Paul M Will

Author:

Paul J. Will

ISBN #:

0891304029

US Patent:

20030176436, Sep 18, 2003

Filed:

Jun 28, 2002

Appl. No.:

10/184855

Inventors:

Paul Ala - Newark, DE
Janid Ali - Waltham MA, US
Jacob Clement - Vancouver, CA
Carlos Faerman - Acton MA, US
John Gazzaniga - Worcester MA, US
Andrew Magee - Maynard MA, US
Salvatore Marchese - Malden MA, US
Scott Moe - Marlborough MA, US
Manuel Navia - Lexington MA, US
Emanuele Perola - Cambridge MA, US
Paul Will - Stoneham MA, US

International Classification:

A61K031/525
A61K031/519
C07D475/08
C07D487/02

US Classification:

514/251000, 514/264100, 514/264110, 544/260000, 544/279000

Abstract:

This invention relates to novel heterocyclic compounds and to their use in the medical treatment or prophylaxis of bacterial infections, or their use as antiseptics, sterilizants, or disinfectants.

US Patent:

20070197619, Aug 23, 2007

Filed:

Mar 7, 2005

Appl. No.:

10/592283

Inventors:

Robert Zelle - Stow MA, US
Paul Will - Sudbury MA, US

International Classification:

A61K 31/4178
A61K 31/4172
C07D 403/02
C07D 233/28

US Classification:

514396000, 514397000, 548311100, 548334100

Abstract:

The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

US Patent:

20070203194, Aug 30, 2007

Filed:

Mar 7, 2005

Appl. No.:

10/592270

Inventors:

Robert Zelle - Stow MA, US
Vincent Galullo - South Grafton MA, US
Christopher Baker - Bedford MA, US
Paul Will - Sudbury MA, US
William Frazee - Belmont MA, US

Assignee:

SCION PHARMACEUTICALS, INC. - MEDFORD MA
WYETH - MADISON NJ

International Classification:

A61K 31/4196
A61K 31/435

US Classification:

514338000, 514384000

Abstract:

The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein cab be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

US Patent:

20070208064, Sep 6, 2007

Filed:

Mar 7, 2005

Appl. No.:

10/592203

Inventors:

Robert Zelle - Stow MA, US
Vincent Galullo - South Grafton MA, US
Paul Will - Sudbury MA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/428
A61K 31/427
A61K 31/423
A61K 31/422
A61K 31/4184
A61K 31/4178
C07D 417/02
C07D 403/02
C07D 413/02

US Classification:

514365000, 514397000, 514398000, 548311100, 548316400, 514374000, 514394000, 514367000, 514375000, 548152000, 548217000, 548203000, 548215000, 548305400

Abstract:

The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

US Patent:

20070281937, Dec 6, 2007

Filed:

Mar 7, 2005

Appl. No.:

10/592451

Inventors:

Robert Zelle - Stow MA, US
Vincent Galullo - South Grafton MA, US
Christopher Baker - Bedford MA, US
Paul Will - Sudbury MA, US
William Frazee - Madison WI, US
Hormoz Mazdiyasni - Marlborough MA, US
Jinsong Guo - Malden MA, US

International Classification:

A61K 31/4184
A61K 31/4164
A61K 31/4196
A61K 31/4245
A61K 31/428
A61K 31/4439
A61K 31/454
A61K 31/4709
A61K 31/5377
A61P 9/12
A61P 9/10
A61P 9/00
A61P 25/00
A61P 13/00
A61K 31/497
A61K 31/47
A61K 31/444
A61K 31/433
A61K 31/426
A61K 31/42
A61K 31/4178

US Classification:

514235800, 514254050, 514307000, 514314000, 514326000, 514333000, 514338000, 514341000, 514363000, 514364000, 514365000, 514367000, 514378000, 514383000, 514384000, 514395000, 514398000

Abstract:

The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

US Patent:

20080090847, Apr 17, 2008

Filed:

Dec 5, 2007

Appl. No.:

11/951214

Inventors:

