Patrycja J Lech

US Patent:

20140024100, Jan 23, 2014

Filed:

Jul 19, 2013

Appl. No.:

13/946430

Inventors:

Patrycja Lech - Rochester MN, US

International Classification:

C07K 14/005
C12N 7/00

US Classification:

4352351, 530350, 536 2372

Abstract:

This document provides methods and materials for making and using measles viruses having a reduced susceptibility to antibody neutralization (e.g., antibody neutralization by monoclonal anti-measles virus antibodies and/or serum from measles virus vaccinees). For example, H polypeptides having a reduced ability of being recognized by anti-measles virus antibodies that were generated against a wild-type measles virus or a pre-existing measles virus vaccine such as MV-Edm as compared to a wild-type measles virus H polypeptide or the H polypeptide of MV-Edm are provided.

US Patent:

20180103620, Apr 19, 2018

Filed:

Apr 15, 2016

Appl. No.:

15/566827

Inventors:

- Rochester MN, US
Stephen James Russell - Rochester MN, US
Patrycja Lech - Oronoco MN, US

Assignee:

Mayo Foundation for Medical Education and Research - Rochester MN

International Classification:

A01K 67/027
A61K 51/02

Abstract:

This document provides methods and materials for using live transgenic non-human animals (e.g., non-human mammals) to perform radiotracer imaging to monitor pathological processes, disease progression, or therapeutic responses in vivo over time. For example, methods and materials for using live transgenic non-human animals (e.g., non-human mammals) having somatic and germline cells that include nucleic acid (e.g., a transgene) having a promoter sequence operably linked to a nucleic acid sequence encoding a NIS polypeptide to perform radiotracer imaging to monitor pathological processes, disease progression, or therapeutic responses in vivo over time are provided.

US Patent:

20160046680, Feb 18, 2016

Filed:

Mar 13, 2014

Appl. No.:

14/777348

Inventors:

- Rochester MN, US
Kah-Whye Peng - Rochester MN, US
Patrycja Lech - Rochester MN, US

International Classification:

C07K 14/47
A61K 51/00

Abstract:

This document provides methods and materials involved in radiotracer imaging using NIS polypeptides. For example, methods and materials for performing imaging techniques that increase the detection sensitivity and resolution of radiotracers localized by NIS reporter gene expression and/or decrease background signals that can be attributed to endogenously expressed NIS polypeptides are provided.

US Patent:

20140271456, Sep 18, 2014

Filed:

Mar 13, 2014

Appl. No.:

14/209369

Inventors:

- Rochester MN, US
Kah-Whye Peng - Rochester MN, US
Patrycja Lech - Rochester MN, US

Assignee:

Mayo Foundation for Medical Education and Research - Rochester MN

International Classification:

A61K 51/02

US Classification:

424 111

Abstract:

This document provides methods and materials involved in radiotracer imaging using NIS polypeptides. For example, methods and materials for performing imaging techniques that increase the detection sensitivity and resolution of radiotracers localized by NIS reporter gene expression and/or decrease background signals that can be attributed to endogenously expressed NIS polypeptides are provided.