Oswaldo A Lozoya

US Patent:

20110274666, Nov 10, 2011

Filed:

May 6, 2011

Appl. No.:

13/102939

Inventors:

Rachael TURNER - Carrboro NC, US
David GERBER - Chapel Hill NC, US
Oswaldo LOZOYA - Cary NC, US
Lola M. REID - Chapel Hill NC, US

International Classification:

A61K 35/12
A61M 37/00
A61M 5/31
C12N 5/02

US Classification:

424 937, 435374, 435325, 604522, 604506

Abstract:

A method of repairing diseased or dysfunctional organs or of establishing a model system of a disease state is provided. For repairing diseased organs, the method involves engraftment of cells from healthy tissue of the diseased or dysfunctional organ admixed with gel-forming biomaterials and nutrient medium, signaling molecules and extracellular matrix components that can be made insoluble rapidly upon transplantation to form a graft. In this way, the graft mimics the complexity of the native microenvironment with a minimum number of components that allow transplantation of cells to successfully engraft, expand and then rebuild part or the entirety of the diseased or dysfunctional organ. In the case of using grafting methods for establishing a disease model, diseased cells may be transplanted in the biomaterials and into experimental hosts.