Phillip Lewis Cook

Address:

8715 Redwood Bnd, Helotes, TX 78023

Phone:

254 771-9071

VIN:

2HNYD28287H500352

Make:

ACURA

Model:

MDX

Year:

2007

US Patent:

6414135, Jul 2, 2002

Filed:

Jul 7, 1999

Appl. No.:

09/349035

Inventors:

Phillip Dan Cook - Fallbrook CA
Haoyun An - Carlsbad CA
Tingmin Wang - San Marcos CA
Muthiah Manoharan - Carlsbad CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07H 2100

US Classification:

536 253

Abstract:

The present invention is directed to nucleoside monomers wherein the 3â-O atom is replaced with a methylene group. The present invention also provides oligomers comprising a plurality of such monomers which are linked by methylenephosphonate linkages. Further, methods of preparing monomers and oligomers according to the present invention are provided.

US Patent:

6440943, Aug 27, 2002

Filed:

Jul 14, 1999

Appl. No.:

09/352058

Inventors:

Phillip Dan Cook - Fallbrook CA
Muthiah Manoharan - Carlsbad CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

A61K 3170

US Classification:

514 43, 536 221, 536 231, 536 243, 536 2431, 536 2432, 536 2433, 435 72

Abstract:

Novel chiral compounds that mimic and/or modulate the activity of wild-type nucleic acids are disclosed. In general, the compounds are phosphorothioate oligonucleotides wherein the 5â, and the 3â-terminal internucleoside linkages are chirally Sp and internal internucleoside linkages are chirally Rp.

US Patent:

6639061, Oct 28, 2003

Filed:

Jul 7, 1999

Appl. No.:

09/349033

Inventors:

Phillip Dan Cook - Fallbrook CA
Muthiah Manoharan - Carlsbad CA
Martin Maier - Carlsbad CA
Haoyun An - Carlsbad CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07H 2102

US Classification:

536 231, 536 221, 536 2331, 536 253, 536 261, 536 271, 435 6, 435 911

Abstract:

The present invention is directed to nucleoside monomers wherein the 3â-O atom is replaced with a methylene group. The present invention also provides oligomers comprising a plurality of such monomers which are linked by methylene phosphonate linkages. Further, methods of preparing monomers and oligomers according to the present invention are provided.

US Patent:

6699979, Mar 2, 2004

Filed:

May 17, 2002

Appl. No.:

10/150696

Inventors:

Phillip Dan Cook - Fallbrook CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07H 1900

US Classification:

536 221, 536 281, 536 286, 536 253, 544 1, 544224, 544233

Abstract:

Sequence-specific oligonucleotides are provided having substantially pure chiral Sp phosphorothioate, chiral Rp phosphorothioate, chiral Sp alkylphosphonate, chiral Rp alkylphosphonate, chiral Sp phosphoamidate, chiral Rp phosphoamidate, chiral Sp phosphotriester, and chiral Rp phosphotriester linkages. The novel oligonucleotides are prepared via a stereospecific SN nucleophilic attack of a phosphodiester, phosphorothioate, phosphoramidate, phosphotriester or alkylphosphonate anion on the 3â position of a xylonucleotide. The reaction proceeds via inversion at the 3â position of the xylo reactant species, resulting in the incorporation of phosphodiester, phosphorothioate, phosphoramidate, phosphotriester or alkylphosphonate linked ribofuranosyl sugar moieties into the oligonucleotide.

US Patent:

6861514, Mar 1, 2005

Filed:

Oct 9, 2001

Appl. No.:

09/973981

Inventors:

Phillip Dan Cook - Fallbrook CA, US
Muthiah Manoharan - Carlsbad CA, US
Balkrishen Bhat - Carlsbad CA, US

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07H021/00
C07H021/02
C07H021/04
C07D237/00
A01K031/70

US Classification:

536 231, 536 243, 536 253, 536 2531, 536 2532, 536 271, 544224, 514 44, 514279

Abstract:

Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2′-, 3′-, 5′-, nucleobase and internucleotide linkage sites. The folate can be attached via the α- or γ-carboxylate, optionally through a linking group. Methods for the regiospecific synthesis of the conjugates are disclosed. Also disclosed are nucleosidic and non-nucleosidic linkers conjugated to folic acid and related folates.

US Patent:

6974865, Dec 13, 2005

Filed:

Dec 18, 2002

Appl. No.:

10/322242

Inventors:

Phillip Dan Cook - Fallbrook CA, US
Muthiah Manoharan - Carlsbad CA, US
Martin Maier - Carlsbad CA, US
Haoyun An - Carlsbad CA, US

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07H021/02
C07H021/04

US Classification:

536 231, 536 221, 536 245, 536 253, 536 2531, 536 2534, 536 256, 536 261, 435 87, 435 90, 435 911, 435 912, 435 915

Abstract:

The present invention is directed to nucleoside monomers wherein the 3′-O atom is replaced with a methylene group. The present invention also provides oligomers comprising a plurality of such monomers which are linked by methylene phosphonate linkages. Further, methods of preparing monomers and oligomers according to the present invention are provided.

US Patent:

RE39464, Jan 9, 2007

Filed:

Aug 24, 2004

Appl. No.:

10/925348

Inventors:

Phillip Dan Cook - Fallbrook CA, US
Muthiah Manoharan - Weston MA, US

Assignee:

ISIS Pharmaceuticals Inc. - Carlsbad CA

International Classification:

A61K 31/70
G01N 33/53

US Classification:

514 43, 536 221, 536 231, 536 243, 536 2431, 536 2432, 536 2433, 435 72

Abstract:

Novel chiral compounds that mimic and/or modulate the activity of wild-type nucleic acids are disclosed. In general, the compounds are phosphorothioate oligonucleotides wherein the 5′, and the 3′-terminal internucleoside linkages are chirally Sp and internal internucleoside linkages are chirally Rp.

US Patent:

7285658, Oct 23, 2007

Filed:

Feb 28, 2003

Appl. No.:

10/376654

Inventors:

Phillip D. Cook - Fallbrook CA, US
Guangyi Wang - Carlsbad CA, US
Thomas W. Bruice - Carlsbad CA, US
Nicholas A. Boyle - Encinitas CA, US
Janet M. Leeds - Encinitas CA, US
Jennifer L. Brooks - Encinitas CA, US
Marija Prhavc - Encinitas CA, US
Maria Eugenia Ariza - San Marcos CA, US
Patrick C. Fagan - Escondido CA, US
Yi Jin - Carlsbad CA, US
Vivek K. Rajwanshi - Vista CA, US
Kathleen D. Tucker - Escondido CA, US

Assignee:

Biota, Inc. - Carlsbad CA

International Classification:

A61K 31/7072
A61K 31/7076
C07H 19/167
C07H 19/173
C07H 19/19
C07H 19/20

US Classification:

536 262, 536 2622, 536 2626, 514 49, 514 51

Abstract:

The present invention relates to nucleoside diphosphate mimics and nucleoside triphosphate mimics, which contain diphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or base-modifications. The nucleotide mimics of the present invention, in a form of a pharmaceutically acceptable salt, a pharmaceutically acceptable prodrug, or a pharmaceutical formulation, are useful as antiviral, antimicrobial, and anticancer agents. The present invention provides a method for the treatment of viral infections, microbial infections, and proliferative disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of the present invention optionally in combination with other pharmaceutically active agents.