Hemant Thatte - Medfield MA, US Patrick Treanor - Dedham MA, US Shukri F. Khuri - Needham MA, US Randa Khuri, legal representative - Needham MA, US Laki Rousou - New York NY, US
Assignee:
President and Fellows of Harvard College - Cambridge MA The United States of America as Represented by the Department of Veterans Affairs - Washington DC
International Classification:
A01N 1/00
US Classification:
435 11, 435 12
Abstract:
Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions.
Shukri Khuri - Westwood MA, US Patrick Treanor - Dedham MA, US
Assignee:
E-Monitors, Inc. - Tewksbury MA
International Classification:
A61B005/05
US Classification:
600/345000
Abstract:
The invention relates to the use of pH measurements of tissue as a system for controlling diagnostic and/or surgical procedures. The invention also relates to an apparatus used to perform tissue pH measurements. Real time tissue pH measurements can be used as a method to determine ischemic segments of the tissue and provide the user with courses of conduct during and after a surgical procedure. When ischemia is found to be present in a tissue, a user can effect an optimal delivery of preservation fluids to the site of interest and/or effect a change in the conduct of the procedure to raise the pH of the site. A preferred embodiment includes a method of detecting acidosis in tissue comprising the steps of contacting the tissue of a patient with a first pH electrode disposed in an anterior wall of the left ventricle, and further contacting the tissue of the patient with a second pH electrode disposed in a posterior wall of the left ventricle.
Shukri Khuri - Westwood MA, US Patrick Treanor - Dedham MA, US
Assignee:
E-Monitors, Inc. - Tewksbury MA
International Classification:
A61B005/05
US Classification:
600/345000, 604/065000, 604/066000, 604/067000
Abstract:
While ischemia or tissue acidosis, in cardiac tissue has been measured, systems and methods to prevent and/or reverse tissue, and in particular, cardiac acidosis were unknown. Surgeons did not know how to reverse tissue acidosis once discovered. The present invention relates to systems and/or methods of using tissue pH measurements to diagnose ischemia and to gauge the conduct of an operation, based on these pH measurements, so as to prevent and/or reverse tissue ischemia/acidosis. The current invention provides methods by which tissue acidosis can be corrected once discovered.
Hemant Thatte - Medfield MA, US Patrick Treanor - Dedham MA, US Shukri F. Khuri - Needham MA, US Randa Khuri - Needham MA, US Laki Rousou - New York NY, US
Assignee:
President and Fellows of Harvard College - Cambridge MA General Counsel-PSG IV (024) - Washington DC
International Classification:
A01N 1/02
US Classification:
435 12, 435 11, 435374
Abstract:
Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions.
Hemant Thatte - Medfield MA, US Patrick Treanor - Dedham MA, US Shukri F. Khuri - Needham MA, US Randa Khuri - Needham MA, US Laki Rousou - New York NY, US
Assignee:
United States Government as Represented by the Department of Veterans Affairs - Washington DC President and Fellows of Harvard College - Cambridge MA
International Classification:
A01N 1/02 C12N 5/071
US Classification:
435 12, 435 11, 435374
Abstract:
Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions.
Shukri F. Khuri - Westwood MA Patrick Treanor - Dedham MA
Assignee:
E-Monitors, Inc. - Tewksbury MA
International Classification:
A61B 500
US Classification:
600345, 604 65, 604 66, 604 67, 126897
Abstract:
The invention relates to the use of pH measurements of tissue as a system for controlling diagnostic and/or surgical procedures. The invention also relates to an apparatus used to perform tissue pH measurements. Tissue pH measurements can be used as a method to determine ischemic segments of the tissue and provide the user with courses of conduct during and after a surgical procedure. When ischemia is found to be present in a tissue, a user can effect an optimal delivery of preservation fluids to the site of interest and/or effect a change in the conduct of the procedure to raise the pH of the site.
Name / Title
Company / Classification
Phones & Addresses
Patrick R. Treanor President
BOSTON PERFUSION AND CELL SAVING, INC
22 Curv St, Dedham, MA 02026 122 Curv St, Dedham, MA 02026
Patrick R. Treanor Manager
BOSTON METABOLIC DIAGNOSTICS, LLC
593 High St, Dedham, MA 02026
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