Philip V Lograsso from Tallahassee, FL, age 62

Us Patents

Use Of (Di-Substituted-Phenyl)-Pyrimidinyl-Imidazole Derivatives As Jnk-Inhibitors
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US Patent:

20020032183, Mar 14, 2002
Filed:

Sep 17, 2001
Appl. No.:

09/864949
Inventors:

Philip LoGrasso - Carlsbad CA, US
Steven Xanthoudakis - Beaconsfied, CA
John Tam - Montreal, CA
Sarah Harper - Bishop Stortford, GB
James Bilsland - Bishop's Storford Hertfordshire, GB
Lisa Young - Harlow, GB
International Classification:

A61K031/554
A61K031/553
A61K031/55
A61K031/5377
A61K031/541
A61K031/506
US Classification:

514/210200, 514/256000, 514/217060, 514/211150, 514/227800, 514/235800
Abstract:

A method of promoting neuronal survival and helping prevent neuronal death administers (di-substituted-phenyl) pyrimidinyl imidazole derivative compounds represented by effective to inhibit the activity of c-jun-N-terminal kinase.

Substituted Pyrimidinyl-Amines As Protein Kinase Inhibitors
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US Patent:

20100298312, Nov 25, 2010
Filed:

Sep 3, 2008
Appl. No.:

12/676411
Inventors:

Theodore M. Kamenecka - Palms Beach Gardens FL, US
Rong Jiang - Fuquay Varina NC, US
Xinyi Song - Jupiter FL, US
Philip LoGrasso - Jupiter FL, US
Michael D. Cameron - Port nSt. Lucie FL, US
Derek R. Duckett - Jupiter FL, US
Assignee:

The Scripps Research Institute - La Jolla CA
International Classification:

A61K 31/5377
C07D 403/12
C07D 239/42
C07D 413/14
C07D 403/14
C07D 401/14
A61K 31/506
A61K 31/497
A61P 35/00
A61P 25/16
A61P 3/10
A61P 9/10
A61P 25/28
A61P 25/00
A61P 11/00
A61P 29/00
A61P 31/00
A61P 37/02
A61P 9/00
US Classification:

5142322, 544331, 544332, 544122, 544295, 544121, 544330, 514275, 5142362, 5142358, 51425219, 51425218
Abstract:

The present invention provides novel substituted pyrimidinyl-amines that are useful as inhibitors of protein kinases, especially c-Jun N-terminal kinases (JNK) and pharmaceutical compositions thereof and methods of using the same for treating conditions responsive to the inhibition of the JNK pathway.

Anilides And Analogs As Rho Kinase Inhibitors
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US Patent:

20110038835, Feb 17, 2011
Filed:

Dec 18, 2008
Appl. No.:

12/808052
Inventors:

Yangbo Feng - Palm Beach Gardens FL, US
Philip LoGrasso - Jupiter FL, US
Thomas Bannister - Palm Beach Gardens FL, US
Thomas Schroeter - Riviera Beach FL, US
Xingang Fang - Riviera FL, US
Yen ting Chen - Palm Beach Gardens FL, US
Yan Yin - Jupiter FL, US
Michael P. Smolinski - Port St. Lucie FL, US
Lei Yao - Tianjin, CN
Bo Wang - Collegeville PA, US
Hampton Sessions - Orlando FL, US
Assignee:

The Scripps Research Institute - La Jolla CA
International Classification:

A61K 31/5377
C07D 231/12
A61K 31/415
C07D 471/02
A61K 31/437
C07D 487/04
A61K 31/519
C07D 401/12
A61K 31/4439
C07D 217/00
A61K 31/47
C07D 413/10
C07D 413/14
A61P 9/00
A61P 9/12
A61P 9/10
A61P 25/00
A61P 25/16
A61P 11/06
A61P 19/02
A61P 3/00
A61K 39/395
A61K 33/24
A61K 31/675
A61K 38/21
US Classification:

424 856, 5483771, 514406, 546113, 514300, 544280, 5142651, 546122, 5462754, 514341, 546146, 514307, 544140, 5142365, 544128, 5142352, 4241411, 424649, 514 79, 4241331
Abstract:

Compounds useful as Rho kinase inhibitors of formula (I): wherein variable are as defined herein are provided. Methods of treatment of malconditions mediated by Rho kinase, and methods of preparation of the compounds, are also provided.

