Peter G Glavinos from Doylestown, PA, age 63

Permeable, Non-Irritating Prodrugs Of Nonsteroidal And Steroidal Agents
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US Patent:

56819641, Oct 28, 1997
Filed:

Oct 5, 1994
Appl. No.:

8/318160
Inventors:

Paul Ashton - Boston MA
Thomas J. Smith - Weston MA
Peter G. Glavinos - Doylestown PA
John D. Conklin - Lexington KY
Peter A. Crooks - Lexington KY
Robert M. Riggs - Birmingham AL
Tadeusz Cynkowski - Lexington KY
Grazyna Cynkowska - Lexington KY
Assignee:

University of Kentucky Research Foundation - Lexington KY
International Classification:

C07D20942
C07J 500
US Classification:

548491
Abstract:

Prodrugs containing an active drug molecule linked to a polyethylene glycol group, and a method of use thereof are described. Exemplary soluble ester prodrugs contain naproxen, triamcinolone acetonide, gancyclovir, taxol, cyclosporin, dideoxyinosine, trihydroxy steroids, and flurbiprofen molecules linked to polyethylene glycol (PEG) groups. Pharmaceutical compositions containing these prodrugs, and a method of using these esters for treating disease states or symptoms are also described.