Pawel Witold Drapala

US Patent:

20140065226, Mar 6, 2014

Filed:

Mar 5, 2012

Appl. No.:

13/261732

Inventors:

Eric Brey - Chicago IL, US
Victor Perez-Luna - Naperville IL, US
Bin Jiang - Chicago IL, US
Pawel Drapala - Chicago IL, US
Rolf Schäfer - Arisdorf, CH
Hans Hitz - Arisdorf, CH

International Classification:

A61K 47/32
A61K 31/573

US Classification:

424490, 5147724, 514179

Abstract:

A thermo-responsive hydrogel, including a biocompatible monomer and/or polymer having a side chain-linked amino acid. The hydrogel is thermo-responsive at a physiological temperature, and can include, incorporate, or encapsulate a treatment agent, such as a drug composition, a biomolecule, and/or a nano-particle. The hydrogel is useful in delivering the treatment agent. The hydrogel is in a first physicochemical state for administration to a mammal. The hydrogel is thermo-responsive at a physiological temperature of the mammal, and changes to a second physicochemical state that is more solid than the first physicochemical state. In the second physicochemical state the thermo-responsive hydrogel releases the treatment agent.

US Patent:

20120231072, Sep 13, 2012

Filed:

Mar 11, 2011

Appl. No.:

13/045643

Inventors:

Eric BREY - Chicago IL, US
Victor PEREZ-LUNA - Naperville IL, US
Bin JIANG - Chicago IL, US
Pawel DRAPALA - Chicago IL, US
Hans Hitz - Arisdorf, CH
Rolf Schaefer - Arisdorf, CH

Assignee:

Chemisches Institut Schaefer AG - Bubendorf
Illinois Institute of Technology - Chicago IL

International Classification:

A61K 47/30
A61K 47/32
A61K 31/573
A61P 17/02
A61P 27/02
A61K 47/18
A61K 9/48
B82Y 5/00

US Classification:

424451, 514784, 5147726, 514180, 5147724, 5147721, 977915

Abstract:

A thermo-responsive hydrogel, including a biocompatible monomer and/or polymer having an amino acid side chain. The hydrogel is thermo-responsive at a physiological temperature, and can include, incorporate, or encapsulate a treatment agent, such as a drug composition, a biomolecule, and/or a nanoparticle. The hydrogel is useful in delivering the treatment agent. The hydrogel is in a first physicochemical state for administration to a mammal. The hydrogel is thermo-responsive at a physiological temperature of the mammal, and changes to a second physicochemical state that is more solid than the first physicochemical state. In the second physicochemical state the thermo-responsive hydrogel releases the treatment agent.