Benzimidazoles And Analogs As Rho Kinase Inhibitors
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US Patent:

20110052562, Mar 3, 2011
Filed:

Dec 18, 2008
Appl. No.:

12/745357
Inventors:

Yangbo Feng - Palm Beach Gardens FL, US
Philip LoGrasso - Jupiter FL, US
Thomas Bannister - Palm Beach Gardens FL, US
Thomas Schroeter - Riviera Beach FL, US
Hampton Sessions - Orlando FL, US
Lei Yao - Tianjin, CN
Bo Wang - Collegeville PA, US
Michael P. Smolinski - Port St. Lucie FL, US
Yen Ting Chen - Palm Beach Gardens FL, US
Yan Yin - Jupiter FL, US
Bozena Frackowiak-Wojtasek - Dobrzen Wielki, PL
Sarwat Chowdhury - Palm Beach Gardens FL, US
Assignee:

The Scripps Research Institute - La Jolla CA
International Classification:

A61K 38/49
C07D 405/04
A61K 31/4184
A61P 9/10
A61P 9/12
A61P 25/28
A61P 25/16
A61P 11/06
A61P 19/02
A61P 19/10
A61P 17/06
A61P 27/06
A61P 3/10
A61P 13/00
A61P 31/12
C07D 405/14
A61K 31/4439
C07D 471/04
A61K 31/437
C07D 487/04
A61K 31/519
A61K 31/506
A61K 31/5377
C07D 413/14
US Classification:

424 9464, 5483051, 514394, 5462734, 514338, 546113, 514300, 544280, 5142651, 546122, 544279, 5142641, 544331, 514275, 5142345, 544124, 544122
Abstract:

Compounds useful as Rho kinase inhibitors according to formula IA or IB: wherein A, B, D, E, R, Rand Arare as defined herein, and any tautomer, salt, stereoisomer, hydrate, solvent, or prodrug thereof, pharmaceutical compositions, methods of treatment, and synthetic methods are provided.

Benzopyrans And Analogs As Rho Kinase Inhibitors
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US Patent:

20110150833, Jun 23, 2011
Filed:

Dec 18, 2008
Appl. No.:

12/746776
Inventors:

Yangbo Feng - Palm Beach Gardens FL, US
Philip LoGrasso - Jupiter FL, US
Thomas Bannister - Palm Beach Gardens FL, US
Thomas Schroeter - Riviera Beach FL, US
Yen Ting Chen - Palm Beach Gardens FL, US
Yan Yin - Jupiter FL, US
Hampton Sessions - Orlando FL, US
Michael P. Smolinski - Port St. Lucie FL, US
Lei Yao - Tianjin, CN
Bo Wang - Collegeville PA, US
Bozena Frackowiak-Wojtasek - Wielki, PL
Assignee:

The Scripps Research Institute - La Jolla CA
International Classification:

A61K 31/4155
C07D 405/12
A61K 31/4433
C07D 405/14
A61K 31/496
A61K 31/506
A61K 31/519
C07D 471/02
A61K 31/4375
A61K 31/501
A61K 38/21
A61K 39/395
A61K 31/56
A61P 9/00
A61P 15/10
A61P 29/00
A61P 25/00
A61P 19/02
A61P 11/00
A61P 35/00
A61P 31/04
US Classification:

424 856, 5483644, 514406, 5462824, 514338, 544364, 51425311, 544332, 514275, 544280, 5142651, 546122, 514300, 544238, 51425203, 4241331, 514171
Abstract:

Compounds useful as Rho kinase inhibitors of formula (1) wherein the variables are as defined herein are provided. Methods of treatment of malconditions mediated by Rho kinase, and methods of preparation of the compounds, are also provided.

Substituted Pyrimidinyl-Amines As Protein Kinase Inhibitors
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US Patent:

20130231336, Sep 5, 2013
Filed:

Feb 13, 2013
Appl. No.:

13/766075
Inventors:

Theodore Mark Kamenecka - Palm Beach Gardens FL, US
Rong Jiang - Fuquay Varina NC, US
Xinyi Song - Jupiter FL, US
Philip LoGrasso - Jupiter FL, US
Michael Darin Cameron - Port Saint Lucie FL, US
Derek R. Duckett - Jupiter FL, US
Assignee:

The Scripps Research Institute - La Jolla CA
International Classification:

C07D 239/42
C07D 403/14
C07D 413/12
C07D 403/12
C07D 401/14
US Classification:

5142322, 5142362, 51425218, 51425219, 514275
Abstract:

The present invention provides novel substituted pyrimidinyl-amines that are useful as inhibitors of protein kinases, especially c-Jun N-terminal kinases (JNK) and pharmaceutical compositions thereof and methods of using the same for treating conditions responsive to the inhibition of the JNK pathway.

