Patricia E Lopez

US Patent:

20220194955, Jun 23, 2022

Filed:

Dec 15, 2021

Appl. No.:

17/552016

Inventors:

- Thousand Oaks CA, US
Matthew Paul BOURBEAU - Woodland Hills CA, US
John R. BUTLER - Thousand Oaks CA, US
Sanne Ormholt Schroder GLAD - Ballerup, DK
Brian Alan LANMAN - Woodland Hills CA, US
Patricia LOPEZ - Woodland Hills CA, US
Francesco MANONI - Newbury Park CA, US
Liping H. PETTUS - Thousand Oaks CA, US
Ian SARVARY - Greve, DK
Nuria A. TAMAYO - Newbury Park CA, US
Mikkel VESTERGAARD - Greve, DK
Nicholas Anthony WEIRES - Thousand Oaks CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07D 491/06
C07D 491/16
C07D 471/06
C07D 471/16
A61P 35/00

Abstract:

Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders. Compounds of Formula I have the following structure:

US Patent:

20220175782, Jun 9, 2022

Filed:

Jan 19, 2022

Appl. No.:

17/579359

Inventors:

- Thousand Oaks CA, US
Brian Alan LANMAN - Woodland Hills CA, US
Jian CHEN - San Diego CA, US
Anthony B. REED - Newbury Park CA, US
Victor J. CEE - Thousand Oaks CA, US
Longbin LIU - Thousand Oaks CA, US
Patricia LOPEZ - Woodland Hills CA, US
Ryan Paul WURZ - Newbury Park CA, US
Thomas T. NGUYEN - Newbury Park CA, US
Shon BOOKER - Sherman Oaks CA, US
Jennifer Rebecca ALLEN - Newbury Park CA, US
Margaret CHU-MOYER - Brookline MA, US
Albert AMEGADZIE - Westlake Village CA, US
Ning CHEN - Thousand Oaks CA, US
Clifford GOODMAN - Calabasas CA, US
Jonathan D. LOW - Northridge CA, US
Vu Van MA - Oak Park CA, US
Ana Elena MINATTI - Santa Monica CA, US
Nobuko NISHIMURA - West Hills CA, US
Alexander J. PICKRELL - Westlake Village CA, US
Hui-Ling WANG - Thousand Oaks CA, US
Youngsook SHIN - Seoul, KR
Aaron C. SIEGMUND - Ventura CA, US
Kevin C. YANG - San Gabriel CA, US
Nuria A. TAMAYO - Newbury Park CA, US
Mary WALTON - Camarillo CA, US
Qiufen XUE - Thousand Oaks CA, US

International Classification:

A61K 31/519
A61K 31/551
A61K 39/395
A61P 35/00

Abstract:

Provided herein are KRAS G12C inhibitors, such ascomposition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

US Patent:

20200369662, Nov 26, 2020

Filed:

May 20, 2020

Appl. No.:

16/878824

Inventors:

- Thousand Oaks CA, US
Patricia LOPEZ - Woodland Hills CA, US
Prashant AGARWAL - Chelsea MA, US
Albert AMEGADZIE - Moorpark CA, US
Stephanie AZALI - Woodland Hills CA, US
Roman SHIMANOVICH - Brighton MA, US
Ron C. KELLY - Westlake Village CA, US
Darren Leonard REID - Belmont MA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07D 471/04

Abstract:

The present disclosure provides crystalline and amorphous forms of 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(2-propanyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(2-propenoyl)-1-piperazinyl)pyrido[2,3-d]pyrimidin-2(1H)-one, including several anhydrous, hydrate and solvate forms, and solid state forms thereof, pharmaceutical compositions, and methods of treating a disease mediated by KRAS G12C inhibition.

US Patent:

20190374542, Dec 12, 2019

Filed:

Jun 11, 2019

Appl. No.:

16/438349

Inventors:

- Thousand Oaks CA, US
Brian Alan LANMAN - Woodland Hills CA, US
Jian CHEN - Camarillo CA, US
Anthony B. REED - Newbury Park CA, US
Victor J. CEE - Thousand Oaks CA, US
Longbin LIU - Thousand Oaks CA, US
Patricia LOPEZ - Woodland Hills CA, US
Ryan Paul WURZ - Newbury Park CA, US
Thomas T. NGUYEN - Newbury Park CA, US
Shon Booker - Sherman Oaks CA, US
Jennifer Rebecca ALLEN - Newbury Park CA, US
Margaret CHU-MOYER - Brookline MA, US
Albert AMEGADZIE - Moorpark CA, US
Ning CHEN - Thousand Oaks CA, US
Clifford GOODMAN - Thousand Oaks CA, US
Jonathan D. LOW - Reseda CA, US
Vu Van MA - Oak Park CA, US
Ana Elena MINATTI - Los Angeles CA, US
Nobuko NISHIMURA - West Hills CA, US
Alexander J. PICKRELL - Westlake Village CA, US
Hui-Ling WANG - Thousand Oaks CA, US
Youngsook SHIN - Thousand Oaks CA, US
Aaron C. SIEGMUND - Ventura CA, US
Kevin C. YANG - San Gabriel CA, US
Nuria A. TAMAYO - Newbury Park CA, US
Mary WALTON - Burlingame CA, US
Qiufen XUE - Thousand Oaks CA, US

