Patricia Ann Rao

US Patent:

20020147312, Oct 10, 2002

Filed:

Jan 30, 2002

Appl. No.:

10/060714

Inventors:

Theresa O'Keefe - Waltham MA, US
Patricia Rao - Acton MA, US

International Classification:

C07K016/28

US Classification:

530/387300, 530/388150

Abstract:

Methods of providing hybrid antibodies having improved assembly characteristics are disclosed. Accordingly, the present invention provides hybrid antibodies, antigen binding fragments thereof, which include a chimeric immunoglobulin heavy chain and a humanized or CDR-grafted immunoglobulin light chain, pharmaceutical compositions thereof, as well as nucleic acids encoding the aforesaid antibodies, host cells and vectors containing such nucleic acids. Therapeutic and diagnostic uses of such hybrid antibodies molecules thereof are also disclosed.

US Patent:

20200140530, May 7, 2020

Filed:

Oct 9, 2019

Appl. No.:

16/597593

Inventors:

- Rahway NJ, US
Barbara S. FOX - Wayland MA, US
Stavros KOPSIAFTIS - West Roxbury MA, US
Yacob GOMEZ LLORENTE - New York NY, US
Renee MOORE - Medway MA, US
Patricia RAO - Acton MA, US
Giovanna SCAPIN - New York NY, US
Kenneth J. SIMON - Milton MA, US
Haihong ZHOU - Westfield NJ, US

International Classification:

C07K 16/18
G01N 33/574
G01N 33/68
A61P 35/00
A61P 35/04

Abstract:

Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGFβ1 on cells but not to LAP-TGFβ1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.