Peter H Dorff

US Patent:

20030191279, Oct 9, 2003

Filed:

Feb 20, 2003

Appl. No.:

10/371343

Inventors:

Steven Goldstein - Noank CT, US
John Lowe - Stonington CT, US
Kelly Longo - Mystic CT, US
Mohamed Mohamed Awad - Westerly RI, US
Chakrapani Subramanyam - South Glastonbury CT, US
Peter Dorff - Norwich CT, US

International Classification:

C07K005/04
C07D413/02
C 07D 4 3/02

US Classification:

530/331000, 544/331000

Abstract:

The present invention relates to compounds of formula I And to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R, R, R, R, R, R, R, b, m, n, p and v are as defined herein. The invention also relates to pharmaceutical compositions containing the above compounds and methods of treating hyperproliferative disorders in mammals by administering the above compounds.

US Patent:

20070270438, Nov 22, 2007

Filed:

May 9, 2007

Appl. No.:

11/746314

Inventors:

Samit Bhattacharya - Groton CT, US
Matthew Brown - Stonington CT, US
Peter Dorff - Griswold CT, US
Susan LaGreca - Old Lyme CT, US
Robert Maguire - East Lyme CT, US

International Classification:

A61K 31/497
A61K 31/4439
A61K 31/4245
C07D 413/02

US Classification:

514255050, 514341000, 514364000, 544405000, 546269100, 548131000

Abstract:

The invention relates to compounds of formula I and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof; wherein B, D, E, R, R, R, R, R, R, m, n, p, q, r, s, t and u are as defined herein. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

US Patent:

20090227641, Sep 10, 2009

Filed:

Nov 7, 2008

Appl. No.:

12/266997

Inventors:

Samit K. Bhattacharya - Groton CT, US
Matthew F. Brown - Stonington CT, US
Peter H. Dorff - Griswold CT, US
Susan D. LaGreca - Old Lyme CT, US
John W. Mickelson - Lakeville MN, US
Joseph A. Cornicelli - Ann Arbor MI, US
David L. Brown - Chesterfield MO, US
Rex Jennings - Voluntown CT, US
John K. Walker - Weldon Springs MO, US
Rita Huff - Wildwood MO, US
Joseph W. Strohbach - Wentzville MO, US
Robert J. Maguire - East Lyme CT, US

International Classification:

A61K 31/4245
C07D 271/06
A61P 19/02
A61P 35/00

US Classification:

514364, 548131

Abstract:

The invention relates to compounds of formula Iand to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

US Patent:

20090239865, Sep 24, 2009

Filed:

Nov 21, 2005

Appl. No.:

11/719885

Inventors:

George Chang - Old Saybrook CT, US
Mary Didiuk - Madison CT, US
Peter Dorff - Griswold CT, US
Ravi Garigipati - South Glastonbury CT, US
Wenhua Jiao - Salem CT, US
Bruce Lefker - Gales Ferry CT, US
David Perry - Mystic CT, US
Roger Ruggeri - Waterford CT, US
Toby Underwood - Kent, GB

International Classification:

A61K 31/5377
C07D 257/06
A61K 31/41
A61K 31/4439
C07D 401/14
C07D 413/14
A61P 9/10

US Classification:

5142362, 548251, 514381, 514340, 5462684, 544140

Abstract:

Dibenzyl amine compounds and derivatives, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

US Patent:

20100120794, May 13, 2010

Filed:

Jan 4, 2010

Appl. No.:

12/651885

Inventors:

Samit Kumar Bhattacharya - Groton CT, US
Matthew Frank Brown - Stonington CT, US
Peter Hans Dorff - Griswold CT, US
Susan LaGreca - Old Lyme CT, US

International Classification:

A61K 31/497
C07D 413/04
A61K 31/4439
C07D 417/04
A61P 37/00
A61P 19/02
A61P 3/10
A61P 1/00
A61P 29/00
A61P 11/06
A61P 9/10
A61K 31/506
C07D 271/06
A61K 31/4245
A61K 31/4436