International Classification:

A61K 31/519
A61P 35/00
A61K 39/395
A61K 31/551

Abstract:

Provided herein are KRAS G12C inhibitors, such ascomposition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

US Patent:

20160280695, Sep 29, 2016

Filed:

Nov 4, 2015

Appl. No.:

14/932787

Inventors:

- Thousand Oaks CA, US
Jonathan D. LOW - Reseda CA, US
Jennifer R. ALLEN - Newbury Park CA, US
Albert AMEGADZIE - Moorpark CA, US
James BROWN - Moorpark CA, US
Michael J. FROHN - Thousand Oaks CA, US
Angel GUZMAN-PEREZ - Belmont MA, US
Paul E. HARRINGTON - Camarillo CA, US
Patricia LOPEZ - Woodland Hills CA, US
Vu Van MA - Oak Park CA, US
Nobuko NISHIMURA - West Hills CA, US
Wenyuan QIAN - Newbury Park CA, US
Shannon RUMFELT - Camarillo CA, US
Robert M. RZASA - Ventura CA, US
Kelvin SHAM - Thousand Oaks CA, US
Adrian L. SMITH - Simi Valley CA, US
Ryan WHITE - Somerville MA, US
Qiufen XUE - Newbury Park CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07D 413/12

Abstract:

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I:wherein variables A, A, A, A, each of R, R, R, R, Rand Rof Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

US Patent:

20150252011, Sep 10, 2015

Filed:

Apr 21, 2015

Appl. No.:

14/691715

Inventors:

- Thousand Oaks CA, US
Jonathan D. LOW - Reseda CA, US
Jennifer R. ALLEN - Newbury Park CA, US
Albert AMEGADZIE - Moorpark CA, US
James BROWN - Moorpark CA, US
Michael J. FROHN - Thousand Oaks CA, US
Angel GUZMAN-PEREZ - Belmont MA, US
Paul E. HARRINGTON - Camarillo CA, US
Patricia LOPEZ - Woodland Hills CA, US
Vu Van MA - Oak Park CA, US
Nobuko NISHIMURA - West Hills CA, US
Wenyuan QIAN - Newbury Park CA, US
Shannon RUMFELT - Camarillo CA, US
Robert M. RZASA - Ventura CA, US
Kelvin SHAM - Thousand Oaks CA, US
Adrian L. SMITH - Simi Valley CA, US
Ryan WHITE - Somerville MA, US
Qiufen XUE - Newbury Park CA, US

International Classification:

C07D 265/12
C07D 413/04
C07D 413/10
C07D 413/14
C07D 417/12
C07D 417/14
C07D 413/12
C07D 471/04

Abstract:

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I:wherein variables A, A, A, A, each of R, R, R, R, Rand Rof Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

US Patent:

20140275058, Sep 18, 2014

Filed:

Mar 6, 2014

Appl. No.:

14/199844

Inventors:

- Thousand Oaks CA, US
Jonathan D. LOW - Tarzana CA, US
Jennifer R. ALLEN - Newbury Park CA, US
Albert AMEGADZIE - Moorpark CA, US
James BROWN - Moorpark CA, US
Michael J. FROHN - Thousand Oaks CA, US
Angel GUZMAN-PEREZ - Belmont MA, US
Paul E. HARRINGTON - Camarillo CA, US
Patricia LOPEZ - Woodland Hills CA, US
Vu Van MA - Oak Park CA, US
Nobuko NISHIMURA - West Hills CA, US
Wenyuan QIAN - Newbury Park CA, US
Shannon RUMFELT - Camarillo CA, US
Robert M. RZASA - Ventura CA, US
Kelvin SHAM - Thousand Oaks CA, US
Adrian L. SMITH - Simi Valley CA, US
Ryan WHITE - Somerville MA, US
Qiufen XUE - Newbury Park CA, US

International Classification:

C07D 471/04
C07D 265/12
C07D 417/12
C07D 417/14
C07D 413/12
C07D 413/14

US Classification:

5142305, 544 90

Abstract:

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I:wherein variables A, A, A, A, each of R, R, R, R, Rand Rof Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

US Patent:

20140249104, Sep 4, 2014

Filed:

Feb 27, 2014

Appl. No.:

14/192710

Inventors:

- Thousand Oaks CA, US
Jonathan D. LOW - Tarzana CA, US
Jennifer R. ALLEN - Newbury Park CA, US
Jian CHEN - Camarillo CA, US
Ning CHEN - Thousand Oaks CA, US
Yuan CHENG - Newbury Park CA, US
Ted JUDD - Granada Hills CA, US
Qingyian LIU - Camarillo CA, US
Patricia LOPEZ - Woodland Hills CA, US
Wenyuan QIAN - Newbury Park CA, US
Shannon RUMFELT - Camarillo CA, US
Robert M. RZASA - Ventura CA, US
Nuria A. TAMAYO - Newbury Park CA, US
Qiufen XUE - Newbury Park CA, US
Bryant YANG - Agoura Hills CA, US
Wenge ZHONG - Thousand Oaks CA, US

International Classification:

C07D 413/14
C07F 7/08
C07D 513/04
C07D 413/12
C07D 471/04

US Classification:

514 63, 544 96, 5142288, 544 69

Abstract:

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I:wherein variables A, A, A, A, each of Rand R, Rand Rof Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.