Novel Compounds As Jnk Kinase Inhibitors
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US Patent:

20160304466, Oct 20, 2016
Filed:

Dec 3, 2014
Appl. No.:

15/101738
Inventors:

- La Jolla CA, US
Philip Lograsso - Jupiter FL, US
Ke Zheng - Palm Beach Gardens FL, US
Chul Min Park - Junggu, KR
International Classification:

C07D 231/40
C07D 401/14
C07D 409/14
C07D 403/12
C07D 239/47
C07D 405/12
C07D 417/12
C07D 417/14
C07D 471/04
C07D 487/04
C07D 401/12
C07D 403/14
Abstract:

The present invention is directed to modulators, such as inhibitors, of JNK isoform 2 (JNK2) or isoform 3 (JNK3) comprising compounds of formula (I) or formula (II) as described herein. Compounds of the invention can be used for treatment of a medical disorder in a patient wherein modulation of JNK3 is medically indicated, such as when the disorder is Parkinson disease (PD) Alzheimer's disease (AD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), myocardial infarction (MI), glaucoma, obesity, diabetes, cancer, rheumatoid arthritis, fibrotic disease, pulmonary fibrosis, kidney disease, liver inflammation, Crohns disease, hearing loss, Prader Willi syndrome, or a condition where modification of feeding behavior is medically indicated.

Substituted Pyrimidinyl-Amines As Protein Kinase Inhibitors
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US Patent:

20150232429, Aug 20, 2015
Filed:

Apr 27, 2015
Appl. No.:

14/696935
Inventors:

- La Jolla CA, US
Rong Jiang - Fuquay Varina NC, US
Xinyi Song - Jupiter FL, US
Philip LoGrasso - Jupiter FL, US
Michael Darin Cameron - Port Saint Lucie FL, US
Derek R. Duckett - Jupiter FL, US
International Classification:

C07D 239/42
C07D 413/12
C07D 403/14
C07D 401/14
C07D 491/113
C07D 403/12
Abstract:

The present invention provides novel substituted pyrimidinyl-amines that are useful as inhibitors of protein kinases, especially c-Jun N-terminal kinases (JNK) and pharmaceutical compositions thereof and methods of using the same for treating conditions responsive to the inhibition of the JNK pathway.

Name / Title

Company / Classification

Phones & Addresses

Philip Lograsso

Stem Cell Vet Therapy, LLC
Specialty Outpatient Clinic

777 S Flagler Dr, West Palm Beach, FL 33401

Philip Lograsso

MEALS ON WHEELS OF THE PALM BEACHES, INC

1300 S Olive Ave, West Palm Beach, FL 33401
West Palm Beach, FL 33402
118 Segovia Way, Jupiter, FL 33458

Philip Lograsso
Director

ABACOA PARTNERSHIP FOR COMMUNITY, INC
Social Services

Room Sr21 ROOM SR214, Jupiter, FL 33458
421 SW Camden Ave, Stuart, FL 34994
5353 Parkside Dr, Jupiter, FL 33458

Resumes

Professor, Molecular Therapeutics, And Sr. Direcetor Drug Discovery At The Scripps Research Institute

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Location:

West Palm Beach, Florida Area

Industry:

Biotechnology

Experience:

The Scripps Research Institute (Non-Profit; Research industry): Professor, Molecular Therapeutics, and Sr. Direcetor Drug Discovery, (July 2005-Present) Oversee group of 35 biologists and chemists working on drug discovery projects in CNS, metabolic disease, and ophthalmology.

Philip V Lograsso

Philip Lograsso Phones & Addresses

Interests

Industries

Us Patents

Use Of (Di-Substituted-Phenyl)-Pyrimidinyl-Imidazole Derivatives As Jnk-Inhibitors

Substituted Pyrimidinyl-Amines As Protein Kinase Inhibitors

Anilides And Analogs As Rho Kinase Inhibitors

Benzimidazoles And Analogs As Rho Kinase Inhibitors

Benzopyrans And Analogs As Rho Kinase Inhibitors

Substituted Pyrimidinyl-Amines As Protein Kinase Inhibitors

Novel Compounds As Jnk Kinase Inhibitors

Substituted Pyrimidinyl-Amines As Protein Kinase Inhibitors

Resumes

Professor, Molecular Therapeutics, And Sr. Direcetor Drug Discovery At The Scripps Research Institute

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Philip A. LoGrasso

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