Patrick J O'Hara

US Patent:

20020137159, Sep 26, 2002

Filed:

Aug 22, 2001

Appl. No.:

09/934814

Inventors:

Si Lok - Seattle WA, US
James Holloway - Seattle WA, US
Patrick O'Hara - Seattle WA, US

International Classification:

C12N009/00
C07H021/04
C12P021/02
C12N005/06

US Classification:

435/183000, 435/069100, 435/325000, 435/320100, 536/023200

Abstract:

Human phermones may be used to alleviate anxiety, promote beneficial moods, and to alter hypothalamic functions, such as satiety, energy balance, and reproductive biology. The present invention provides a new group of human pheromone polypeptides, collectively designated “ZHMUP-1.”

US Patent:

20030100046, May 29, 2003

Filed:

Mar 12, 1997

Appl. No.:

08/815773

Inventors:

JAMES W. BAUMGARTNER - SEATTLE WA, US
THERESA M. FARRAH - SEATTLE WA, US
DONALD C. FOSTER - SEATTLE WA, US
FRANK J. GRANT - SEATTLE WA, US
PATRICK J. O'HARA - SEATTLE WA, US

International Classification:

C07K014/72
C12P021/02
C12N005/06
C07H021/04

US Classification:

435/069100, 536/023500, 530/350000, 435/320100, 435/325000

Abstract:

Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in testis cells. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of testis cells, and may also be used in the development of male-specific contraceptives and infertility treatments.

US Patent:

20030100047, May 29, 2003

Filed:

Jun 4, 1998

Appl. No.:

09/090867

Inventors:

JAMES W. BAUMGARTNER - THOUSAND OAKS CA, US
THERESA M. FARRAH - SEATTLE WA, US
DONALD C. FOSTER - SEATTLE WA, US
FRANK J. GRANT - SEATTLE WA, US
PATRICK J. O'HARA - SEATTLE WA, US

International Classification:

C07K014/72
C12P021/02
C12N005/06
C07H021/04

US Classification:

435/069100, 435/320100, 435/325000, 536/023500, 530/350000

Abstract:

Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in testis cells. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of testis cells, and may also be used in the development of male-specific contraceptives and infertility treatments.

US Patent:

20030166070, Sep 4, 2003

Filed:

May 9, 2002

Appl. No.:

10/142465

Inventors:

Si Lok - Seattle WA, US
James Holloway - Seattle WA, US
Patrick O'Hara - Seattle WA, US

International Classification:

C12P021/02
C12N005/06
C07K014/435
C07H021/04

US Classification:

435/069100, 435/320100, 435/325000, 530/399000, 536/023200

Abstract:

Human phermones may be used to alleviate anxiety, promote beneficial moods, and to alter hypothalamic functions, such as satiety, energy balance, and reproductive biology. The present invention provides a new group of human pheromone polypeptides, collectively designated “ZHMUP-1.”

US Patent:

20050003424, Jan 6, 2005

Filed:

Jul 12, 2004

Appl. No.:

10/887865

Inventors:

James Baumgartner - Thousand Oaks CA, US
Theresa Farrah - Cairo, EG
Donald Foster - Lake Forest Park WA, US
Frank Grant - Seattle WA, US
Patrick O'Hara - Seattle WA, US

International Classification:

C12Q001/68
C07H021/04
C07K014/705

US Classification:

435006000, 435069100, 435320100, 435325000, 530350000, 536023500

Abstract:

Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in testis cells. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of testis cells, and may also be used in the development of male-specific contraceptives and infertility treatments.

US Patent:

20050020824, Jan 27, 2005

Filed:

Jul 12, 2004

Appl. No.:

10/887863

Inventors:

James Baumgartner - Thousands Oaks CA, US
Theresa Farrah - Cairo, EG
Donald Foster - Lake Forest Park WA, US
Frank Grant - Seattle WA, US
Patrick O'Hara - Seattle WA, US

International Classification:

C07H021/04
C07K014/705

US Classification:

536023500, 530350000, 435069100, 435320100, 435325000

Abstract:

Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in testis cells. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of testis cells, and may also be used in the development of male-specific contraceptives and infertility treatments.

US Patent:

20060110800, May 25, 2006

Filed:

Jan 13, 2006

Appl. No.:

11/331993

Inventors:

James Baumgartner - Thousand Oaks CA, US
Theresa Farrah - Cairo, EG
Donald Foster - Lake Forest Park WA, US
Frank Grant - Seattle WA, US
Patrick O'Hara - Seattle WA, US

International Classification:

C07K 14/72
C07K 16/28
C07H 21/04
C12P 21/06

US Classification:

435069100, 536023500, 530350000, 435320100, 435325000, 530388220

Abstract:

Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in testis cells. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of testis cells, and may also be used in the development of male-specific contraceptives and infertility treatments.

US Patent:

52003400, Apr 6, 1993

Filed:

May 22, 1987

Appl. No.:

7/053412

Inventors:

Donald C. Foster - Seattle WA
Eileen R. Mulvihill - Seattle WA
Patrick J. O'Hara - Seattle WA
Kurt Pingel - Farum, DK
Shinji Yoshitake - Ibaraki, JP

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

C12N 961
C12N 1500
C12N 1558
C12N 1535

US Classification:

424 9464

Abstract:

Zymogens of proteins having fibrinolytic activity are disclosed. The proteins are cleavable by thrombin, the cleavage resulting in the stimulation of fibrinolytic activity. Suitable proteins which may be modified in accordance with the present invention include tissue plasminogen activator, urokinase, and plasminogen variants. The modified molecules are substantially clot-specific, in view of the large amounts of thrombin associated with clots in vivo.