Philip Michael Stein

US Patent:

6511973, Jan 28, 2003

Filed:

Jul 27, 2001

Appl. No.:

09/916941

Inventors:

Philip D. Stein - Pennington NJ
Yan Shi - Flourtown PA
Stephen P. OConnor - Newtown PA
Chi Li - Randolph NJ

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

C07D22312

US Classification:

51421203, 51421208, 540524, 540527

Abstract:

Compound of the formula are inhibitors of the enzyme Factor Xa. These compounds are useful as anticoagulants in the treatment of cardiovascular diseases associated with thromboses.

US Patent:

6544981, Apr 8, 2003

Filed:

Jun 5, 2001

Appl. No.:

09/874739

Inventors:

Philip D. Stein - Pennington NJ
Stephen P. OConnor - Newtown PA
Yan Shi - Flourtown PA
Chi Li - Randolph NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D40512

US Classification:

51421208, 540526, 540527

Abstract:

Lactam inhibitors are provided which have the structure including pharmaceutically acceptable salts thereof and all stereoisomers thereof, and prodrug esters thereof, wherein n is 1 to 5; and and R , R , R , R , R , R , R , R , R , R , R , R and R are as defined herein. These compounds are inhibitors of Factor Xa and thus are useful as anticoagulants. A method for treating cardiovascular diseases associated with thromboses is also provided.

US Patent:

6555542, Apr 29, 2003

Filed:

Jan 29, 2002

Appl. No.:

10/059621

Inventors:

Stephen P. OConnor - Newtown PA
Michael Lawrence - Yardley PA
Yan Shi - Flourtown PA
Philip D. Stein - Pennington NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 314412

US Classification:

51425309, 514183, 514349, 514345, 514352, 514357, 514408, 514423, 514438, 514445, 514444, 546188, 546207, 546208, 546212, 546223, 546229, 546232, 548566, 548570, 549 74, 549 78, 549 62, 540485, 540596, 540605, 540609

Abstract:

Sulfonamide lactams of the following formula wherein X, R , R , R , R , R , R , R , R , R , R and R are as described herein, are provided which inhibitors of Factor Xa and are useful as anticoagulants in the treatment of cardiovascular diseases associated with thromboses.

US Patent:

6624309, Sep 23, 2003

Filed:

Sep 25, 2002

Appl. No.:

10/254398

Inventors:

John Lloyd - Yardley PA
George C. Rovnyak - Hopewell NJ
Philip D. Stein - Pennington NJ
Saleem Ahmad - Wall NJ
Karnail S. Atwal - Newtown PA
Thomas J. Caulfield - Lawrenceville NJ
Michael A. Poss - Lawrenceville NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 2706

US Classification:

548131, 548247, 548253, 5482676, 5483097, 5483381, 5483751, 548491, 546337, 544264, 544301, 514256, 514261, 514357, 514378, 514381, 514383, 514394, 514399, 514403, 514406, 514415, 514438

Abstract:

Benzoic acid derivatives of the formula where X is oxygen, sulfur, âNH, âNR , âNâCN, âNâOR or âNâNO ; Y is a single bond, âC Câ, or âNH; R is alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocyclo, or (heterocyclo)alkyl; and R is aryl or heterocyclo. The compounds of formula I are useful in the treatment of arrhythmia.

US Patent:

6673824, Jan 6, 2004

Filed:

Apr 19, 2000

Appl. No.:

09/552543

Inventors:

Natesan Murugesan - Lawrenceville NJ
John T. Hunt - Princeton NJ
Philip D. Stein - Princeton NJ

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

A61K 3142

US Classification:

514379, 514380

Abstract:

Compounds of the formula inhibit the activity of endothelin. The symbols are defined as follows: R , R and R are each independently (a) hydrogen, except that R is other than hydrogen; (b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z , Z and Z ; (c) halo; (d) hydroxyl; (e) cyano; (f) nitro; (g) âC(O)H or âC(O)R ; (h) âCO H or âCO R ; (i) âSH, âS(O) R , âS(O) âOH, âS(O) âOR , âOâS(O) âR , âOâS(O) OH or âOâS(O) âOR ; (j) âZ âNR R ; or (k) âZ âN(R )âZ âNR R ; and the remaining symbols are as defined in the specification.

US Patent:

6916813, Jul 12, 2005

Filed:

Dec 10, 2002

Appl. No.:

10/315818

Inventors:

Karnail S. Atwal - Pennington NJ, US
Gary J. Grover - Stockton NJ, US
Charles Z. Ding - Dallas TX, US
Philip D. Stein - Pennington NJ, US
John Lloyd - Yardley PA, US
Saleem Ahmad - Wall NJ, US
Lawrnce G. Hamann - Cherry Hill NJ, US
David Green - Haverhill MA, US
Francis N. Ferrara - Bedminster NJ, US

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

A01N043/50
A61K031/415

US Classification:

5142358, 51425401, 514314, 514357, 514361, 514374, 514383, 514394, 514397, 514399, 544139, 544370, 546164, 5462751, 548127, 548204, 5482628, 5483097, 5483147, 5483151, 5483154, 5483365

Abstract:

Compounds having the formula (I), and pharmaceutically acceptable salts thereof, are useful for modulating mitochondrial FFATPase activity and treating ischemic conditions including myocardial infarction, congestive heart failure, and cardiac arrhythmias.

US Patent:

7166586, Jan 23, 2007

Filed:

Feb 26, 2003

Appl. No.:

10/374299

Inventors:

Stephen P. O'Connor - Newtown PA, US
Michael Lawrence - Yardley PA, US
Yan Shi - Flourtown PA, US
Philip D. Stein - Pennington NJ, US

Assignee:

Bristol Myers Squibb Co. - Princeton NJ

International Classification:

C07D 41/02
A61K 31/454
A61K 31/445

US Classification:

514183, 514349, 514326, 546207, 546218

Abstract:

Sulfonamide lactams of the following formula.

US Patent:

7659281, Feb 9, 2010

Filed:

Apr 24, 2007

Appl. No.:

11/789335

Inventors:

Philip D. Stein - Pennington NJ, US
Steven P. Seitz - Swarthmore PA, US
David J. Carini - Wallingford CT, US
Yan Shi - Flourtown PA, US
Jeffrey A. Robl - Newtown PA, US
Jay A. Markwalder - New London PA, US
Chunhong He - Boothwyn PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A01N 43/42
A61K 31/44
C07D 221/18
C07D 221/22

US Classification:

514279, 546 26

Abstract:

Compounds are provided of the following structure are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperlipidemia and dyslipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis.

Author:

Philip L. Stein

ISBN #:

0070609853

Author:

Philip L. Stein

ISBN #:

0070609861

Author:

Philip L. Stein

ISBN #:

0070611165

Author:

Philip L. Stein

ISBN #:

0070611513

Author:

Philip L. Stein

ISBN #:

0070611653

Author:

Philip L. Stein

ISBN #:

0070612498

Author:

Philip L. Stein

ISBN #:

0070612528

Author:

Philip L. Stein

ISBN #:

0070614598

Address:

4218 Mdw Lark Dr, Calabasas, CA 91302

Phone:

818 222-5517

VIN:

1G6DW67V590130716

Make:

CADILLAC

Model:

STS

Year:

2009