Paul G Glenn

Author:

Paul J. Glenn

ISBN #:

0895550814

US Patent:

20220364996, Nov 17, 2022

Filed:

Jul 29, 2022

Appl. No.:

17/877837

Inventors:

- Guilford CT, US
Ali Kabiri - Guilford CT, US
Jason W. Sickler - Arlington MA, US
Jeremy Lackey - Foster City CA, US
Gerard Schmid - Guilford CT, US
Benjamin Cipriany - Branford CT, US
Jack Jewell - Boulder CO, US
Lawrence C. West - San Jose CA, US
Michael Ferrigno - Farmington CT, US
Paul E. Glenn - Wellesley MA, US
Anthony Bellofiore - Glastonbury CT, US

Assignee:

Quantum-Si Incorporated - Guilford CT

International Classification:

G01N 21/64
C12Q 1/6874
G01N 21/77
B01L 3/00
C12Q 1/6869

Abstract:

Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits radiation; at least one element for directing the emission radiation in a particular direction; and a light path along which the emission radiation travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the integrated device. Each sensor may detect emission radiation from a sample in a respective sample well. The instrument includes an excitation light source for exciting the sample in each sample well.

US Patent:

20220349823, Nov 3, 2022

Filed:

Jul 11, 2022

Appl. No.:

17/862297

Inventors:

- Guilford CT, US
Ali Kabiri - Guilford CT, US
Gerard Schmid - Guilford CT, US
Keith G. Fife - Palo Alto CA, US
James Beach - Austin TX, US
Jason W. Sickler - Arlington MA, US
Lawrence C. West - San Jose CA, US
Paul E. Glenn - Wellesley MA, US
Kyle Preston - Guilford CT, US
Farshid Ghasemi - Guilford CT, US
Benjamin Cipriany - Branford CT, US
Jeremy Lackey - Foster City CA, US

Assignee:

Quantum-Si Incorporated - Guilford CT

International Classification:

G01N 21/64
C12Q 1/6869
C12Q 1/6874
G01N 21/77
G01N 33/543

Abstract:

System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device may include multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes a surface having a trench region recessed from a portion of the surface and an array of sample wells, disposed in the trench region. The integrated device also includes a waveguide configured to couple excitation energy to at least one sample well in the array and positioned at a first distance from a surface of the trench region and at a second distance from the surface in a region separate from the trench region. The first distance is smaller than the second distance. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.

US Patent:

20220214279, Jul 7, 2022

Filed:

Mar 25, 2022

Appl. No.:

17/704691

Inventors:

- Guilford CT, US
Ali Kabiri - Guilford CT, US
Jason W. Sickler - Arlington MA, US
Brett J. Gyarfas - Aptos CA, US
Jeremy Lackey - Foster City CA, US
Gerard Schmid - Guilford CT, US
Jack Jewell - Boulder CO, US
Lawrence C. West - San Jose CA, US
Michael Ferrigno - Farmington CT, US
Paul E. Glenn - Wellesley MA, US
Adam Ezra Cohen - Cambridge MA, US
Anthony Bellofiore - Glastonbury CT, US

Assignee:

Quantum-Si Incorporated - Guilford CT

International Classification:

G01N 21/64
B01L 3/00
G01N 21/77
C12Q 1/6874
C12Q 1/6869

Abstract:

Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.

US Patent:

20210148821, May 20, 2021

Filed:

Jan 28, 2021

Appl. No.:

17/161425

Inventors:

- Guilford CT, US
Ali Kabiri - Guilford CT, US
Gerard Schmid - Guilford CT, US
Keith G. Fife - Palo Alto CA, US
James Beach - Austin TX, US
Jason W. Sickler - Arlington MA, US
Lawrence C. West - San Jose CA, US
Paul E. Glenn - Wellesley MA, US
Kyle Preston - Guilford CT, US
Farshid Ghasemi - Guilford CT, US
Benjamin Cipriany - Branford CT, US
Jeremy Lackey - Foster City CA, US

Assignee:

Quantum-Si Incorporated - Guilford CT

International Classification:

G01N 21/64
C12Q 1/6869
C12Q 1/6874
G01N 21/77
G01N 33/543

Abstract:

System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device may include multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes a surface having a trench region recessed from a portion of the surface and an array of sample wells, disposed in the trench region. The integrated device also includes a waveguide configured to couple excitation energy to at least one sample well in the array and positioned at a first distance from a surface of the trench region and at a second distance from the surface in a region separate from the trench region. The first distance is smaller than the second distance. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.

