A prosthetic joint in an embodiment has two load-bearing surfaces that are slidingly disposed relative to each other and define a region of frictional contact. The joint is thermally managed as heat is removed from the region during joint use by thermal conduction so that the surfaces are maintained approximately at or below specified temperatures. In other embodiments, heat flows preferentially through one member which includes one of the surfaces. Use of high thermal conductivity materials in conjunction with various joint designs affording thermally managed devices are provided in numerous embodiments.
Extended Life Prosthetic Joints Through Thermal Management
A prosthetic joint has two load-bearing surfaces that are slidingly disposed relative to each other and define a region of frictional contact. The joint is thermally managed as heat is removed from the region of frictional contact during joint use by thermal conduction so that the surfaces are maintained approximately at or below specified temperatures. Embodiments of femoral ball members and acetabular cup members to be used in thermally managed prosthetic hip joints are provided.
Production And Use Of Pre S Polypeptides Of Hepatitis B Virus
George Acs - Manhasset NY Judith K. Christman - Wyckoff NJ Peter Price - New York NY Wolf Offensperger - Bad Durrheim, DE Silke Wahl - Buehl, DE
Assignee:
Mt. Sinai School of Medicine of the City University of New York - New York NY
International Classification:
C12N 1563 C12N 1570
US Classification:
435320
Abstract:
In accordance with the present invention, recombinant plasmids are described which, when inserted into microbial hosts, direct the synthesis of proteins in which preS polypeptides found on the surface of human hepatitis B virus are fused to the enzyme. beta. -galactosidase. The recombinant plasmids are produced by inserting DNA sequences encoding the preS polypeptides into the lacZ gene, which codes for E. coli. beta. -galactosidase, carried by the plasmids. Large amounts of the preS-. beta. -galactosidase fusion proteins can be isolated from microbial cultures carrying the recombinant plasmids. Antigenic determinants of fusion protein so produced are recognized by antibodies to the preS determinants of native hepatitis B virus. The. beta. -galactosidase activity of such fusion protein is detected by a suitable chromogenic or fluorogenic substrate. PreS-. beta. -galactosidase fusion proteins so produced can be used in an enzyme-linked immunosorbent assay (ELISA) to diagnose the presence of hepatitis B virus infection.
A birdfeeder, in an embodiment, affords selective access to its contents. The embodiment includes an enclosure for storing food, a port disposed in the sidewall of the enclosure, and a conduit disposed in the port. The conduit provides communication between the contents of the birdfeeder through the port to an external location where birds may perch and feed. Both hanging and posted feeders as well as methods of selectively feeding birds are provided in a number of embodiments.
Metro Atlanta (Lawrenceville, GA)Director Operations Services at S1 Corporation Past: Dir. IT at Geac, Professional Services at Brock Control Systems, Mgr. Professional...