Peyman Najmabadi

US Patent:

20110115897, May 19, 2011

Filed:

Oct 23, 2009

Appl. No.:

12/990576

Inventors:

Peyman Najmabadi - Vista CA, US
Gregory J. Crandall - Vista CA, US
Aaron Alan Stearrett - Vista CA, US
Dirk G. Soenksen - Vista CA, US
Christopher Adam Lee - Vista CA, US
Cynthia Perz - Vista CA, US

Assignee:

APERIO TECHNOLOGIES, INC. - Vista CA

International Classification:

H04N 7/18

US Classification:

348 79, 348E07085

Abstract:

A whole slide fluorescence digital pathology system is provided that uses a monochrome TDI line scan camera, which is particularly useful in fluorescence scanning where the signal is typically much weaker than in brightfield microscopy. The system uses oblique brightfield illumination for fast and accurate tissue finding and employs a unique double sweep focus scoring and objective lens height averaging technique to identify focus points and create a focus map that can be followed during subsequent scanning to provide autofocusing capability. The system also scans and analyzes image data to determine the optimal line rate for the TDI line scan camera to use during subsequent scanning of the digital slide image and it also creates a light profile to compensate for loss of illumination light due to roll off.

US Patent:

20220357565, Nov 10, 2022

Filed:

Jul 21, 2022

Appl. No.:

17/814180

Inventors:

- Vista CA, US
Allen OLSON - San Diego CA, US
Yunlu ZOU - San Diego CA, US
Peyman NAJMABADI - San Diego CA, US
Greg CRANDALL - San Marcos CA, US

International Classification:

G02B 21/24
G02B 21/00
G06T 7/50

Abstract:

Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.

US Patent:

20220283679, Sep 8, 2022

Filed:

Aug 6, 2020

Appl. No.:

17/631336

Inventors:

- Vista CA, US
Peyman NAJMABADI - Vista CA, US
Nicholas NEWBERG - Vista CA, US
Paul GEORGIEF - Vista CA, US
Lance MIKUS - Vista CA, US
Prentash DJELOSEVIC - Vista CA, US

International Classification:

G06F 3/0484
G01N 35/00
G01N 35/02
G06F 3/0488

Abstract:

Graphical user interface for managing a workflow of a slide scanning system. In an embodiment, the graphical user interface comprises a graphical representation of a carousel used by the scanning system. The graphical representation of the carousel comprises a graphical representation of each of a plurality of rack slots, configured to receive slide racks. The graphical representation of the carousel indicates a position of the carousel, and the graphical representation of each of the plurality of rack slots indicates a status of the represented rack slot and/or a slide rack within the represented rack slot.

US Patent:

20220196686, Jun 23, 2022

Filed:

Jan 10, 2022

Appl. No.:

17/572595

Inventors:

- Vista CA, US
Prentash Djelosevic - Oceanside CA, US
Aaron Stearrett - Port Orchard WA, US
Peyman Najmabadi - San Diego CA, US

International Classification:

G01N 35/00
G01V 8/12
G01N 21/84

Abstract:

A slide rack inventory and reinsertion system for use with a digital slide scanning apparatus is provided that determines, prior to scanning of glass slides in a slide rack, a status of each slot in the slide rack as properly occupied, improperly occupied, or empty. The system also determines whether a slide that has been removed from the slide rack for processing has been properly reinserted into the slide rack.

US Patent:

20210103134, Apr 8, 2021

Filed:

Nov 25, 2020

Appl. No.:

17/105251

Inventors:

- Vista CA, US
Allen OLSON - San Diego CA, US
Yunlu ZOU - San Diego CA, US
Peyman NAJMABADI - San Diego CA, US
Greg CRANDALL - San Marcos CA, US

International Classification:

G02B 21/24
G02B 21/00
G06T 7/50

Abstract:

Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.

US Patent:

20210055317, Feb 25, 2021

Filed:

Oct 23, 2020

Appl. No.:

17/079241

Inventors:

- Vista CA, US
Prentash DJELOSEVIC - Oceanside CA, US
Aaron STEARRETT - Port Orchard WA, US
Peyman NAJMABADI - San Diego CA, US

International Classification:

G01N 35/00
G01V 8/12
G01N 21/84

Abstract:

A slide rack inventory and reinsertion system for use with a digital slide scanning apparatus is provided that determines, prior to scanning of glass slides in a slide rack, a status of each slot in the slide rack as properly occupied, improperly occupied, or empty. The system also determines whether a slide that has been removed from the slide rack for processing has been properly reinserted into the slide rack.

US Patent:

20210048606, Feb 18, 2021

Filed:

Oct 30, 2020

Appl. No.:

17/085962

Inventors:

- Vista CA, US
Kiran SALIGRAMA - San Diego CA, US
Yunlu ZOU - San Diego CA, US
Peyman NAJMABADI - San Diego CA, US

International Classification:

G02B 7/38
G02B 21/02
G02B 21/26
G02B 7/09
G02B 21/36

Abstract:

A digital scanning apparatus is provided that includes imaging and focusing sensors and a processor to analyze the image data captured by the imaging and focusing sensors and adjust the focus of the scanning apparatus in real time during a scanning operation. The individual pixels of the imaging sensor are all in the same image plane with respect to the optical path of the digital scanning apparatus. The individual pixels of the focusing sensor are each in a different image plane with respect to the optical path, and one pixel of the focusing sensor is on the same image plane as the image sensor. The processor analyzes image data from the imaging sensor and the focusing sensor and determines a distance and direction to adjust the relative position of an objective lens and a stage of the digital scanning apparatus to achieve optimal focus during the scanning operation.

US Patent:

20200385218, Dec 10, 2020

Filed:

May 18, 2020

Appl. No.:

16/877289

Inventors:

- Vista CA, US
Prentash DJELOSEVIC - Oceanside CA, US
Aaron STEARRETT - Port Orchard WA, US
Peyman NAJMABADI - San Diego CA, US

International Classification:

B65G 43/00
G01V 8/12
G01N 35/00
G02B 21/00
G01N 21/64

Abstract:

A stuck slide determination system is provided that determines if a slide (e.g., glass slide), positioned on a scanning stage at the start of the scanning process, gets stuck and does not move along with the scanning stage after the scanning process commences. In an embodiment, the system includes a sensor having a transmitter and receiver that are relatively positioned to detect the presence of the stage or a slide or the absence of the stage or a slide. When the scanning stage begins to move at the start of the scanning process, a processor monitors a signal from the sensor and determines if the slide is improperly positioned after the scanning process has commenced. If the slide is improperly positioned, the processor stops movement of the scanning stage in order to protect the slide from damage.