US Patent:

20200088643, Mar 19, 2020

Filed:

Nov 19, 2019

Appl. No.:

16/689004

Inventors:

- Guilford CT, US
Ali Kabiri - Madison CT, US
Jason W. Sickler - Arlington MA, US
Brett J. Gyarfas - Guilford CT, US
Jeremy Lackey - Guilford CT, US
Gerard Schmid - Guilford CT, US
Benjamin Cipriany - Branford CT, US
Jack Jewell - Boulder CO, US
Lawrence C. West - San Jose CA, US
Michael Ferrigno - Farmington CT, US
Paul E. Glenn - Wellesley MA, US
Adam Ezra Cohen - Cambridge MA, US
Anthony Bellofiore - Glastonbury CT, US

Assignee:

Quantum-Si Incorporated - Guilford CT

International Classification:

G01N 21/64
C12Q 1/6869
B01L 3/00
G01N 21/77
C12Q 1/6874

Abstract:

Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.

US Patent:

20190383739, Dec 19, 2019

Filed:

Jun 17, 2019

Appl. No.:

16/442861

Inventors:

- Guilford CT, US
Ali Kabiri - Madison CT, US
Jason W. Sickler - Arlington MA, US
Brett J. Gyarfas - Guilford CT, US
Jeremy Lackey - Guilford CT, US
Gerard Schmid - Guilford CT, US
Paul E. Glenn - Wellesley MA, US
Lawrence C. West - San Jose CA, US
Benjamin Cipriany - Branford CT, US
Keith G. Fife - Palo Alto CA, US

Assignee:

Quantum-Si Incorporated - Guilford CT

International Classification:

G01N 21/64
C12Q 1/6874

Abstract:

Apparatus and methods for analyzing single molecules and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.

US Patent:

20190025214, Jan 24, 2019

Filed:

Jul 24, 2018

Appl. No.:

16/043651

Inventors:

- Guilford CT, US
Benjamin Cipriany - Branford CT, US
Todd Rearick - Cheshire CT, US
Paul E. Glenn - Wellesley MA, US
Faisal R. Ahmad - Guilford CT, US
Todd Roswech - Westbrook CT, US
Brittany Lathrop - Derby CT, US
Thomas Connolly - Cheshire CT, US

Assignee:

Quantum-Si Incoroprated - Guilford CT

International Classification:

G01N 21/64
H01S 5/00
H01S 5/026
H01S 5/022
H01S 5/024

Abstract:

A hand-held bioanalytic instrument is described that can perform massively parallel sample analysis including single-molecule gene sequencing. The instrument includes a pulsed optical source that produces ultrashort excitation pulses and a compact beam-steering assembly. The beam-steering assembly provides automated alignment of excitation pulses to an interchangeable bio-optoelectronic chip that contains tens of thousands of reaction chambers or more. The optical source, beam-steering assembly, bio-optoelectronic chip, and coupling optics register to an alignment structure in the instrument that can form at least one wall of an enclosure and dissipate heat.

US Patent:

20180328850, Nov 15, 2018

Filed:

Jul 5, 2018

Appl. No.:

16/028159

Inventors:

- Guilford CT, US
Ali Kabiri - Madison CT, US
Jason W. Sickler - Madison CT, US
Brett J. Gyarfas - Guilford CT, US
Jeremy Lackey - Guilford CT, US
Gerard Schmid - Guilford CT, US
Benjamin Cipriany - Branford CT, US
Jack Jewell - Boulder CO, US
Lawrence C. West - San Jose CA, US
Michael Ferrigno - Farmington CT, US
Paul E. Glenn - Wellesley MA, US
Anthony Bellofiore - Glastonbury CT, US

Assignee:

Quantum-Si Incorporated - Guilford CT

International Classification:

G01N 21/64
B01L 3/00
C12Q 1/6869
C12Q 1/6874
G01N 21/77

Abstract:

Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits radiation; at least one element for directing the emission radiation in a particular direction; and a light path along which the emission radiation travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the integrated device. Each sensor may detect emission radiation from a sample in a respective sample well. The instrument includes an excitation light source for exciting the sample in each sample well.