Peter L Haeberli from Princeton, NJ, age 56

Compositions For The Delivery Of Negatively Charged Molecules
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US Patent:

6395713, May 28, 2002
Filed:

Jul 21, 1998
Appl. No.:

09/120520
Inventors:

Leonid Beigelman - Longmont CO
Alex Karpeisky - Layfayette CO
Peter Haeberli - Berthoud CO
David Sweedler - Louisville CO
Mark Reynolds - Layfayette CO
Nilabh Chaudhary - Superior CO
John Min - Longmont CO
Assignee:

Ribozyme Pharmaceuticals, Inc. - Boulder CO
International Classification:

A01N 4304
US Classification:

514 44, 21 2, 424450, 424422, 424423, 424449, 554105, 564159, 564157, 564511, 4352402, 435172 B, 4351721, 560158, 560159, 560180, 560190
Abstract:

This invention features permeability enhancer molecules, and methods, to increase membrane permeability of negatively charged polymers thereby facilitating cellular uptake of such polymers.

Nucleic Acid Molecules With Novel Chemical Compositions Capable Of Modulating Gene Expression
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US Patent:

6673611, Jan 6, 2004
Filed:

May 25, 2001
Appl. No.:

09/866316
Inventors:

James Thompson - Lafayette CO
Leonid Beigelman - Longmont CO
James McSwiggen - Boulder CO
Alexander Karpeisky - Lafayette CO
Laurent Bellon - Frederick MD
Mark Reynolds - Pleasanton CA
Michael Zwick - Madison WI
Thale Jarvis - Boulder CO
Tod Woolf - Sudbury MA
Peter Haeberli - Berthoud CO
Assignee:

Sirna Therapeutics, Inc. - Boulder CO
International Classification:

C12Q 168
US Classification:

435455, 435 6, 435 911, 435366, 536 231, 536 245
Abstract:

This invention relates to novel chemically-modified nucleic acid molecules having specific formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.

Methods For Synthesizing Nucleosides, Nucleoside Derivatives And Non-Nucleoside Derivatives
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US Patent:

6686463, Feb 3, 2004
Filed:

Aug 31, 2001
Appl. No.:

09/944554
Inventors:

Leonid Beigelman - Longmont CO
Alexander Karpeisky - Lafayette CO
Vladmir Serebryany - Boulder CO
Peter Haeberli - Berthoud CO
David Sweedler - Louisville CO
Assignee:

Sirna Therapeutics, Inc. - Boulder CO
International Classification:

C07H 1916
US Classification:

536 271, 536 273, 536124, 536 261
Abstract:

The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2â-amino, 2â-N-phthaloyl, 2â-O-methyl, 2â-O-silyl, 2â-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside derivatives.

Conjugates And Compositions For Cellular Delivery
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US Patent:

7491805, Feb 17, 2009
Filed:

Feb 13, 2004
Appl. No.:

10/780447
Inventors:

Chandra Vargeese - Broomfield CO, US
Peter Haeberli - Berthoud CO, US
Weimin Wang - Superior CO, US
Tongqian Chen - Longmont CO, US
Assignee:

Sirna Therapeutics, Inc. - San Francisco CA
International Classification:

A61K 31/7008
A61K 31/7028
C07H 15/04
US Classification:

536 179, 514 25
Abstract:

This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including galactosamine and N-acetyl galactosamine derived conjugates of biologically active compounds, including antibodies, antivirals, chemotherapeutics, peptides, proteins, hormones, nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids, DNAzymes, allozymes, antisense, dsRNA, siNA, siRNA, triplex oligonucleotides, 2,5-A chimeras, decoys and aptamers.

Compositions For The Delivery Of Negatively Charged Molecules
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US Patent:

7553830, Jun 30, 2009
Filed:

Apr 14, 2005
Appl. No.:

10/966174
Inventors:

Leonid Beigelman - Longmont CO, US
Alexander Karpeisky - Layfayette CO, US
Peter Haeberli - Berthoud CO, US
David Sweedler - Louisville CO, US
Mark Reynolds - Pleasanton CA, US
Nilabh Chaudhary - Superior CO, US
John Min - Longmont CO, US
Assignee:

Sirna Therapeutics, Inc. - San Francisco CA
International Classification:

A61K 31/26
C07J 9/00
US Classification:

514182, 552506
Abstract:

This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAS, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.

Conjugates And Compositions For Cellular Delivery
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US Patent:

7833992, Nov 16, 2010
Filed:

Apr 30, 2003
Appl. No.:

10/427160
Inventors:

Chandra Vargeese - Broomfield CO, US
Peter Haeberli - Berthoud CO, US
Weimin Wang - Superior CO, US
Tongqian Chen - Longmont CO, US
Assignee:

Merck Sharpe & Dohme - Rahway NJ
International Classification:

A61K 31/6615
A61K 31/7115
A61K 31/713
C07F 9/09
C07F 9/165
C07H 21/02
A61K 31/711
US Classification:

514103, 514 44 R, 514 44 A, 536 245, 562 20, 568 10
Abstract:

This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including cholesterol derived conjugates of biologically active compounds, including antibodies, antivirals, chemotherapeutics, peptides, proteins, hormones, nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids, DNAzymes, allozymes, antisense, dsRNA, siNA, siRNA, triplex oligonucleotides, 2,5-A chimeras, decoys and aptamers.

Conjugates And Compositions For Cellular Delivery
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US Patent:

7964578, Jun 21, 2011
Filed:

Oct 16, 2008
Appl. No.:

12/253156
Inventors:

Chandra Vargeese - Schwenksville PA, US
Peter Haeberli - San Francisco CA, US
Weimin Wang - Churchville PA, US
Tongqian Chen - Irvine CA, US
Assignee:

Sirna Therapeutics, Inc. - Boulder CO
International Classification:

C12N 15/113
C07H 21/02
US Classification:

514 44R, 514 44 A, 536 241, 536 245
Abstract:

This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including cholesterol, folate, galactose, galactosamine, N-acetyl galactosamine, PEG, phospholipid, peptide and human serum albumin (HSA) derived conjugates of biologically active compounds, including antibodies, antivirals, chemotherapeutics, peptides, proteins, hormones, nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids, DNAzymes, allozymes, antisense, dsRNA, siNA, siRNA, triplex oligonucleotides, 2,5-A chimeras, decoys and aptamers.