Paul John Donders

US Patent:

20130169957, Jul 4, 2013

Filed:

Nov 13, 2012

Appl. No.:

13/675687

Inventors:

Grace H. Chen - Los Gatos CA, US
Kai Cao - Fremont CA, US
Jamie M. Sullivan - Sunnyvale CA, US
Paul J. Donders - Fremont CA, US
Derek C. Mackay - Menlo Park CA, US

Assignee:

KLA-Tencor Corporation - Milpitas CA

International Classification:

G01N 21/88

US Classification:

3562371

Abstract:

Disclosed are apparatus and methods for inspecting or measuring a specimen. An incident beam is directed across a plurality of consecutive scan portions of a specimen so that an output beam profile from each scan portion is consecutively collected by a photomultiplier tube (PMT), and the scan portions include at least one or more first scan portions and a next scan portion that is scanned after the one or more first scan portions. After or while the incident beam is directed to the one or more first scan portions of the specimen, an output signal for each first scan portion is obtained based on the output beam profile that is collected by the PMT for each first scan portion. An expected output beam profile for the next scan portion is determined based on the output signal that is obtained for each one or more first scan portions. As the incident beam is directed towards the next scan portion, a gain input to the PMT for the next scan portion is set based on the expected output beam profile so that the gain for such next scan portion results in a measured signal at the PMT that is within a predefined specification of the PMT or other hardware components that receive a measured signal from the PMT.

US Patent:

20100254590, Oct 7, 2010

Filed:

Jun 17, 2010

Appl. No.:

12/817422

Inventors:

PETER RAMM - ST. CATHARINES, CA
YURIY ALEXANDROV - CARDIFF, GB
JURICH CYBUCH - ST. CATHARINES, CA
PAUL DONDERS - FREMONT CA, US
CARLOS ZARATE - CABA, AR
BOHDAN J. SOLTYS - OAKVILLE, CA

Assignee:

GE HEALTHCARE NIAGARA INC. - MISSISSAUGA

International Classification:

G06T 7/00

US Classification:

382133

Abstract:

A system for performing automated cell screening in drug discovery, includes an automated microscope, a fast autofocus device, and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known to methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.

US Patent:

20150136948, May 21, 2015

Filed:

Oct 17, 2014

Appl. No.:

14/517375

Inventors:

- Milpitas CA, US
Paul Donders - Fremont CA, US
Kai Cao - Fremont CA, US
Jeongsik Lim - Sunnyvale CA, US

International Classification:

H01J 40/12
H01J 40/16

US Classification:

250207

Abstract:

A bias-variant photomultiplier tube (PMT) includes a photocathode that when operating absorbs photons and emit photoelectrons responsive to the absorbed photons. The bias-variant PMTO also includes a plurality of dynodes that receive the photoelectrons emitted by the photocathode. The plurality of dynodes include a first pair of dynodes having a first bias difference and at least a second pair of dynodes having a second bias. The second bias difference is greater than the first bias difference. The bias-variant PMTO also includes an anode to receive photoelectrons directed from the plurality of dynodes.