Paul G Warrener

US Patent:

8173363, May 8, 2012

Filed:

Aug 20, 2003

Appl. No.:

10/525062

Inventors:

Kim Folger Bruce - Seattle WA, US
Paul Warrener - Seattle WA, US
Jennifer McLarnan - Everett WA, US
Kevin Hou - Issaquah WA, US

Assignee:

Novartis Vaccines and Diagnostics, Inc. - Emeryville CA

International Classification:

C12Q 1/68
C07H 21/04
G01N 33/48

US Classification:

435 6, 536 231, 536 241, 702 19, 702 20

Abstract:

The invention provides a method for generating a database of candidate essential genes in , as well as otherwise important genes that, when mutated, lead to a growth attenuated phenotype. Such genes and mutants of such genes are important for identifying antibacterial agents suitable for treating and preventing infections. The invention includes methods for confirming the essentiality or importance of candidate genes, as well as methods for utilizing those genes to screen for new antibacterial drugs. The invention also includes the antibacterial agents identified using the disclosed methods, as well as methods of using the same for treating and preventing infection.

US Patent:

8394614, Mar 12, 2013

Filed:

Jun 4, 2010

Appl. No.:

12/794536

Inventors:

James Roberts - Seattle WA, US
Fred Cross - Seattle WA, US
Paul Warrener - Seattle WA, US
Ernesto Javier Munoz - Seattle WA, US
Martin Henry Lee - Seattle WA, US
Khadidja Romari - Seattle WA, US
Kimberly Marie Kotovic - Seattle WA, US
Jason W. Hickman - Seattle WA, US

Assignee:

Matrix Genetics, LLC - Seattle WA

International Classification:

C12P 5/00
C12P 1/04
C12N 1/22

US Classification:

435170, 435 41, 435243, 4352521

Abstract:

This disclosure describes genetically modified photosynthetic microorganisms, including Cyanobacteria, that contain one or more exogenous genes encoding a diacylglycerol acyltransferase, a phosphatidate phosphatase, and/or an acetyl-CoA carboxylase, and which are capable of producing increased amounts of fatty acids and/or synthesizing triglycerides.

US Patent:

8394621, Mar 12, 2013

Filed:

Oct 23, 2009

Appl. No.:

12/605204

Inventors:

James Roberts - Seattle WA, US
Fred Cross - Seattle WA, US
Paul Warrener - Seattle WA, US
Ernesto Javier Munoz - Seattle WA, US
Martin Henry Lee - Seattle WA, US
Khadidja Romari - Seattle WA, US
Kimberly Marie Kotovic - Seattle WA, US
Jason W. Hickman - Seattle WA, US

Assignee:

Matrix Genetrics, LLC - Seattle WA

International Classification:

C12P 5/00
C12P 1/04
C12N 1/22

US Classification:

4352521, 435 41, 435170, 435243

Abstract:

This disclosure describes genetically modified photosynthetic microorganisms, including Cyanobacteria, that contain one or more exogenous genes encoding a diacylglycerol acyltransferase, a phosphatidate phosphatase, and/or an acetyl-CoA carboxylase, and which are capable of producing increased amounts of fatty acids and/or synthesizing triglycerides.

US Patent:

20070196829, Aug 23, 2007

Filed:

Oct 11, 2005

Appl. No.:

11/246458

Inventors:

Kim Bruce - Seattle WA, US
Paul Warrener - Seattle WA, US
Kevin Hou - Issaquah WA, US

Assignee:

CHIRON CORPORATION - Emeryville CA

International Classification:

C12Q 1/68
C12Q 1/18

US Classification:

435006000, 435032000

Abstract:

The invention includes a database of candidate essential genes in , as well as other important genes that, when mutated, lead to a growth attenuated phenotype. Such genes and mutants of such genes are important for identifying antibacterial agents suitable for treating and preventing infections. The invention includes methods for confirming the essentiality or importance of candidate genes, as well as methods for utilizing those genes to screen for new antibacterial drugs. The invention also includes the antibacterial agents identified using the disclosed methods, as well as methods of using the same for treating and preventing infection.