US Classification:

51425505, 544405, 5462694, 514340, 5462704, 544333, 514256, 548131, 514364, 514342

Abstract:

The invention relates to compounds of formula Iand to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof; wherein B, D, E, R, R, R, R, R, R, m, n, p, q, r, s, t and u are as defined herein. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

US Patent:

20100234435, Sep 16, 2010

Filed:

May 13, 2010

Appl. No.:

12/779379

Inventors:

Samit K. Bhattacharya - Niantic CT, US
Matthew F. Brown - Stonington CT, US
Peter H. Dorff - Griswold CT, US
Susan D. LaGreca - Old Lyme CT, US
John W. Mickelson - Lakeville MN, US
Joseph A. Cornicelli - Ann Arbor MI, US
David L. Brown - Chesterfield MO, US
Jennings Rex - Voluntown CT, US
John K. Walker - Weldon Springs MO, US
Rita Huff - Wildwood MO, US
Joseph W. Strohbach - Wentzville MO, US
Robert J. Maguire - East Lyme CT, US

International Classification:

A61K 31/4245
C07D 271/06
A61P 19/02
C07D 405/14
C07D 401/04

US Classification:

514364, 548131, 544333, 5462684

Abstract:

The invention relates to compounds of formula Iand to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

US Patent:

60203358, Feb 1, 2000

Filed:

Nov 4, 1997

Appl. No.:

8/963852

Inventors:

Arthur A. Nagel - Gales Ferry CT
Steven W. Goldstein - Noank CT
Stanley Jung - Groton CT
Peter H. Dorff - Norwich CT

Assignee:

Pfizer Inc - New York NY

International Classification:

C07D21362
C07D21344
C07D21379
C07D21336

US Classification:

514253

Abstract:

An (N-(pyridinylmethyl)-heterocyclic)ylideneamine compound of the formula ##STR1## wherein R. sup. 3, A, and B are as described below, and its pharmaceutically acceptable salts and prodrugs. Compounds of the formula I and their pharmaceutically acceptable salts and prodrugs are useful in the treatment of addictive disorders, such as the use of tobacco or other nicotine containing products, neurological and mental disorders such as senile dementia of the Alzheimer's type, Parkinson's disease, attentional hyperactivity disorder, anxiety, obesity, Tourette's Syndrome and ulcerative colitis.

US Patent:

59197951, Jul 6, 1999

Filed:

Nov 28, 1997

Appl. No.:

8/952507

Inventors:

George Chang - Ivoryton CT
Peter H. Dorff - Norwich CT
George J. Quallich - North Stonington CT

Assignee:

Pfizer INc. - New York NY

International Classification:

C07D21704
C07D40106
A61K 3147
A61K 31495

US Classification:

514310

Abstract:

Compounds of formula (I), ##STR1## wherin X is CH. sub. 2, CO, CS or SO. sub. 2 ; Y is selected from: a direct link, aliphatic hydrocarbylene radicals having up to 20 carbon atoms, which radical may be mono-substituted by hydroxy, (C. sub. 1 -C. sub. 10)alkoxy, (C. sub. 1 -C. sub. 10)acyl, (C. sub. 1 -C. sub. 10)acyloxy, or (C. sub. 6 -C. sub. 10)aryl, NH, and O, provided that if X is CH. sub. 2,Y is a direct link; Z is selected from the following groups: (1) H, halo, cyano, (2) hydroxy, (C. sub. 1 -C. sub. 10)alkoxy, (C. sub. 1 -C. sub. 10)a1kylthio, (C. sub. 1 -C. sub. 10)acyl, thiophenylcaronyl (C. sub. 1 -C. sub. 10)alkoxycarbonyl, (3) (C. sub. 1 -C. sub. 10)aklkyammo, di(C. sub. 1 -C. sub. 10)alylamino, (C. sub. 6 -C. sub. 10)aryl(C. sub. 1 -C. sub. 10)alkylamino, provided that Y is not O or NH, (4) unsubstituted vinyl, (C. sub. 6 -C. sub.