Philip J Magistro

US Patent:

20110245287, Oct 6, 2011

Filed:

Feb 9, 2011

Appl. No.:

13/024298

Inventors:

John W. Holaday - Bethesda MD, US
Philip Magistro - Randolph NJ, US

International Classification:

A61K 31/4748
C07D 489/02
A61P 25/04

US Classification:

514282, 546 45

Abstract:

Disclosed are hybrid opioid compounds, mixed opioid salts, compositions comprising the hybrid opioid compounds and mixed opioid salts, and methods of use thereof. More particularly, in one aspect the hybrid opioid compound includes at least two opioid compounds that are covalently bonded to a linker moiety. In another aspect, the hybrid opioid compound relates to mixed opioid salts comprising at least two different opioid compounds or an opioid compound and a different active agent. Also disclosed are pharmaceutical compositions, as well as to methods of treating pain in humans using the hybrid compounds and mixed opioid salts.

US Patent:

20150165052, Jun 18, 2015

Filed:

May 10, 2013

Appl. No.:

13/891793

Inventors:

- North Sydney NSW, AU
Philip Magistro - Randolph NJ, US

International Classification:

A61K 47/48
A61K 31/485

Abstract:

Disclosed are hybrid opioid compounds, mixed opioid salts, compositions comprising the hybrid opioid compounds and mixed opioid salts, and methods of use thereof. More particularly, in one aspect the hybrid opioid compound includes at least two opioid compounds that are covalently bonded to a linker moiety. In another aspect, the hybrid opioid compound relates to mixed opioid salts comprising at least two different opioid compounds or an opioid compound and a different active agent. Also disclosed are pharmaceutical compositions, as well as to methods of treating pain in humans using the hybrid compounds and mixed opioid salts.