US Patent:

20100184169, Jul 22, 2010

Filed:

Dec 22, 2009

Appl. No.:

12/645228

Inventors:

James Roberts - Seattle WA, US
Fred Cross - Seattle WA, US
Paul Warrener - Seattle WA, US
Kimberly Marie Kotovic - Seattle WA, US
Margaret Mary McCormick - Seattle WA, US

Assignee:

TARGETED GROWTH, INC. - Seattle WA

International Classification:

C12P 7/64
C12N 1/21
C12P 1/04

US Classification:

435134, 4352523, 435170

Abstract:

This disclosure describes genetically modified photosynthetic microorganisms, including Cyanobacteria, that contain one or more mutations or deletions in a glycogen biosynthesis or storage pathway, which accumulate a reduced amount of glycogen as compared to a wild type , and which are capable of producing an increased amount of lipids and/or fatty acids. In certain embodiments, the genetically modified photosynthetic microorganisms also contain one or more exogenous genes encoding a diacyglycerol acyltransferase, a phosphatidate phosphatase, and/or an acetyl-CoA carboxylase, and which are capable of producing increased amounts of lipids or fatty acids and/or synthesizing triglycerides.

US Patent:

20110250659, Oct 13, 2011

Filed:

Apr 5, 2011

Appl. No.:

13/080496

Inventors:

James Roberts - Seattle WA, US
Fred Cross - Seattle WA, US
Paul Warrener - Seattle WA, US
Ernesto Javier Munoz - Seatte WA, US
Jason W. Hickman - Seattle WA, US

Assignee:

TARGETED GROWTH, INC. - Seattle WA

International Classification:

C12P 7/64
C12N 15/74
C12N 1/13

US Classification:

435134, 4352572, 435471

Abstract:

This disclosure describes genetically modified photosynthetic microorganisms, e.g., Cyanobacteria, that contain one or more exogenous genes encoding a phospholipase and/or thioesterase, which are capable of producing an increased amount of lipids and/or fatty acids. This disclosure also describes genetically modified photosynthetic microorganisms that contain one or more exogenous genes encoding a diacyglycerol acyltransferase, a phosphatidate phosphatase, and/or an acetyl-CoA carboxylase, which are capable of producing increased amounts of fatty acids and/or synthesizing triglycerides, as well as photosynthetic microorganism comprising mutations or deletions in a glycogen biosynthesis or storage pathway, which accumulate a reduced amount of glycogen under reduced nitrogen conditions as compared to a wild type photosynthetic microorganism.

US Patent:

20130143284, Jun 6, 2013

Filed:

Feb 6, 2013

Appl. No.:

13/761025

Inventors:

MATRIX GENETICS, LLC - Seattle WA, US
Fred Cross - Seattle WA, US
Paul Warrener - Seattle WA, US
Ernesto Javier Munoz - Seattle WA, US
Martin Henry Lee - Seattle WA, US
Khadidja Romari - Seattle WA, US
Kimberly Marie Kotovic - Seattle WA, US
Jason W. Hickman - Seattle WA, US

Assignee:

MATRIX GENETICS, LLC - Seattle WA

International Classification:

C12N 15/79

US Classification:

435134, 4352572, 435477

Abstract:

This disclosure describes genetically modified photosynthetic microorganisms, including Cyanobacteria, that contain one or more exogenous genes encoding a diacyglycerol acyltransferase, a phosphatidate phosphatase, and/or an acetyl-CoA carboxylase, and which are capable of producing increased amounts of fatty acids and/or synthesizing triglycerides.

US Patent:

20220177554, Jun 9, 2022

Filed:

Nov 15, 2021

Appl. No.:

17/454837

Inventors:

- Cambridge, GB
Paul WARRENER - Gaithersburg MD, US
Charles STOVER - Gaithersburg MD, US
Bret SELLMAN - Gaithersburg MD, US
Ralph MINTER - Cambrige, GB
Sandrine GUILLARD - Cambridge, GB
Steven RUST - Cambridge, GB
Mladen TOMICH - Exton PA, US
Vignesh VENKATRAMAN - Cambridge, GB
Reena VARKEY - Gaithersburg MD, US
Li PENG - Gaithersburg MD, US
Melissa DAMSCHRODER - Gaithersburg MD, US
Partha S. CHOWDHURY - Gaithersburg MD, US
Nazzareno DIMASI - Gaithersburg MD, US
Ryan FLEMING - Gaithersburg MD, US
Binyam BEZABEH - Gaithersburg MD, US
Changshou GAO - Gaithersburg MD, US
Godfrey RAINEY - Gaithersburg MD, US
Cuihua GAO - Gaithersburg MD, US

International Classification:

C07K 16/12

Abstract:

This disclosure relates to combination therapies comprising anti-Psl and PcrV binding molecules and related compositions, for use in prevention and treatment of infection.