Pearl S Huang

US Patent:

20070015154, Jan 18, 2007

Filed:

Feb 13, 2004

Appl. No.:

10/544704

Inventors:

Priti Hedge - Collegeville PA, US
Pearl Huang - Collegeville PA, US
Jeffrey Jackson - Collegeville PA, US

Assignee:

SMITHKLINE BEECHAM CORPORATION - Philidelphia PA

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

Nucleic acids that differentially expressed in certain tumors are provided. A variety of classification, screening, diagnostic and treatment methods are provided based upon these differentially expressed nucleic acids. Devices and kits for performing such methods are also disclosed.

US Patent:

20100280987, Nov 4, 2010

Filed:

Apr 16, 2010

Appl. No.:

12/761772

Inventors:

Andrey Loboda - Philadelphia PA, US
Theresa Zhang - Wellesley MA, US
James W. Watters - Chalfont PA, US
Pearl S. Huang - Lansdale PA, US
Michael Chastain - Glenside PA, US
Richard A. Klinghoffer - Seattle WA, US

International Classification:

G06N 5/02
G06F 19/00

US Classification:

706 54, 702 19

Abstract:

Methods, biomarkers, and expression signatures are disclosed for assessing the regulation status of RAS pathway signaling in a cell sample or subject. More specifically, several aspects of the invention provide a set of genes which can be used as biomarkers and gene signatures for evaluating RAS pathway deregulation status in a sample; classifying a cell sample as having a deregulated or regulated RAS signaling pathway; determining whether an agent modulates the RAS signaling pathway in sample; predicting response of a subject to an agent that modulates the RAS signaling pathway; assigning treatment to a subject; and evaluating the pharmacodynamic effects of cancer therapies designed to regulate RAS pathway signaling.