Scott Moe - Marlborough MA, US
Paul Ala - Newark DE, US
Emanuele Perola - Cambridge MA, US
Carlos Faerman - Acton MA, US
Jacob Clement - Vancouver, CA
Janid Ali - Waltham MA, US
Paul Will - Stoneham MA, US
Salvatore Marchese - Malden MA, US
Andrew Magee - Maynard MA, US
John Gazzaniga - Worcester MA, US
Christopher Faraday - San Francisco CA, US
Manuel Navia - Lexington MA, US
Patrick Connelly - Harvard MA, US

Assignee:

PLIVA D.D. - Zagreb

International Classification:

A61K 31/495
A61P 33/00
C07D 475/04
C12N 9/99

US Classification:

514262100, 435184000, 544260000

Abstract:

The invention is based on the discovery of a new class of heterocyclic compounds having, for example, antibacterial properties. The D-Ala-D-Ala ligase enzyme is a critical pathway enzyme in the bacterial cell-wall synthesis. The compounds can bind to and inhibit the enzyme D-Ala-D-Ala ligase. The new compounds' activity combined with their ability to cross bacterial cell membranes makes them suitable for use as antibacterial drugs or other antibacterial applications.

US Patent:

20080293722, Nov 27, 2008

Filed:

Mar 15, 2005

Appl. No.:

10/592893

Inventors:

Robert Zelle - Stow MA, US
Christopher Todd Baker - Bedford MA, US
Paul Will - Sudbury MA, US
Vincent P. Galullo - South Grafton MA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/155
A61P 9/00
A61P 11/00
A61P 25/00
C07C 257/14
C07D 295/14
C07D 307/22
A61K 31/495
C07D 211/26
C07D 213/58
A61K 31/5375
A61K 31/4453
A61K 31/341
A61K 31/44

US Classification:

5142385, 51425212, 564246, 544165, 544336, 544402, 546231, 546332, 549491, 514331, 514471, 514357, 514637

Abstract:

The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

US Patent:

20100267697, Oct 21, 2010

Filed:

Dec 11, 2007

Appl. No.:

12/518342

Inventors:

Vincent P. Galullo - South Grafton MA, US
Robert Zelle - Stow MA, US
Danielle Soenen - Irvine CA, US
Christopher Todd Baker - Bedford MA, US
Paul Will - Sudbury MA, US
Hormoz Mazdiyasni - Marlborough MA, US
Jinsong Guo - Beijing, CN
Andrew Fensome - Wayne PA, US
Jeffrey Curtis Kern - Gilbertsville PA, US
William Jay Moore - Collegeville PA, US
Edward George Melenski - Collegeville PA, US
Justin Kaplan - Philadelphia PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/5513
A61K 31/55
A61K 31/54
A61K 31/535
A61K 31/5355
A61K 31/4995
A61K 31/501
A61K 31/497
A61K 31/506
A61K 31/44
A61K 31/4725
A61K 31/426
A61K 31/4709
A61K 31/4458
A61K 31/4453
A61K 31/4402
A61K 31/445
A61K 31/166
C07D 403/04
C07D 401/04
C07D 413/04
C07D 417/04
C07D 413/12
C07D 403/12
C07D 241/36
C07D 497/10
C07D 217/00
C07D 215/00
C07D 401/12
C07D 211/98
C07D 213/04
C07D 405/12
C07D 213/73
C07D 277/593
C07C 233/42

US Classification:

51421704, 514218, 5142278, 5142368, 5142372, 514249, 51425203, 51425301, 5142531, 514275, 514278, 514307, 514370, 514314, 514318, 514326, 514329, 514332, 514336, 514352, 514629, 540480, 540597, 540598, 544 60, 544131, 544133, 544238, 544331, 544349, 544360, 544369, 546 19, 546146, 546164, 546167, 546194, 546208, 546209, 546244, 546265, 5462834, 546311, 548194, 564220

Abstract:

The present teachings provide compounds of Formula (I)and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R, R, R, p, and X are defined herein. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.