-Salem NC, US Joseph Pike Mitchener - Winston-Salem NC, US Julio A. Munoz - Walnut Cove NC, US Pieter Albert Otten - King NC, US
Assignee:
Targacept, Inc. - Winston-Salem NC
International Classification:
C07D 403/06 C07C 59/255
US Classification:
514256, 544242
Abstract:
The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of these salts.
Synthesis And Novel Salt Forms Of (R)-5-((E)-2-Pyrrolidin-3-Ylvinyl)Pyrimidine
- Princeton NJ, US Balwinder Singh BHATTI - Winston-Salem NC, US Timothy J. CUTHBERTSON - Winston-Salem NC, US Gary Maurice DULL - Lewisville NC, US Craig Harrison MILLER - Winston-Salem NC, US Julio A. MUNOZ - Walnut Cove NC, US Pieter Albert OTTEN - King NC, US
International Classification:
C07D 403/06 C07C 59/255 A61K 31/4025 C07C 59/265
Abstract:
The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of these salts.
Synthesis And Novel Salt Forms Of (R)-5-((E)-2-Pyrrolidin-3-Ylvinyl)Pyrimidine
- Princeton NJ, US Balwinder Singh BHATTI - Winston-Salem NC, US Timothy J. CUTHBERTSON - Winston-Salem NC, US Gary Maurice DULL - Lewisville NC, US Craig Harrison MILLER - Winston-Salem NC, US Julio A. MUNOZ - Walnut Cove NC, US Pieter Albert OTTEN - King NC, US
International Classification:
C07D 403/06 C07C 59/265 A61K 31/4025 C07C 59/255
Abstract:
The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of these salts.
Novel Salt Forms Of (R)-5-((E)-2-Pyrrolidin-3-Ylvinyl)Pyrimidine
- Princeton NJ, US Balwinder Singh BHATTI - Winston-Salem NC, US Timothy J. CUTHBERTSON - Winston-Salem NC, US Gary Maurice DULL - Lewisville NC, US Craig Harrison MILLER - Winston-Salem NC, US Julio A. MUNOZ - Walnut Cove NC, US Pieter Albert OTTEN - King NC, US
International Classification:
C07D 403/06 C07C 59/265 C07C 59/255 A61K 31/4025
Abstract:
The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of these salts.
Synthesis And Novel Salt Forms Of (R)-5-((E)-2-Pyrrolidin-3-Ylvinyl)Pyrimidine
- South San Francisco CA, US Balwinder Singh Bhatti - Winston-Salem NC, US Timothy J. Cuthbertson - Winston-Salem NC, US Gary Maurice Dull - Lewisville NC, US Craig Harrison Miller - Winston-Salem NC, US Julio A. Munoz - Walnut Cove NC, US Pieter Albert Otten - King NC, US
International Classification:
C07D 403/06 C07C 59/255 C07C 59/265 A61K 31/4025
Abstract:
The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of these salts.
Synthesis And Novel Salt Forms Of (R)-5-((E)-2-Pyrrolidin-3Ylvinyl)Pyrimidine
- Winston-Salem NC, US Balwinder Singh Bhatti - Winston-Salem NC, US Timothy J. Cuthbertson - Winston-Salem NC, US Gary Maurice Dull - Lewisville NC, US Craig Harrison Miller - Winston-Salem NC, US Joseph Pike Mitchener - Winston-Salem NC, US Julio A. Munoz - Walnut Cove NC, US Pieter Albert Otten - King NC, US
International Classification:
C07D 403/06 C07C 59/265
Abstract:
The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of these salts.
Apr 2008 to 2000 Senior Staff Scientist, Process ChemistryVertex Pharmaceuticals, Inc San Diego, CA Jan 2006 to Apr 2008 Scientist II, Process ChemistryChemBridge Research Laboratories San Diego, CA Mar 2001 to Dec 2005 Group Leader, Sr. Scientist IIUniversity of Texas Southwestern Medical Center, Department of Radiology Dallas, TX Jan 2000 to Feb 2001 Research AssociateNational Institute of Environmental Health Sciences Research Triangle Park, NC Jun 1996 to Dec 1999 Visiting Fellow
Education:
Michigan State University Jan 2011 to Jan 2011 Certification in Chemical Engineering I and IILeiden University Leiden Apr 1996 Ph.D. in ChemistryState University of Utrecht Nov 1991 M.S.
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